Identification of new NIK inhibitors by discriminatory analysis-based molecular docking and biological evaluation.

NF-κB inducing kinase (NIK) is a key regulator in the noncanonical nuclear factor κB cells (NF-κB) signaling pathway. Dysregulation of NIK is often related with autoimmune disorders and malignancies. However, the number of reported NIK inhibitors is scarce.

[Determination of imperatorin in tetraploidy radix Angelicae dahuricae].

Objective: To determine the content of imperatorin in the tetraploidy radix angelicae dahuricae, and compare it with the original diplontic varites.

Method: The chromatographic method was carried out on Nova-pak (4.6 mm x 200 mm, 5 microns) column with acetonitrile-water solution as a mobile phase.