Publications by authors named "Xiao-Bing Ma"
Guchang Zhixie Wan (GZW) is a commonly used Chinese medicine for the treatment of ulcerative colitis (UC). This research explored the potential pharmacological mechanism of GZW in UC. The active ingredients, potential targets, and UC-related genes of GZW were retrieved from public databases.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates using adipose-derived stem cells (ADSCs) alongside chondrocytes to improve cartilage tissue engineering for craniofacial defects.
- It evaluates how these cells grow and differentiate when co-cultured with transforming growth factor-beta (TGF-β3) compared to being cultured alone.
- Results show that co-culturing ADSCs with chondrocytes promotes better cell growth and cartilage formation, indicating potential for improved cartilage repair strategies.
[Factors affecting the safety and efficacy of peroral endoscopic myotomy for achalasia].
Nan Fang Yi Ke Da Xue Xue Bao
June 2016
Article Synopsis
- The study aimed to assess factors influencing the safety and effectiveness of peroral endoscopic myotomy (POEM) for treating achalasia, analyzing data from 439 patients treated between December 2010 and December 2015.
- Of the patients, a complication rate of 28.7% was noted, with a high treatment success rate of 94.5%, showing significant improvement in symptoms post-procedure.
- Key findings include that the timing of the procedure and the type of entry incision significantly impact complication rates, with the inverted T incision being the safest option and full-thickness myotomy showing no recurrence of symptoms.
Objective: To study the medicinal plant resources and their diversity in Kangle County, Gansu Province, and to provide scientific basis on utilization and protection of the medicinal plant resources of the county.
Methods: By field survey, sample collection, taxonomic identification and data verification methods.
Results: There were 258 species, 65 families in existing medicinal plants, of which 43 species, 39 genera and 24 families were national protection medicinal plants.
[Screen and validation of differentially expressing genes related to silicotic pulmonary fibrosis in rats].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
January 2012
Objective: To screen the differentially expressing genes between silicotic lung tissue and normal lung tissue, to identify the differentially expressing genes of matrix metalloproteinase-12 (MMP-12) and Cathepsin E and to explore the roles of those genes in silicosis development.
Methods: Thirty male SD rats were divided randomly into two groups: control group (6 rats) and exposure group (24 rats) which was exposed to SiO2 by intra-tracheal perfusion. On the 30 th, 60 th and 90 th days after exposure, 8 rats in model group and 2 rats in control group were executed and the lung tissues were obtained.
[Suppression subtractive hybridization technique and its applications in pulmonary fibrosis].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
April 2011
[Effects of silicotic alveolar macrophages exposed to SiO2 on the expression of type III collagen and type III procollagen in human lung fibroblasts].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
April 2011
Article Synopsis
- The study investigates how the supernatant from silicotic alveolar macrophages exposed to silica (SiO2) affects the expression of type III collagen and type III procollagen in human lung fibroblasts (HELF).
- The experiment involved comparing HELF responses to supernatants from macrophages exposed to SiO2 versus controls, and included groups treated with an anti-TGF-beta1 antibody to assess its intervention effects.
- Results showed significantly higher levels of both procollagen (pC III) and collagen (C III) in the exposure group compared to the controls, indicating that SiO2 exposure influences fibroblast collagen expression.
[Effect of silica on expression of interleukin-1β of lung alveolus macrophages in patients with silicosis].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
November 2010
[Effect of human silicotic alveolar macrophages on expression of matrix metalloproteinase, tissue inhibitor of metalloproteinase and collagen in human lung fibroblasts].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
July 2009
Objective: To study the effect of culture supernatant of alveolar macrophage alveolar macrophages (AM) stimulated by SiO2 on the expression of matrix metalloproteinases (MMP-1), tissue inhibitor of metalloproteinase-1 (TIMP-1) and collagen of fibroblast human embryonic lung fibroblasts (HELF) in the development of silicosis fibrosis.
Methods: AMs were collected from a silicotic patient by bronchoalveolar lavage and exposed to SiO2, cultured human embryo lung fibroblast were allocated into a treated group, a control group, a positive group, and a blank group. HELF was incubated with the cultured supernatant of AMs for 6, 12, 18, 24, 36, 48 h.
[Effect of SiO(2) on expression of platelet derived growth factor in human silicotic alveolar macrophages and human embryonic lung fibroblasts].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
April 2009
Article Synopsis
- - The study aimed to investigate how SiO(2) influences the expression of platelet derived growth factor (PDGF) in human alveolar macrophages (AM) and embryonic lung fibroblasts (HELF).
- - Researchers collected AM from a silicotic patient and exposed them to SiO(2) for various durations, then analyzed the PDGF expression in both AM and HELF through various biochemical methods, finding significant increases over time.
- - Results indicated that SiO(2) exposure enhances PDGF expression and collagen synthesis, suggesting a role in the development of lung fibrosis mediated by AM.
[Construction and primary identification of a naive Fab fragment phage library].
Wei Sheng Yan Jiu
March 2006
Objective: To construct a naive human Fab fragment phage display library, provide a platform for human antibody preparation and a new therapy for the malignant tumors.
Methods: Peripheral blood lymphocytes were isolated from 200 ml blood, which was obtained from a healthy blood donor. The heavy chain Fd fragments and light chain cDNA synthesized from the total RNA of lymphocytes were amplified by PCR and the amplification products were ligated into the phagemid vector pComb3, then the ligated sample was transformed into competent E.
[Effect of SiO2 on the expression of MMP-9 and TIMP-1 in human alveolar macrophages in vitro].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
June 2005
Objective: To study the effect of SiO(2) on the expression of matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) in human alveolar macrophages (AMs) associated with the pathogenesis of silicotic fibrosis.
Methods: AMs were collected from a silicotic patient by bronchoalveolar lavage, and exposed to SiO(2) (50 microg/ml), and cultured in DMEM without serum for different time (2, 6, 12, 18, 24, 36 h). Immunocytochemical method was used to detect the level of expression of MMP-9 and TIMP-1 in AMs.
[Effect of human silicotic alveolar macrophages on the expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases-1 in human lung fibroblasts].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
October 2004
Objective: To study the effect of the cultured supernatant of human silicotic alveolar macrophages (AM) on the expression of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in human lung fibroblasts (FB).
Methods: Human alveolar macrophages were collected from a silicotic patients by bronchoalveolar lavage and exposed to SiO(2), then the cultured supernatant were incubated with human fetal lung fibroblasts for 6, 12, 18, 24, 36, 48 h. The immunocytochemical method was used to detect the level of expression of MMP-1 and TIMP-1 in lung fibroblasts.