Publications by authors named "Xiao-Bo Pu"
Objective: To analyse the characteristics and mortality of hypertrophic cardiomyopathy (HCM) patients with different body compositions.
Methods: In this study, 530 consecutive patients with HCM at West China Hospital were studied from November 2008 to May 2016. An equation based on body mass index (BMI) was used to obtain the Percent body fat (BF) and lean mass index (LMI).
Background: We aimed to investigate whether the pressure injury risk mediates the association of left ventricular ejection fraction (LVEF) with all-cause death in patients with acute myocardial infarction (AMI) aged 80 years or older.
Methods: This retrospective cohort study included 677 patients with AMI aged 80 years or older from a tertiary-level hospital. Pressure injury risk was assessed using the Braden scale at admission, and three risk groups (low/minimal, intermediate, high) were defined according to the overall score of six different variables.
Article Synopsis
- Left ventricular hypertrophy (LVH) is common in obese individuals, and both conditions are linked to subclinical left ventricle dysfunction; the study examines their combined impact on mortality in coronary artery disease (CAD) patients.* -
- Out of 2243 participants, 25% exhibited higher body fat, and nearly 47% had LVH; their 2.2-year follow-up revealed that those with both higher body fat and LVH had the highest mortality rates (8.2%).* -
- Findings indicate that increased body fat significantly raises the risk of all-cause death only in patients with LVH, highlighting the importance of considering both factors in assessing mortality risk in CAD patients.*
Article Synopsis
- The study examined the role of gender in the presentation and outcomes of hypertrophic cardiomyopathy (HCM) in 576 Chinese patients, highlighting differences between males and females.
- Female patients were older and had more severe symptoms at diagnosis compared to male patients, along with higher left ventricular outflow tract gradients.
- Although there were no significant differences in overall or cardiovascular mortality rates between genders, females had a higher rate of being rehospitalized due to heart failure.
Background: Contemporary heart failure medications have led to considerable improvement in the survival of patients with heart failure. However, limited evidence is available regarding the effect of those medications in patients with idiopathic dilated cardiomyopathy (IDCM), particularly in China. We sought to analyze the trends in clinical characteristics and the prescription rate of recommended therapies and its prognostic impact in patients with IDCM.
View Article and Find Full Text PDFBackground: Ageing is a risk factor for both coronary artery disease (CAD) and reduced renal function (RRF), and it is also associated with poor prognosis in patients with CAD or RRF. However, little is known about whether the impact of RRF on clinical outcomes are different in CAD patients at different age groups. This study aimed to investigate whether ageing influences the effect of RRF on long-term risk of death in patients with CAD.
View Article and Find Full Text PDFFew data are available regarding the prevalence and clinical significance of right ventricular systolic dysfunction (RVSD) in hypertrophic cardiomyopathy (HC) patients. This study aimed to evaluate right ventricular (RV) systolic function by cardiovascular magnetic resonance and explore the prevalence and prognostic significance of RVSD in HC patients. A total of 226 patients with HC assessed by cardiovascular magnetic resonance were included in this retrospective study.
View Article and Find Full Text PDFBackground: Exercise-based cardiac rehabilitation (CR) has been recognized as an essential component of the treatment for coronary heart disease (CHD). Determining the efficacy of modern alternative treatment methods is the key to developing exercise-based CR programs.
Methods: Studies published through June 6, 2016, were identified using MEDLINE, EMBASE, and the Cochrane Library.
Background: The impact of renal function on the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) remains unclear in coronary artery disease (CAD). This study sought to investigate the value of using NT-proBNP level to predict prognoses of CAD patients with different estimated glomerular filtration rates (eGFRs).
Methods: A retrospective analysis was conducted from a single registered database.
Background: Elderly patients with coronary artery disease (CAD) frequently complicated with more cardiovascular risk factors, but received fewer evidence-based medications (EBMs). This study explored the association of EBMs compliance in different age groups and the risk of long-term death.
Methods: A retrospective analysis was conducted from a single registered database.
Background: TAVR is a rapidly spreading treatment option for severe aortic valve stenosis. Significant coronary artery disease (CAD) is present in 40% to 75% of patients undergoing TAVR. However, when to treat the concomitant coronary artery lesions is controversial.
View Article and Find Full Text PDFRationale: Coarctation of aorta in adulthood is usually complicated by other cardiovascular anomalies, posing great technical challenge for intervention.
Patient Concerns: Here, we report an extremely rare case of aortic arch coarctation combined with a poststenotic biloculated calcified aneurysm and hypoplastic left subclavian artery.
Interventions: First, an extra-anatomic bypass was established, along with narrowing of aorta just proximal and distal to the aneurysm.
Background: Statins therapy in the secondary prevention of coronary artery disease (CAD) is associated with a lower risk of adverse cardiovascular events. However, little is known regarding the association of elderly patients with nutritional risk on statin therapy.
Aims: To investigate whether older patients with CAD who were at nutritional risk gain similar survival benefit from statins therapy as their counterparts without nutritional risk.
Frequent premature atrial complexes (PACs) are universal in the general population; however, their clinical significance is unclear. We hypothesize that frequent PACs are associated with increased risk of stroke and death. The PubMed (from 1966 to April 2017) and Embase (from 1974 to April 2017) databases were searched for longitudinal studies that reported the relation of PACs with incidence of stroke and death with various etiologies.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed statin prescription trends among nearly 52,000 patients with atherosclerotic cardiovascular disease (ASCVD) in China from 2008 to 2014, highlighting a 58.8% overall prescription rate for these medications at discharge.
- It showed a consistent increase in statin prescriptions across various subtypes of ASCVD, including coronary artery disease and cerebrovascular disease, with prescribed rates for cerebrovascular disease and peripheral arterial disease remaining notably lower.
- The findings suggest a need for improved awareness and medical care integration in China to optimize statin utilization and address disparities in prescription rates among different ASCVD subtypes.
Article Synopsis
- A study analyzed the use of optimal medical therapy (OMT) in 3,176 coronary artery disease (CAD) patients, finding that only 39.8% were on OMT at discharge, influenced by factors like prior OMT usage and the discharge department.
- The research showed that OMT significantly reduced all-cause mortality, with a lower risk ratio (HR: 0.65) and more pronounced survival benefits noted in male patients with acute coronary syndrome (ACS).
- The effectiveness of OMT increased over time, especially after 24 months, and a four-drug combination therapy was more beneficial for ACS patients compared to a three-drug regimen, though this was not the case for stable
Fibrinogen (Fib) is considered to be a potential risk factor for the prognosis of patients with acute coronary syndrome (ACS), but it is unclear whether Fib level have synergistic effects to enhance the prognostic value of the GRACE score in patients with ACS. A retrospective analysis was conducted from a single registered database. 2253 consecutive patients with ACS confirmed by coronary angiography were enrolled and were grouped into 3 categories by the tertiles of admission plasma Fib levels.
View Article and Find Full Text PDFFew studies to date address the predictive ability of CHADS-VASc and RCHADS in CAD patients. Our aim is to investigate the prognostic performance of CHADS, CHADS-VASc and RCHADS scores in patients with coronary artery disease (CAD). Angiographically obstructive CAD patients were enrolled.
View Article and Find Full Text PDFWe present a case of aortic coarctation combined with ascending-descending aorta dilatation and concomitant aortic valve regurgitation. The technique involved using endovascular stenting, a two-stage balloon dilation procedure post-stent implantation and a Bentall procedure.
View Article and Find Full Text PDFObjectives: Our aim was to investigate whether the presence of metabolic syndrome (MetS) and diabetes mellitus (DM) influenced the N-terminal pro-B-type natriuretic peptide (NT-proBNP) level and its prognostic performance in coronary artery disease (CAD).
Patients And Methods: The present study enrolled a total of 1638 CAD patients. Multivariate regression analyses were carried out to relate NT-proBNP to metabolic components, nondiabetic MetS, DM, and MetS score.
Backgrounds: The relation between serum total bilirubin (TBi) and mortality in patients with established coronary artery disease (CAD) remains undefined. We try to investigate the role of the subtypes of CAD in the association.
Methods: A total of 3013 patients with angiographically obstructive CAD were enrolled.
Background: There is a controversy surrounding the correlation between fibrinogen (Fib) level and prognosis of coronary artery disease (CAD). We try to investigate the role of the subtypes of CAD in this controversy.
Methods: A retrospective analysis was conducted from a single center CAD registered database.
Our aim was to illustrate the effect of higher activated clotting time (ACT) values versus lower ACT values on thrombotic or hemorrhagic events in coronary atherosclerotic heart disease (CHD) patients undergoing percutaneous coronary intervention (PCI). PubMed, Embase, Web of Science, and Cochrane Library were searched. Observational studies assessing ACT related major adverse cardiac event (MACE) and major bleeding were included.
View Article and Find Full Text PDFCurrently, there are no studies addressing the influence of age on the prognostic information of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in Asian population with acute coronary syndrome (ACS). The purpose of this study was to investigate the prognostic performance of NT-proBNP in Chinese patients with ACS across different age groups. A total of 1512 ACS patients with venous blood NT-proBNP measured were enrolled.
View Article and Find Full Text PDFBackground: Whether body composition is associated with the N-terminal pro-B-type natriuretic peptide (NT-proBNP) level and its prognostic performance in acute coronary syndrome (ACS) remains unknown. We aimed to investigate the influence of body composition on the NT-proBNP level and its prognostic performance among ACS patients.
Methods: In total, 1623 ACS patients with NT-proBNP data were enrolled.