[Comparative study of two elastic fixation systems in single-segment lumbar disc herniation surgery for nucleus pulposus extraction].

Objective: To investigate the clinical application of two elastic pedicle internal fixation systems in single-segment lumbar disc herniation fenestration.

Methods: A retrospective analysis of 64 patients with lumbar intervertebral disc herniation treated by surgery from June 2019 to March 2021. According to the different elastic fixation systems placed during the operation, the patients were divided into ordinary pedicle screw elastic rod link group (elastic rod group) and a special elastic pedicle screw rigid rod fixed connection group (elastic screw group).

An Eight-CpG-based Methylation Classifier for Preoperative Discriminating Early and Advanced-Late Stage of Colorectal Cancer.

Aim: To develop and validate a CpG-based classifier for preoperative discrimination of early and advanced-late stage colorectal cancer (CRC).

Methods: We identified an epigenetic signature based on methylation status of multiple CpG sites (CpGs) from 372 subjects in The Cancer Genome Atlas (TCGA) CRC cohort, and an external cohort (GSE48684) with 64 subjects by LASSO regression algorithm. A classifier derived from the methylation signature was used to establish a multivariable logistic regression model to predict the advanced-late stage of CRC.

[Non-angiogenic functions of vascular endothelial growth factor].

Vascular endothelial growth factor (VEGF or VEGF-A), also named as vascular permeable factor (VPF), is a multi-functional bio-macromolecule belonging to the family of secreted glycoprotein growth factor. VEGF can induce a variety of cellular responses through two high-affinity tyrosine kinases, VEGFR1 and VEGFR2. VEGF plays a key role in the angiogenesis and development in the embryo phase, promoting the proliferation, migration, tube formation and survival of the vascular endothelial cells.