Publications by authors named "Xiao-Bo Lu"

Article Synopsis
  • Acute-on-chronic liver disease (AoCLD) is a major cause of hospitalization in hepatology, prompting a study to better understand its characteristics for diagnosis and prognosis.
  • A total of 3,375 patients were analyzed, highlighting that liver cirrhosis acute decompensation (LC-AD) is the most common type, with hepatitis B virus (HBV) being the leading cause of chronic liver disease.
  • The study revealed high mortality rates associated with AoCLD subtypes, emphasizing that bacterial infections are significant precipitating factors and that timely medical intervention is crucial for improving patient outcomes.
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Background: Acute decompensation (AD) of cirrhosis is associated with high short-term mortality, mainly due to the development of acute-on-chronic liver failure (ACLF). Thus, there is a need for biomarkers for early and accurate identification of AD patients with high risk of development of ACLF and mortality. Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is released from activated innate immune cells and correlated with various inflammatory processes.

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The synergistic control of PM and ozone (O) are the focus of air quality improvement during the 14 Five-Year Plan in China. The production of O shows a highly nonlinear relationship with its precursors volatile organic compounds (VOCs) and nitrogen oxides (NO). In this study, we conducted online observations of O, VOCs, and NO at an urban site in downtown Nanjing from April to September of 2020 and 2021.

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Article Synopsis
  • Emerging zoonoses from wildlife, like the plateau pika virus (PPV), pose significant threats to human health, especially in unique ecosystems like the Qinghai-Tibet Plateau.
  • Researchers identified PPV through virome analysis and found that it can replicate in various mammalian cells, causing serious health issues in animal models, including trembling and sudden death.
  • PPV is distinct from other known mammarenaviruses, with an estimated divergence time of 77-88 million years, indicating its long-standing presence before other similar viruses.
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Objectives: To investigate the relationship between systemic inflammatory response and short-term mortality in patients with non-cirrhotic chronic severe hepatitis (CSH) by using several indicators of inflammation including neutrophil-to-lymphocyte ratio (NLR), neutrophil (NEU), white blood cell (WBC), platelet-to lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR).

Methods: Data were collected from two prospectively enrolled CATCH-LIFE noncirrhotic cohorts. Cox regression analysis was used to investigate the association between systemic inflammatory biomarkers and 90-day liver transplant (LT)-free mortality.

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Article Synopsis
  • Autoimmune liver disease (AILD) has been found to have a prevalence of 9.3% among cirrhotic patients in China suffering from acute decompensation (AD), based on a study of nearly 2,600 patients.
  • The study revealed that patients with AILD experienced a significantly lower rate of acute-on-chronic liver failure (ACLF) compared to those with cirrhosis from other causes, with 28-day and 90-day mortality rates in AILD-related ACLF patients being 43.8% and 80%, respectively.
  • Key risk factors for increased mortality within 90 days included total bilirubin levels, hepatic encephalopathy, and blood urea nitrogen, while the specific type of
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Background: In the treatment of transverse olecranon fractures, complicated tension band wiring (TBW) has high rates of re-operations. Besides, plate fixation (PF) and TBW both have large surgical incisions and soft-tissue irritation. Therefore, the new cross-locking intramedullary nail (CIN) with easy handling and minimally invasive features is significantly advantageous.

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Hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) is a complicated syndrome with extremely high short-term mortality. Whether plasma exchange (PE) improves HBV-ACLF outcomes remains controversial. Here, PE-based non-bioartificial liver support system (NB-ALSS) effects on short-term HBV-ACLF patient outcomes were investigated.

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In this study, the 24-hour backward trajectories of air mass at ground level(10 m)in Nanjing were calculated by using the HYSPLIT model with the NCEP global reanalysis data from April 1st to October 31st, 2017. The backward trajectories were then combined with the hourly concentration data of O in Nanjing for trajectories clustering analysis and potential pollution sources analysis. The results show that in 2017, the maximum daily 8 h running average O level in Nanjing was around 12-261 μg·m with 58 days of O pollution in Nanjing, mainly in the spring and summer.

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Article Synopsis
  • Portal vein thrombosis (PVT) is a serious issue in cirrhosis patients and is more common in those experiencing acute decompensation (AD), with a prevalence of 9.36% compared to 5.24% in those without AD.
  • Recent PVT was found in 63.37% of patients with cirrhosis and AD, and these patients also had higher rates of variceal bleeding and elevated D-dimer levels.
  • Despite the higher incidence of bleeding and complications, the one-year mortality rate was similar between patients with and without PVT, highlighting the need for preventive measures and regular screenings in vulnerable cirrhosis patients.
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In this paper, we present a novel high-frequency facial feature and a high-frequency based sparse representation classification to tackle single sample face recognition (SSFR) under varying illumination. Firstly, we propose the assumption that QRCP bases can represent intrinsic face surface features with different frequencies, and their corresponding energy coefficients describe illumination intensities. Based on this assumption, we take QRCP bases with corresponding weighting coefficients (i.

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Article Synopsis
  • Definitions of acute-on-chronic liver failure (ACLF) differ between Western and Eastern perspectives, with alcoholism and hepatitis B virus (HBV) being the primary causes in their respective regions.
  • A multicenter study in Asia is proposed to establish unified diagnostic criteria and treatment plans for ACLF, given the high prevalence of HBV in the region.
  • The study aims to enroll 2,600 patients from 14 liver centers in China, tracking data and outcomes over a 36-month period for those with chronic liver disease and acute complications.
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Purpose: Regenerative medicine provides many treatments for burn wounds, of which cell-seeded substitutes are encouraging for large and deep burns. To assess the feasibility of mesenchymal stem cell (MSC)-seeded small intestinal submucosa (SIS) to repair the deep partial-thickness burns, a rat study was performed.

Materials & Methods: The burn model was created by contacting the dorsal surface directly with boiled water for 10 seconds.

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Objective: To investigate the impacts of perioperative blood transfusion on the immune function and prognosis in colorectal cancer (CC) patients.

Methods: A retrospective analysis was conducted in 1404 CC patients, including 1223 sporadic colorectal cancer (SCC) patients and 181 hereditary colorectal cancer (HCC) patients. Among them, 701 SCC and 102 HCC patients received perioperative blood transfusion.

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We investigated the effects of perioperative blood transfusion in the prognosis of hereditary and sporadic colon cancer. There are 1075 colon cancer patients, including 936 sporadic colon cancer and 139 with hereditary colon cancer undergoing surgery at our hospital. All patients underwent 10 years of follow-up.

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The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at http://www.

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Objective: To explore the effectiveness and safety of transcutaneous electrical acupoint stimulation (TEAS) combined with infusion of propofol in anodynia bronchoscopy.

Methods: Ninety patients who received selective bronchoscopy were randomized into a group of compound TEAS with infusion of propofol (group A), a group of compound fentanyl with propofol (group B) and a group of simple propofol (group C). In group A, the plaster electrode stimulation was applied at bilateral Hegu (LI 4), Laogong (PC 8), Neiguan (PC 6) and Waiguan (TE 5).

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Objective: This meta-analysis was performed to evaluate the role of toll-like receptor 4 (TLR-4) in colorectal carcinogenesis.

Methods: The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched from inception through November 1st, 2013 without language restrictions. Odds ratios (ORs) or standardized mean differences (SMD) with their 95% confidence intervals (CI) were calculated.

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The aim of the present study was to determine whether allogeneic red blood cell transfusions showed a deleterious effect and what might be preoperative risk factors for blood transfusion in patients with TNM stage II colon cancer. Total 470 patients who fulfilled inclusion criteria were selected for a further 10-year follow-up study. We found that there were statistical significance between non-transfused and transfused group in mortality (P=0.

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Objective: To evaluate therapeutic and antioxidant effects of Uygur Herb Foeniculum Vulgare Mill (FVM) in hepatic fibrosis rats.

Method: Hepatic fibrosis model was built in rats by subcutaneous injection with 40% CCl4 olive oil mixture. At the same time the rats were given high lipoid-low protein animal feeds for 5 weeks.

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Objective: To investigate the effects of aluminum on learning and memory and the expression of N-methyl-D-aspartic acid receptor (NMDAR) of hippocampus in offspring from female rats exposed to Al in the pregnancy or lactation, and to explore the mechanism of toxic effects of Al on central nervous system (CNS) during development.

Methods: The pregnant Wistar rats were randomly divided into 3 groups based on their body weight, i.e.

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Objective: To explore characteristics of the myelin-like bodies in the hepatocytes of patients with Dubin-Johnson syndrome (DJS) complicated with chronic hepatitis B (CHB).

Methods: 11 cases of DJS complicated with CHB and 5 cases DJS without CHB were studied clinicopathologically. The hepatocyte ultrastructure was observed with transmission electron microscope and taken photos.

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Objective: To estimate the effect of aluminum on hippocampal intracellular Ca²+ concentration and expression of phospholipase C (PLC) and NMDA receptor α (NMDARα) genes in hippocampus as well as the neural behaviors in weaning rats through subchronic exposure in order to explore the mechanism which aluminum impaired the ability of learning and memory of central nervous system development.

Methods: Weaning Wistar rats were randomly divided into four groups based on their body weight. Aluminium chloride was administered by water at the doses of 0.

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