Dynamic trend in alkaline phosphatase activity in infants aged 0-12 months revealed by an indirect approach.

Objective: Alkaline phosphatase (ALP) is a ubiquitous enzyme in humans that can be used for diagnosing childhood diseases. Infants have the highest rapid growth rate and are susceptible to metabolic bone diseases. In infants, ALP activities exhibit significant month-wise variations, and authoritative standards are lacking.

Age-wise trends in alkaline phosphatase activity in 167,625 Chinese children aged 0-18 years.

Objective: Alkaline phosphatase (ALP) serves as a biomarker for diagnosing several types of diseases in adults; nonetheless, its use is restricted in children because of changes in ALP activity during different physiological phases. The present study aimed to investigate ALP activity and its dynamics in children of different ages to establish the reference values for ALP activity in children.

Methods: Total 167,625 samples of children aged 0-18 years were enrolled in this study.