Publications by authors named "Xiao-Bo Chang"
Zhongguo Gu Shang
July 2020
Article Synopsis
- The study aimed to assess the short-term effectiveness of surgical treatment for ankle fractures with complete deltoid ligament tears in younger patients.
- A total of 21 patients underwent surgery, with follow-up showing successful healing and minimal complications, averaging 9.5 weeks for fracture recovery.
- Post-surgery evaluations indicated significant improvements in ankle function, with high AOFAS scores, suggesting that ligament repair alongside fracture fixation is beneficial for recovery.
Article Synopsis
- * The incorrect brand mentioned was Cell Signaling Technology, but it should have been Sigma-Aldrich.
- * The mistake was specifically related to the legend of Fig. 3, which detailed the antibody's handling conditions.
Article Synopsis
- Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious virus that affects pigs, and the study found that the protein annexin A2 (ANXA2) is increased in infected pig cells.
- Reducing ANXA2 expression significantly decreased PRRSV replication, indicating its role in the virus's life cycle.
- The research showed that ANXA2 interacts with vimentin, a protein related to cell structure, which is necessary for PRRSV growth, suggesting potential targets for future antiviral treatments.
Vet Microbiol
September 2017
Article Synopsis
- Porcine reproductive and respiratory syndrome (PRRS) has significantly impacted China's swine industry since its emergence in 1996, leading to substantial economic losses.
- A recent study sequenced and analyzed 217 PRRS virus strains, investigated available sequences from 1996-2016, and identified five lineages, with lineage 8 being the most prevalent.
- The research provides a detailed phylogeographical overview of PRRSVs in China, highlights the rise of lineage 1 and lineage 3 strains, and aims to enhance PRRS prevention strategies based on the findings.
Front Microbiol
December 2016
Article Synopsis
- Bacterial artificial chromosomes (BACs) are used for editing large DNA virus genomes, like herpesviruses, but current methods are slow and can result in virus loss.
- A new approach using CRISPR/Cas9 allows for efficient gene insertion into the Pseudorabies virus genome, achieving a recombination efficiency of 86%, the highest reported so far.
- This improved method simplifies BAC construction and enhances the ability to manipulate large DNA viruses, potentially aiding future research and applications in virology.
Article Synopsis
- Pseudorabies virus (PRV), which causes Aujeszky's disease, has become a concern in China due to recent outbreaks of emergent pseudorabies.
- This study analyzed the complete genomic sequences of two PRV strains: an earlier Chinese strain (SC) and an emergent strain (HLJ8), revealing differences in evolution among strains from different regions.
- The research also identified a new recombination event where strain SC originated from a combination of an endemic Chinese strain and a Bartha-vaccine-like strain, enhancing knowledge of PRV's evolutionary dynamics.
Article Synopsis
- - A majority of the highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) strains in China originated from a significant outbreak in 2006.
- - A new variant of HP-PRRSV, identified between 2013 and 2014, came from North America and has a distinct genetic makeup, having mixed with previous HP-PRRSV strains in China.
- - This new variant shows high pathogenicity, which makes it crucial for the development of effective control measures and vaccines.
Article Synopsis
- Recent pseudorabies outbreaks in vaccinated farms in China prompted a study to analyze the genetic characteristics of local PRV strains, specifically HeN1 and JS.
- Comparison with other PRV genomes revealed significant sequence divergence, categorizing Chinese strains as genotype II, distinct from genotype I found in European and American strains.
- The study suggests that long-term independent evolution of these strains may explain the poor effectiveness of the Bartha vaccine in protecting against genotype II PRV infections in pigs.
Chin J Integr Med
February 2014
Article Synopsis
- The study aimed to analyze how different acupuncture parameters affect the treatment outcomes in a rat model with middle cerebral artery occlusion (MCAO).
- Methods included creating MCAO models and grouping rats into various control and acupuncture groups with specific treatment parameters.
- Results showed varying effectiveness among different acupuncture groups based on the parameters used, with certain parameters yielding exceptional or valid results in improving neurobehavioral scores and cerebral blood flow.
Chin J Integr Med
November 2013
Article Synopsis
- The study aimed to evaluate the effectiveness and specificity of acupuncture points in treating rats with a model of stroke induced by middle cerebral artery occlusion (MCAO).
- Researchers used a total of 60 groups of rats, applying different acupuncture points and techniques, and assessed various health indicators like behavioral scores and blood flow.
- Results showed that the Neiguan acupuncture point yielded the best therapeutic effects, followed by Weizhong and Sanyinjiao, while non-acupoint treatments had no significant impact.
J Tradit Chin Med
March 2012
Article Synopsis
- The study aimed to evaluate the effectiveness of acupuncture on movement function recovery in rats suffering from middle cerebral artery occlusion (MCAO).
- A total of 1,384 rats were divided into various groups, including both control and acupuncture groups, and the acupuncture treatment was administered over six sessions while measuring neurobehavioral scores.
- Results showed that neurobehavioral scores increased significantly after acupuncture, particularly stabilizing after the fourth session, indicating that acupuncture effectively improves movement function in rats with cerebral infarction.
