A combined pre- and intra-operative nomogram in evaluation of degrees of liver cirrhosis predicts post-hepatectomy liver failure: a multicenter prospective study.

Background: Adequate evaluation of degrees of liver cirrhosis is essential in surgical treatment of hepatocellular carcinoma (HCC) patients. The impact of the degrees of cirrhosis on prediction of post-hepatectomy liver failure (PHLF) remains poorly defined. This study aimed to construct and validate a combined pre- and intra-operative nomogram based on the degrees of cirrhosis in predicting PHLF in HCC patients using prospective multi-center's data.

Identification of keystone taxa in rhizosphere microbial communities using different methods and their effects on compounds of the host Cinnamomum migao.

Exploring keystone taxa affecting microbial community stability and host function is crucial for understanding ecosystem functions. However, identifying keystone taxa from humongous microbial communities remains challenging. We collected 344 rhizosphere and bulk soil samples from the endangered plant C.

Deep Multiview Module Adaption Transfer Network for Subject-Specific EEG Recognition.

Transfer learning is one of the popular methods to solve the problem of insufficient data in subject-specific electroencephalogram (EEG) recognition tasks. However, most existing approaches ignore the difference between subjects and transfer the same feature representations from source domain to different target domains, resulting in poor transfer performance. To address this issue, we propose a novel subject-specific EEG recognition method named deep multiview module adaption transfer (DMV-MAT) network.

Symbiotic seed germination and seedling growth of mycorrhizal fungi in (Lindl.Ex Hook.) Stein from China.

Similar to other orchid species, (Lindl.ex Hook.) Stein, relies on nutrients provided by mycorrhizal fungus for seed germination and seedling development in the wild owing to a lack of endosperm in its seeds.

Global Transformer and Dual Local Attention Network via Deep-Shallow Hierarchical Feature Fusion for Retinal Vessel Segmentation.

Clinically, retinal vessel segmentation is a significant step in the diagnosis of fundus diseases. However, recent methods generally neglect the difference of semantic information between deep and shallow features, which fail to capture the global and local characterizations in fundus images simultaneously, resulting in the limited segmentation performance for fine vessels. In this article, a global transformer (GT) and dual local attention (DLA) network via deep-shallow hierarchical feature fusion (GT-DLA-dsHFF) are investigated to solve the above limitations.

FAIR Genomes metadata schema promoting Next Generation Sequencing data reuse in Dutch healthcare and research.

The genomes of thousands of individuals are profiled within Dutch healthcare and research each year. However, this valuable genomic data, associated clinical data and consent are captured in different ways and stored across many systems and organizations. This makes it difficult to discover rare disease patients, reuse data for personalized medicine and establish research cohorts based on specific parameters.

Seed Dormancy Release and Germination Requirements of , an Endangered and Rare Woody Plant in Southwest China.

Seed dormancy is a complex adaptive trait of plants that are influenced by several physiological and environmental factors. The endangered plant is also known to exhibit seed dormancy and low germination, which may influence its regeneration; however, these characteristics remain unexplored. To our knowledge, this study is the first to examine the type of dormancy and improve the germination percentage of seeds.

[Preparation of Functional Attapulgite Composite and Its Adsorption Behaviors for Congo Red].

Heavy metal ion wastewater poses a serious threat to human health and the environment. The adsorption method is an important method to remove heavy metal ions from heavy metal wastewater. Magnetic attapulgite (ATP) composite nanomaterials with excellent adsorption properties were prepared by grafting the FeO nanoparticles and using 3-aminopropyl triethoxy silane (APTES) modification.

Isolation and identification of beneficial orchid mycorrhizal fungi in ().

Seed germination and seedling development in nearly all orchid species rely on a symbiotic relationship with mycorrhizal fungi; however, this is not the case with all mycorrhizal fungi. This study aims to provide an understanding about the important role of mycorrhiza in seed germination and growth of . Therefore, we isolated and identified endophytic fungi from the roots of wild .

Spatio-Temporal-Spectral Hierarchical Graph Convolutional Network With Semisupervised Active Learning for Patient-Specific Seizure Prediction.

Graph theory analysis using electroencephalogram (EEG) signals is currently an advanced technique for seizure prediction. Recent deep learning approaches, which fail to fully explore both the characterizations in EEGs themselves and correlations among different electrodes simultaneously, generally neglect the spatial or temporal dependencies in an epileptic brain and, thus, produce suboptimal seizure prediction performance consequently. To tackle this issue, in this article, a patient-specific EEG seizure predictor is proposed by using a novel spatio-temporal-spectral hierarchical graph convolutional network with an active preictal interval learning scheme (STS-HGCN-AL).

Doxorubicin resistance induces IL6 activation in the colon cancer cell line LS180.

Despite improvements in the development of drugs for the treatment of cancer, drug resistance remains a major obstacle. In colon cancer, following an initially promising response, patients develop drug resistance, which impacts the efficacy and halts the response of cancerous cells towards drugs. In the present study, a phosphatase and tensin homolog (PTEN) knockdown model of LS180 cells, doxorubicin-resistant models of LS180 cells as well as doxorubicin-resistant LS180 (PTEN) knockdown model were established.

Clinicopathological factors associated with HER2-positive gastric cancer: A meta-analysis.

Background: The treatment of patients with advanced gastric cancer remains a most challenging task in the clinical practice. Recently, targeted therapies have significantly impacted the treatment strategy for many common malignancies. The use of trastuzumab, a monoclonal antibody against human epidermal growth factor receptor 2 (HER2; also known as ERBB2), plus chemotherapy proved to improve median overall survival in patients with advanced gastric cancer, compared with chemotherapy alone in Trastuzumab for Gastric Cancer (ToGA) trial.

Clinical application of entire gastrointestinal barium meal combined with multi-temporal abdominal films in patients with intestinal neuronal dysplasia type B.

Objective: To report and evaluate the application of entire gastrointestinal barium meal combined with multi-temporal abdominal films in the diagnosis of patients with intestinal neuronal dysplasia type B (IND type B).

Methods: Thirty-six patients with symptoms of long-standing constipation were enrolled in this study. The study took place at the Department of General Surgery, Xiangyang Central Hospital, Hubei Province, China from July 2007 to October 2012.

Time-varying linear and nonlinear parametric model for Granger causality analysis.

Statistical measures such as coherence, mutual information, or correlation are usually applied to evaluate the interactions between two or more signals. However, these methods cannot distinguish directions of flow between two signals. The capability to detect causalities is highly desirable for understanding the cooperative nature of complex systems.

[PTEN induces anoikis through its phosphatase activity in hepatocellular carcinoma cells].

Objective: To investigate the effect and mechanisms of tumor suppressor gene PTEN on the induction of anoikis of hepatocellular carcinoma SMMC-7721 cells.

Methods: SMMC-7721 cells were transfected with GFP plasmids containing wild-type PTEN or phosphatase inactivating mutant PTEN (C124A-PTEN) in vitro; The PTEN expression and the phosphorylation levels of focal adhesion kinase (FAK) and protein kinase B (PKB/Akt) were detected by Western blotting; Flow cytometry assay and laser scanning confocal microscopy were used to analyze apoptosis in adherent and non-adherent cells.

Results: Compared with the control, PTEN expression in the cells transfected with wild-type PTEN increased to 248%, while the phosphorylation level of FAK and Akt decreased 65.

Tumor angiogenesis and its clinical significance in pediatric malignant liver tumor.

Aim: To investigate the expression of vascular endothelial growth factor (VEGF) and microvascular density (MVD) count in pediatric malignant liver tumor and their clinical significances.

Methods: Fourteen children with malignant liver tumors including seven hepatocellular carcinomas (HCCs), five hepatoblastomas, one malignant mesenchymoma and one rhabdomyosarcoma were studied. Twelve adult HCC samples served as control group.

[PTEN induces apoptosis and up-regulates p53 expression in HepG2 cells].

Objective: To investigate the effects of tumor suppressor gene PTEN on apoptosis and protein expression of p53 in HepG2 cells, as well as to explore its mechanisms.

Methods: HepG2 cells were transfected with GFP plasmids containing wild-type PTEN or G129E-PTEN and C124A-PTEN in vitro. Both the expression of wild-type p53 and the phosphorylation of protein kinase B (PKB/Akt) and focal adhesion kinase (FAK) were detected by Western blotting.

Angiogenesis in rabbit hepatic tumor after transcatheter arterial embolization.

Aim: To investigate the effect of transcatheter arterial embolization (TAE) on angiogenesis of hepatic tumor.

Methods: Twenty New Zealand White rabbits were randomly divided into two groups of 10 each and VX2 carcinoma was implanted in the left medial lobes of the livers. Fourteen days later, a silicon catheter was inserted into the left hepatic artery of rabbit with VX2 hepatic tumor and infusion was performed via the hepatic artery using Lipiodol (the TAE group) or saline (the control group).