Effects of Transdermal 17β-Estradiol + Norethisterone Acetate on Cardiovascular Disease Risk Factors in Postmenopausal Women: A Meta-analysis of Data From Randomized, Controlled Trials.

Purpose: To date, no study has demonstrated the role of transdermal 17β-estradiol + norethisterone acetate on all of the risk factors for cardiovascular disease in postmenopausal women. To overcome this knowledge gap, a systematic review and meta-analysis were conducted to determine the effects of this combination treatment on BMI, body weight, waist/hip ratio, fibrinogen, factor VII, lipoprotein(a), fasting blood sugar, insulin, HbA, TG, LDL-C, HDL-C, and TC in postmenopausal women.

Methods: PubMed/Medline, SCOPUS, Web of Science, Embase, and Google Scholar were searched for relevant articles published between the inception of each database and April 6, 2023.

Chronic nicotine treatment enhances vascular smooth muscle relaxation in rats.

Aim: To investigate the effect of chronic nicotine treatment on vascular function and to identify the underlying mechanisms.

Methods: Adult rats were treated with nicotine (3 mg·kg(-1)·d(-1), sc) for 6 weeks. After the rats were sacrificed, aortic rings were prepared for detecting vascular reactivity, and thoracic aorta and periaortic fat samples were collected for histological and molecular biology studies.

[Study of screening nephroprotective bioactive substances based on triple-color fluorescence probes in Carthami flos].

In this study, an approach based on triple-color fluorescence probes was developed for screening potential nephro-protective bioactive substances. Three fluorescent probes (i. e.

Vascular smooth muscle cell apoptosis is an early trigger for hypothyroid atherosclerosis.

Aims: Endothelial dysfunction is an initial and vascular smooth muscle cell (VSMC) apoptosis, a later step of atherosclerosis. Hypothyroidism accelerates atherosclerosis. However, the early events responsible for this pro-atherosclerotic effect are unclear.

[Study on rapid screening and identifying hepatotoxic compounds in toosendan fructus].

Fluorescein diacetate-labeled HepG2 cells model and flouresence automatic microscopy screening assay were used for fast screening 23 components from Toosendan Fructus, in which 5 components showed significant toxicity on HepG2 cells. The 10 compounds in the 2 components were tentatively identified with LC-MS(n), and 3 of them (meliasenin B, trichilinin D and 1-O-tigloy-1-O-debenzoylohchinal) were prepared and identified. Further experiments showed that the 3 compounds displayed dose-dependent toxicity on HepG2 cells, suggesting that these compounds in Toosendan Fructus may cause hepatotoxicity.

[Effects of three different treatments on atherosclerosis and adipose in rats].

Objective: To explore the effects of three different treatments, including probucol plus aspirin (PS), lovastatin plus aspirin (AS) and probucol, lovastatin plus aspirin (PAS) on atherosclerotic plaque and adipose.

Methods: A total of 31 SD rats with established atherosclerosis were randomly divided into control group (n = 7), high-fat group (n = 4), PS group (n = 8), AS group (n = 5) and PAS group (n = 7). The PS group rats were lavaged with probucol (104.