Publications by authors named "Xiao-Die Xu"
Article Synopsis
- Cell senescence is a key mechanism of aging, and while its role in tissues like fat, pancreas, and liver in relation to type 2 diabetes is established, its direct effects on neurons are still unclear.
- In this study, researchers created a high glucose and palmitic acid (HGP) environment to simulate diabetes in neuronal cells and found that this condition triggered significant senescence-like traits in the neurons, linked to changes in specific proteins and cellular processes.
- The findings suggest that diabetes can directly lead to neuronal senescence by increasing NRSF/REST levels, which then disrupts the mTOR-autophagy pathway, indicating a potential target for future therapies.
Diabetes is one of the well-established risk factors of stroke and is associated with a poor outcome in patients with stroke. Previous studies have shown that the expression of neuron restrictive silencer factor (NRSF) is elevated in diabetes as well as ischemic stroke. However, the role of NRSF in regulating an outcome of diabetic ischemic stroke has not been completely understood.
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- The study investigates the therapeutic effects of a novel compound, palmitic acid (5-PAHSA), on neurological dysfunction related to Type 2 diabetes by focusing on autophagy.
- In both in vitro (PC12 cells) and in vivo (DB/DB mice) experiments, 5-PAHSA was administered and showed promising results in decreasing oxidative stress and inflammation, although it did not significantly improve glucose metabolism.
- The findings suggest that while 5-PAHSA enhances autophagy and lowers specific inflammatory markers, it does not affect apoptosis or cognitive functions in diabetic mice.
Increased NRSF/REST in anterior cingulate cortex contributes to diabetes-related neuropathic pain.
Biochem Biophys Res Commun
June 2020
Diabetic neuropathic pain is one of the most common complications of diabetes. Mechanisms underlying the central modulation are still unclear. Here, we investigated the role of the neuron-restricted silencing factor (NRSF/REST) in diabetic-related neuropathic pain.
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