Multicentric reticulohistiocytosis with prominent skin lesions and arthritis: A case report.

Background: Multicentric reticulohistiocytosis (MRH) is a rare non-Langerhans histiocytosis of unknown etiology characterized by papulonodular skin lesions and progressive, erosive arthritis. To date, there have been approximately 300 cases of MRH reported worldwide. The majority of patients are Caucasian from western countries, and Asian patients are rare.

[Characteristics and Risks of Heavy Metals Content in Surface Sediment of Tidal Flat Areas in Eastern China].

To understand the heavy metals content such as As, Cd, Cr, Cu, Hg, Pb, and Zn, as well as their distribution features in surface sediments of tidal flat areas of Eastern China, mathematical statistics, correlation analysis, factor analysis and other statistical methods are used. This study collected 1906 surface sediment samples of As, Cd, Cr, Cu, Hg, Pb, Zn were collected as part of a systematic research effort. These results show that the coastal tidal flats zone of Eastern China contains surface sediment samples with heavy metal concentrations (As, Cd, Cr, Cu, Hg, Pb, and Zn) with is not high but has increased due to anthropogenic sources.

[Effect of Non-dissolved Quinone on Perchlorate Reduction by Strain GWF].

The perchlorate reduction lag phase of the strain GWF (KM062029) was shortened by using non-dissolved quinone. nthraquinone, 1-chloroanthraquinone, 1,5-dichloroanthraquinone, 1,8-dichloroanthraquinone and 1,4,5,8-tetrachloranthtaquinone were the five non-dissolved quinones in this study. The results showed that the accelerating order was 1,5-dichloroanthraquinone > 1,4, 5,8-tetrachloroanthtaquinone > 1,8-dichloroanthraquinone > Anthraquinone > 1-chloroanthraquinone.

Role of Tim-3 in hepatitis B virus infection: An overview.

Hepatitis B virus (HBV) infection has received increasing public attention. HBV is the prototypical member of hepadnaviruses, which naturally infect only humans and great apes and induce the acute and persistent chronic infection of hepatocytes. A large body of evidence has demonstrated that dysfunction of the host anti-viral immune response is responsible for persistent HBV replication, unresolved inflammation and disease progression.

Tim-4 Inhibits NO Generation by Murine Macrophages.

Objective: T cell immunoglobulin- and mucin-domain-containing molecule-4 (Tim-4) receives much attention as a potentially negative regulator of immune responses. However, its modulation on macrophages has not been fully elucidated so far. This study aimed to identify the role of Tim-4 in nitric oxide (NO) modulation.

Therapeutic effects of 5-fluorouracil sustained-release particles in 81 malignant pericardial effusion patients.

This study aimed to investigate the clinical application value of the 5-fluorouracil (5-FU) sustained-release particles implanted along the cardiac tangent direction into malignant pericardial effusion (MPCE). A total of 81 MPCE patients underwent pericardiocentesis, and were implanted with 5-FU sustained-release particles into the pericardial cavity under ultrasound guidance. The puncturing path was along the cardiac tangent direction.

Induction of apoptosis by IGFBP3 overexpression in hepatocellular carcinoma cells.

Background: The insulin-like growth factor (IGF) system comprises a group of proteins that play key roles in regulating cell growth, differentiation, and apoptosis in a variety of cellular systems. The aim of this study was to investigate the role of insulin-like growth factor binding protein 3 (IGFBP3) in hepatocellular carcinoma.

Materials And Methods: Expression of IGF2, IGFBP3, and PTEN was analyzed by qRT-PCR.

[Study on germination rate of zoysia (Zoysia japonica Steud.) seeds using near infrared reflectance spectroscopy].

With 37 zoysia seed samples with different germination rates ranging from 58.5% to 92%, harvested in different years from 2009 to 2011 and from different locations of China, a model for determining germination rate of zoysia seeds was tried to be built by near infrared reflectance spectroscopy with quantitative partial least squares (QPLS). All the seeds samples were divided into two groups: calibration set (including 28 samples) and validation set (including 9 samples).

Aberrant expression of chemokine receptor CCR4 in human gastric cancer contributes to tumor-induced immunosuppression.

The chemokine receptor CCR4 is preferentially expressed on certain immune cells and some hematological tumor cells, which play pivotal roles in suppression of host immune response. However, the reasons for the upmodulation of CCR4 and its immune functions in solid tumors remain unclear. Herein, we aimed to determine the expression profiles of CCR4 in gastric cancer cells and its role in regulating antitumor immunity.

[Combination of canales sacralis drop with acupotomy dissolution in treatment of discogenic lumbocrural pain].

Objective: To evaluate the combination of drop in canales sacralis with acupotomy dissolution in the treatment of lumbocrural pain caused by slipped discs.

Methods: One hundred and thirty-nine patients with lumbocrural pain caused by slipped discs were randomly divided into 3 groups: cases in Group A were treated by the drop in canales sacralis, in Group B by acupotomy dissolution and in Group C by the combination of canales sacralis drop with acupotomy dissolution. MacNab score and VAS score were assayed before treatment and 1 week, 3 and 6 months after treatment.

Blockade of Tim-3 pathway ameliorates interferon-gamma production from hepatic CD8+ T cells in a mouse model of hepatitis B virus infection.

T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However, whether Tim-3 is involved in hepatitis B virus (HBV) infection remains unknown. Here, we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection.

Blockade of TRAIL pathway ameliorates HBV-induced hepatocyte apoptosis in an acute hepatitis model.

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) may play important roles during hepatitis B virus (HBV) infection. In this study, we used a recombinant human soluble death receptor 5 (sDR5) to explore its effect in a mouse model of HBV-induced acute hepatitis. By measuring blood transaminase activity and hepatocyte apoptosis, we found that sDR5 could alleviate liver damage by blocking TRAIL-induced apoptosis of HBV-transfected hepatocytes.

A novel HBV antisense RNA gene delivery system targeting hepatocellular carcinoma.

Aim: To construct a novel HBV antisense RNA delivery system targeting hapatocellular carcinoma and study its inhibitory effect in vitro and in vivo.

Methods: GE7,a 16-peptide specific to EGFR, and HA20,a homologue of N-terminus of haemagglutinin of influenza viral envelope protein, were synthesized and conjugated with polylysin. The above conjugates were organized into the pEBAF-as-preS2, a hepatocarcinoma specific HBV antisense expression vector, to construct a novel HBV antisense RNA delivery system, named AFP-enhancing 4-element complex.