Blood lead and cadmium levels are negatively associated with bone mineral density in young female adults.

Background: The organ toxicities of lead and cadmium have been extensively studied; however, studies of their toxic effects on bone remain limited, especially in young adults. The objective of this study was to examine the associations of blood lead levels (BLL) and blood cadmium levels (BCL) with bone mineral density (BMD) among young adults.

Methods: We performed a cross-sectional study using the National Health and Nutrition Examination Survey 2011-2018 database.

Association between plasma total homocysteine level within normal range and bone mineral density in adults.

Background: Growing evidence indicates that homocysteine is a noteworthy marker for general health status. However, research regarding plasma total homocysteine (tHcy) levels and bone mineral density (BMD) is sparse and controversial. Hence, we aimed to investigate the association between plasma tHcy level within normal range and lumbar BMD in adults.

Discovery of novel pyruvate dehydrogenase kinases inhibitors by screening of an in-house small molecule library for anti-lung cancer therapeutics.

Pyruvate dehydrogenase kinases (PDKs) are widely over-expressed in various human solid cancers, making them attractive therapeutic targets for cancer treatment. Herein, we report the identification of structurally novel PDKs inhibitors by screening of an in-house small molecule library. Biochemical assay indicated that the identified compounds 1-4 inhibited PDK1 activity with EC values of 0.

[Studies on the photo-stability of poly p-(phenylene vinylene)].

The photo-stability of both MDMO-PPV film and MEH-PPV film, as irradiated under different conditions, and in the presence and absence of oxygen and visible light luminance, were studied by UV-Vis spectra and fluorescence spectra respectively. The maximum absorbance of them was at 500 nm, while the maximum fluorescence intensity of them were at 580 and 589 nm, respectively. In the presence of both oxygen and light irradiation, the fluorescence intensity was decreased and the films were damaged.