The HLA-I landscape confers prognosis and antitumor immunity in breast cancer.

Breast cancer is a highly heterogeneous disease with varied subtypes, prognoses and therapeutic responsiveness. Human leukocyte antigen class I (HLA-I) shapes the immunity and thereby influences the outcome of breast cancer. However, the implications of HLA-I variations in breast cancer remain poorly understood.

Guanosine diphosphate-mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with poor prognosis. TNBCs with high homologous recombination deficiency (HRD) scores benefit from DNA-damaging agents, including platinum drugs and poly(ADP-ribose) polymerase (PARP) inhibitors, whereas those with low HRD scores still lack therapeutic options. Therefore, we sought to exploit metabolic alterations to induce HRD and sensitize DNA-damaging agents in TNBCs with low HRD scores.

Bidirectional crosstalk between therapeutic cancer vaccines and the tumor microenvironment: Beyond tumor antigens.

Immunotherapy has rejuvenated cancer therapy, especially after anti-PD-(L)1 came onto the scene. Among the many therapeutic options, therapeutic cancer vaccines are one of the most essential players. Although great progress has been made in research on tumor antigen vaccines, few phase III trials have shown clinical benefits.

[Use of fiber-reinforced chemical curing resin to close the inter-proximate space of the posterior teeth].

Purpose: To investigate the clinical efficacy of using fiber-reinforced chemical curing resin to close the inter-proximate space of the posterior teeth and block the food impaction.

Methods: One hundred and sixty-two patients with food impaction of posterior teeth were selected in this study. The total number of the food impaction was 170.

Expression and significance of VEGF and p53 in degenerate intervertebral disc tissue.

Objective: To investigate the mechanism of expression and significance of vascular endothelial growth factor (VEGF) and p53 in degenerate intervertebral disc tissue.

Methods: Pathological sections collected from 156 patients with lumbar disc herniation after surgery were tested by immunohistochemistry method, for evaluation of the expression of VEGF and p53 in degenerate intervertebral disc tissue.

Results: 98 cases (62.

[Therapeutic effect of electroacupuncture on chronic orchialgia].

Objective: To compare the efficiency difference in chronic orchialgia between electroacupuncture and western medicine and explore the better therapy for chronic orchialgia.

Methods: Eighty-six cases of chronic orchialgia were randomly divided into an electroacupuncture group (56 cases) and an Indomethacin group (30 cases). Except the conventional oral administration of Amitriptyline for anti-depression, electroacupuncture was applied at Shenshu (BL 23), Ciliao (BL 32), Sanyinjiao (SP 6), Taichong (LR 3) and others in electroacupuncture group, and Indometacin suppository anal therapy was used in Indometacin group.

[Clinical observation of 45 cases with radicular cyst treated with non-surgical methods].

Purpose: To observe the clinical effect and the influential factors of non-surgical treatment of radicular cyst.

Methods: A total of 45 cases with radicular cyst were included from 2002 to 2008. They were treated by non-surgical treatment including decompression of cyst cavity or overfilling of the root canal.

[Evaluation of the clinical effect of the teeth with subgingivally involved defect conserved by crown lengthening surgery].

Purpose: To evaluate the clinical effect of the teeth with subgingivally involved defect which were conserved by crown lengthening surgery.

Methods: 62 teeth, with defect subgingivally from 1.5 mm to 4 mm, mobility degree(MD) View Article and Find Full Text PDF

[Experience of repairing alveolar bone defects by collagen membrane and hydroxyapatite and its long-term result].

Purpose: To observe the clinical effect of using the domestic BME-10X medical collagen membrane and hydroxyapatite (HA) in guide tissue regeneration of the bone defects caused by periodontitis and periapical cyst.

Methods: 18 cases with 9 points in 9 teeth with II degree furation involvement, 16 points in 11 teeth with 2 or 3 bone bottom pockets and 6 cases with periapical cyst were chosen in our study. The defect region of alveolar bone was stuffed with HA and covered with collagen membrane.

Pentobarbital selectively blocks supraspinal morphine analgesia. Evidence for GABAA receptor involvement.

The possibility that the GABAA receptor is involved in supraspinal morphine analgesia was investigated in rats using pentobarbital and other GABAA receptor-chloride channel ligands. Inhibition of tail-flick was used as an index of analgesia. Pentobarbital almost completely reversed intracerebroventricular (i.