Blocking P2X4 purinergic receptor attenuates alcohol-related liver fibrosis by inhibiting hepatic stellate cell activation through PI3K/AKT signaling pathway.

Alcoholic liver fibrosis（ALF）, as a liver disease caused by long-term alcoholism, attracts international attention. Activation of hepatic stellate cells is a key step in the development of alcoholic-associated liver fibrosis. Increasing studies have shown that P2X4 receptor, as a component of purinoceptor family in adenosine pathway, plays an important role in numerous liver diseases.

Shufeng Jiedu capsule inhibits inflammation and apoptosis by activating A2AAR and inhibiting NF-κB to alleviate LPS-induced ALI.

Ethnopharmacological Relevance: Shufeng Jiedu capsule (SFJDC) is a pure form of traditional Chinese medicine (TCM) that contains eight medicinal plants. Known for its anti-inflammatory and antipyretic effects, it is mostly used to treat upper respiratory tract infections and other infectious diseases, such as colds, pharyngitis, laryngitis, and tonsillitis. Both acute lung injury (ALI) and COVID-19 are closely related to lung damage, primarily manifesting as lung inflammation and epithelial cell damage.

[Differential neuronal firing in globus pallidus internus of patients with Parkinson's disease and dystonia].

Objective: To explore the neuronal activity in globus pallidus internus in patients with Parkinson's disease (PD) and dystonia.

Methods: Thirteen patients with Parkinson's disease and eight with dystonia undergoing stereotactic surgery of globus pallidus internus were studied. Microrecording in globus pallidus internus and electromyography on contralateral limbs to surgery were simultaneously performed.