Publications by authors named "Xiao-Fu Cao"
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality and limited therapeutic options. The immune checkpoint PD1/PD-L1 axis is related to the pathogenesis of pulmonary fibrosis, and upregulated expression levels of PD-L1 have been demonstrated in IPF patients. However, the mechanism of PD-L1 in pulmonary fibrosis is not fully understood.
View Article and Find Full Text PDFAims: Recently, letrozole has been used off-label to treat short pubertal boys. The experience on letrozole effectiveness and safety has been obtained primarily from Caucasian children. A simple extrapolation of the data to Chinese paediatric populations is questionable because of the substantial ethnic differences between the two populations.
View Article and Find Full Text PDFArticle Synopsis
- Researchers studied the effects of human umbilical cord-derived mesenchymal stromal cells (hWJ-MSCs) on aged male mice with sarcopenia caused by hindlimb suspension.
- The study found that mice receiving hWJ-MSCs showed significant improvements in muscle strength, endurance, and muscle mass, along with a decrease in cell death and inflammation.
- Results suggest that hWJ-MSCs could potentially help reduce sarcopenia by activating muscle stem cells and lowering inflammation in older adults.
Article Synopsis
- - The text discusses a case of a 48-year-old woman diagnosed with CPEO plus syndrome, which includes symptoms like limb weakness, ptosis, ophthalmoparesis, and cerebellar dysfunction, indicating a mitochondrial disorder.
- - She underwent various analyses and was treated with supplements such as CoQ10 and vitamin E, while her MRI showed global brain atrophy, and a muscle biopsy indicated ragged red fibers.
- - This case is significant as it's the first report documenting two rRNA mutations linked to CPEO plus, emphasizing the importance of early diagnosis and management to address related symptoms like cerebellar ataxia.