Correlation between glycated hemoglobin A1c, urinary microalbumin, urinary creatinine, β2 microglobulin, retinol binding protein and diabetic retinopathy.

Background: Retinopathy is the most common microvascular disease of type 2 diabetes, and seriously threatens the life, health and quality of life of patients. It is worth noting that the development of diabetic retinopathy (DR) can be hidden, with few symptoms. Therefore, the preliminary screening of diabetic patients should identify DR as soon as possible, delay disease progression, and play a vital role in its diagnosis and treatment.

Association of [H]-MRS quantified liver fat content with glucose metabolism status.

Background: Previous literatures have implied that the liver fat deposition plays a crucial role in the development and progression of insulin resistance. In the present study, we aimed to investigate the association of liver fat content (LFC) with glucose metabolism status in the population of newly diagnosed type 2 diabetes mellitus (nT2DM), prediabetes mellitus (PDM) and normal controls (NC), and assessing if the LFC could as an indicator for the prediction of T2DM.

Methods: A total of 242 subjects (including 141 nT2DM patients, 48 PDM subjects and 53 NC) were enrolled.

The neurovascular protective effect of alogliptin in murine MCAO model and brain endothelial cells.

Endothelial damage and blood brain barrier disruption contribute to ischemic stroke and brain injury. Gliptins are a novel class of treatment agents for diabetes, and recent studies have linked the use of gliptins to neuroprotection. Alogliptin is a type of orally available gliptin that was approved for clinical use by the FDA in 2013.

Apelin-13 deficiency alters cortical bone geometry, organic bone matrix, and inhibits Wnt/β-catenin signaling.

Adipokines play key roles in the regulation of obesity, type 2 diabetes mellitus, and bone growth. As a newly discovered hormone in the adipokines family, the precise role of Apelin-13 on bone metabolism is not yet clear. Apelin-13 and 25(OH)D3 expression were detected in freshly isolated serum of healthy individuals and osteoporosis patients with ELISA method.

Contrast-induced nephropathy in patients with diabetes mellitus between iso- and low-osmolar contrast media: A meta-analysis of full-text prospective, randomized controlled trials.

Purpose: This study was conducted to compare iso-osmolar contrast medium, iodixanol, with low-osmolar contrast media (LOCM) for assessing contrast-induced nephropathy (CIN) incidence, exclusively in the diabetic population.

Method: A systematic search was conducted for full-text, prospective, randomized controlled trials (RCTs). The primary outcome was incidence of CIN.

CD9 modulates proliferation of human glioblastoma cells via epidermal growth factor receptor signaling.

The tetraspanin CD9 has previously been shown to be involved in various cellular activities, including proliferation and migration. In addition, CD9 has been shown to be associated with epidermal growth factor receptor (EGFR). A common characteristic of glioblastoma multiforme histology is EGFR amplification, which affects signal transduction processes.

Diagnostic accuracy of intracellular mycobacterium tuberculosis detection for tuberculous meningitis.

Rationale: Early diagnosis and treatment of tuberculous meningitis saves lives, but current laboratory diagnostic tests lack sensitivity.

Objectives: We investigated whether the detection of intracellular bacteria by a modified Ziehl-Neelsen stain and early secretory antigen target (ESAT)-6 in cerebrospinal fluid leukocytes improves tuberculous meningitis diagnosis.

Methods: Cerebrospinal fluid specimens from patients with suspected tuberculous meningitis were stained by conventional Ziehl-Neelsen stain, a modified Ziehl-Neelsen stain involving cytospin slides with Triton processing, and an ESAT-6 immunocytochemical stain.

[Distribution of Bt protein in transgenic cotton soils].

A pot experiment with red soil, yellow brown soil, and yellow cinnamon soil was conducted to detect the Bt protein content in rhizosphere and non-rhizosphere soils at different growth stages of transgenic Bt cotton and common cotton by using enzyme linked immunosorbent assay (ELISA). With the planting of transgenic Bt cotton, the Bt protein content in rhizosphere soil was significantly higher than that in non-rhizosphere soil; while in common cotton soils, there was no significant difference in the Bt protein content between rhizosphere soil and non-rhizosphere soil. At bud stage of transgenic Bt cotton, the Bt protein content in rhizosphere soil was in the order of yellow cinnamon soil > yellow brown soil > red soil, being 144% 121%, and 238% of that in common cotton rhizosphere soil; at florescence stage of transgenic Bt cotton, the Bt protein content in rhizosphere soil was in the order of yellow brown soil > yellow cinnamon soil > red soil, being 156% , 116% , and 197% of that in common cotton rhizosphere soil, respectively.