Publications by authors named "Xiao-Chong Guo"
Beclin 1 is involved in autophagy, differentiation, apoptosis and cancer progression, and functions as a haploinsufficient tumor suppressor gene. The aim of the present study was to elucidate the function of Beclin 1 in colon cancer. A Beclin 1-expressing plasmid was transfected into HCT-15 and HCT-116 cells, and the phenotypes and associated molecules were determined.
View Article and Find Full Text PDFObjective: To investigate Homer protein expression after focal brain contusion and explore the relationship between expression and injury time.
Methods: Focal brain contusion in rats was established and Homer protein expression in brain at different injury intervals after contusion was detected by immunohistochemistry and Western blotting.
Results: A small amount of Homer positive expression cells were detected in control group, sham operated group and experimental group (0.
[Expression of matrix metalloproteinase-3 after brain contusion in rats].
Fa Yi Xue Za Zhi
February 2009
Objective: To investigate the expression of matrix metalloproteinase-3 after brain contusion and its applicability for estimating the age of brain contusion.
Methods: Rats had been divided into three groups: control group, sham operation group and brain contusion group. The expression of matrix metalloproteinase-3 at different time was detected by immunohistochemistry and Western blot.
Article Synopsis
- This study examined how MMP-3, a protein, can be used to determine the age of brain contusions in rats after creating a brain injury model.
- MMP-3 expression was measured using immunochemistry and Western blot techniques at various time points post-contusion (from 6 hours to 14 days), showing an increase in MMP-3 levels that peaked at 5 days.
- The findings suggest that MMP-3 is not present in healthy brains but appears soon after a traumatic brain injury, indicating its potential use as a forensic marker to estimate the age of such injuries.
Objective: To establish a new animal model of grading skeletal muscle contusions that could be controllable and repetitive.
Methods: The rats' gastrocnemius was injured by a new weight-dropping device designed. The force acting on gastrocnemius with a comparatively constant duration and inducing elastic deformation of the gastrocnemius was expressed with velocity (v) and deformation (DF).