Elevated Plasma Levels of Drebrin in Glaucoma Patients With Neurodegeneration.

Glaucoma is an optic neuropathy characterized by progressive degeneration of retinal ganglion cells (RGCs). Aberrations in several cytoskeletal proteins, such as tau have been implicated in the pathogenesis of neurodegenerative diseases, could be initiating factors in glaucoma progression and occurring prior to axon degeneration. Developmentally regulated brain protein (Drebrin or DBN1) is an evolutionarily conserved actin-binding protein playing a prominent role in neurons and is implicated in neurodegenerative diseases.

Circulating S100A8/A9 Levels Reflect Intraocular Inflammation in Uveitis Patients.

To investigate whether there is an association between circulating S100A8/A9 levels and uveitis activity. A total of 549 plasma samples were collected from uveitis patients and non-uveitic controls. S100A8/A9 plasma levels were elevated in uveitis patients compared to non-uveitic controls ( < 0.

Integration of microRNA and mRNA expression profiles in the skin of systemic sclerosis patients.

MicroRNAs (miRNAs) play important roles in the fibrosis of systemic sclerosis (SSc). However, the underlying miRNA-mRNA regulatory network is not fully understood. A systemic investigation of the role of miRNAs would be very valuable for increasing our knowledge of the pathogenesis of SSc.