Effectiveness of Parecoxib Sodium Combined with Transversus Abdominis Plane Block for Pain Management After Hepatectomy for Hepatocellular Carcinoma: A Prospective Controlled Study.

BACKGROUND This study aimed to investigate the effectiveness of perioperative parecoxib sodium combined with transversus abdominis plane (TAP) block on postoperative pain management following hepatectomy in patients with hepatocellular carcinoma (HCC). MATERIAL AND METHODS One hundred patients with HCC who underwent hepatectomy were randomized into a study group (n=51) and a control group (n=49). The study group received 40 mg of parecoxib sodium 30 minutes before anesthetic induction, and 150 mg of 0.

Triple-functional core-shell structured upconversion luminescent nanoparticles covalently grafted with photosensitizer for luminescent, magnetic resonance imaging and photodynamic therapy in vitro.

Upconversion luminescent nanoparticles (UCNPs) have been widely used in many biochemical fields, due to their characteristic large anti-Stokes shifts, narrow emission bands, deep tissue penetration and minimal background interference. UCNPs-derived multifunctional materials that integrate the merits of UCNPs and other functional entities have also attracted extensive attention. Here in this paper we present a core-shell structured nanomaterial, namely, NaGdF(4):Yb,Er@CaF(2)@SiO(2)-PS, which is multifunctional in the fields of photodynamic therapy (PDT), magnetic resonance imaging (MRI) and fluorescence/luminescence imaging.

Luminescent lanthanide (Eu3+, Tb3+) hybrids with 4-vinylbenzeneboronic acid functionalized Si-O bridges and beta-diketones.

4-Vinylphenylboronic acid ligand (VPBA) is functionalized with two crosslinking reagents (3-(triethoxysilyl)-propylisocyanate [TEPIC] and 3-(trimethoxysilyl) propyl methacrylate [TMPMA]) to achieve the two special molecular bridge VPBA-TEPIC and VPBA-TMPMA. Meanwhile, beta-diketone ligands (2-thenoyltrifluoroacetone [TTA], acetyl acetone [ACAC]) as the second ligands play the role of the main energy donor, which absorb abundant energy in ultraviolet-visible extent and then transfer the energy to the corresponding lanthanide ions (Eu(3+), Tb(3+)) to sensitize their emission of them. Eight binary and ternary Eu(3+), Tb(3+) hybrids with VPBA-TEPIC (VPBA-TMPMA) and TTA (ACAC) have been constructed, whose photoluminescence properties are studied in depth and suggest that the ternary hybrids show the favorable characteristic luminescent properties (longer lifetime and higher quantum efficiency).

Rare earth centered hybrid materials: Tb3+ covalently bonded with La3+, Gd3+, Y3+ through sulfonamide bridge and luminescence enhancement.

The organic ligand 5-sulfosalicylic acid (SSA) is grafted by (3-aminopropyl) triethoxysilane (APTES) to achieve functionalized sulfonamide bridge (SSA-Si) which can both coordinate to Ln(3+) to form luminescent center and link inorganic Si-O network through hydrolysis and condensation reaction with tetraethoxysilane (TEOS). Thus the organic-inorganic hybrid is obtained with sol-gel method. The organic polymer poly-methyl methacrylate (PMMA) acts as another precursor is prepared through the direct addition polymerization of MMA monomer in the presence of the initiator BPO (benzoyl peroxide).

Photoactive binary and ternary lanthanide (Eu3+, Tb3+, Nd3+) hybrids with p-tert-butylcalix[4]arene derived Si-O linkages and polymers.

Through the reaction between the hydroxyl groups of p-tert-butylcalix[4]arene derivatives (Calix-Br, Calix-AC) and the isocyanate group of 3-(triethoxysilyl)-propyl isocyanate (TEPIC), two novel kinds of functional polysilsesquioxanes linkage precursors Calix-Br-Si and Calix-AC-Si have been synthesized. Then the binary and ternary hybrid materials are assembled with chemical bonds, which are composed of lanthanide ion centres (Eu(3+), Tb(3+), Nd(3+)), precursors Calix-Br-Si or Calix-AC-Si and the organic polymers [poly(4-vinylpyridine) (PVPD) or poly(methyl methacrylate) (PMMA)]. The composition and physical properties of these hybrids are characterized, especially comparing the photoluminescent characters.

Binary and ternary lanthanide centered hybrid polymeric materials: coordination bonding construction, characterization, microstructure and photoluminescence.

A functional molecular bridge (named as HBA-TEPIC) (HBA = 1,4-hydroxybenzoic acid, TEPIC = 3-(triethoxysilyl)-propyl-isocyanate) was achieved through the hydrogen transfer nucleophilic addition reaction. Firstly, the molecular precursors coordinate to lanthanide ions (Eu3+ and Tb3+) and then form the covalently bonded Si-O network to obtain the polymeric hybrid material (HBA-TEPIC-RE). Secondly, the synthesized polymers PMMA and PMAALM and commercial PVP (polyvinylpyrrolidone) were further introduced into the inorganic network to obtain hybrids with the organic chains and inorganic networks together (HBA-TEPIC-RE-PVP/PMAA/PMAALM).

Covalently bonded assembly of lanthanide/silicon-oxygen network/polyethylene glycol hybrid materials through functionalized 2-thenoyltrifluoroacetone linkage.

2-Thenoyltrifluoroacetone (TTA) used as the organic ligand and the poly(ethylene glycol) (PEG400 with the molecular weight of 380-430) used as the network precursor were grafted onto the coupling agent 3-(triethoxysilyl)-propyl isocyanate (TEPIC), respectively, to construct two precursors TTA-Si and PEG-Si. Then the precursor TTA-Si and the terminal ligand 1,10-phenanthroline (Phen) have coordinated to the rare earth ions by the carbonyl group or nitrogen atom to obtain binary or trinary hybrid polymeric materials after hydrolysis and copolycondensation between the tetraethoxysilane (TEOS), water molecules, and the network precursor PEG-Si via the sol-gel process. The terminal ligand 1,10-phenanthroline (Phen) was used to investigate the difference of photophysical and luminescent properties between binary and trinary hybrid materials, and the network precursor PEG-Si was induced to show its influence on microstructure and thermal properties.

Hybrid materials of lanthanide centers/functionalized 2-thenoyltrifluoroacetone/silicon-oxygen network/polymeric chain: coordination bonded assembly, physical characterization, and photoluminescence.

2-Thenoyltrifluoroacetone (TTA) was grafted onto the coupling agent 3-(triethoxysilyl)-propyl isocyanate (TEPIC) through a hydrogen transfer addition reaction to construct the multifunctional bridge precursor. Other kinds of polymeric precursors (PVPD, PMAA, and PVPDMAA) were synthesized through the addition polymerization reactions using the monomer 4-vinylpyridine and methacrylic acid as the raw materials. The lanthanide compound was then assembled by the coordination effect between precursors and europium ions with the carbonyl, carboxyl groups, or nitrogen atoms.

Rare-earth/inorganic/organic polymeric hybrid materials: molecular assembly, regular microstructure and photoluminescence.

2-Hydroxynicotinic acid (HNA) was grafted by 3-(triethoxysilyl)propyl isocyanate (TEPIC) to achieve the molecular precursor HNA-Si through the hydrogen-transfer nucleophilic addition reaction between the hydroxyl group of HNA and the isocyanate group of TEPIC. Then, a chemically bonded rare-earth/inorganic polymeric hybrid material (A) was constructed using HNA-Si as a bridge molecule that can both coordinate to rare-earth ions (HNA-Si-RE) and form an inorganic Si-O network with tetraethoxysilane (TEOS) after cohydrolysis and copolycondensation processes. Further, three types of novel rare-earth/inorganic/organic polymeric hybrids (B-D) were assembled by the introduction of three different organic polymeric chains into the above system.

Photophysical properties of terbium molecular-based hybrids assembled with novel ureasil linkages.

Three silica-based organic-inorganic hybrid systems composed of hydroxyl aromatic derivatives (2-acetylphenol [HAP], 2-hydroxy-3-methylbenzoic acid [HMBA], 3-hydroxy-meta-phthalic acid [HMPHTH] complexes) were prepared via a sol-gel process. The active hydroxyl groups of the three ligands grafted by 3-(triethoxysilyl)-propyl isocyanate (TESPIC) through hydrogen transfer addition reaction were used as multi-functional bridge components, which can coordinate to Tb3+ with carbonyl groups, strongly absorb ultraviolet light and effectively transfer energy to Tb3+ through their triplet excited state, as well as undergo polymerization or crosslinking reactions with tetraethoxysilane (TEOS), for anchoring terbium ions to silica backbone. NMR, FT-IR, UV-vis absorption, luminescence spectroscopy was used to investigate the obtained hybrid material.