Publications by authors named "Xiao-Bing Guan"
Article Synopsis
- Zeng-Sheng-Ping (ZSP) tablets, made from six Chinese herbs, are commonly used to help prevent and treat early-stage gastrointestinal cancer, but have been linked to occasional liver damage.
- A study analyzed the serum of hamsters experiencing ZSP-induced liver injury using NMR-based metabolomics, identifying twelve metabolites related to this hepatotoxicity and noting significant changes in amino acid metabolism and the urea cycle.
- The research also highlighted three specific amino acid enzymes as potential biomarkers for liver injury, while suggesting that certain compounds in two of the herbs may be responsible for the toxicity, leading to recommendations for a safer formulation of ZSP tablets.
[Diagnostic accuracy of MALDI-TOF mass spectrum in identification of oral Candidiasis isolates].
Shanghai Kou Qiang Yi Xue
December 2020
Purpose: To investigate the diagnostic accuracy of matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) in the identification of clinical oral Candida isolates.
Methods: In the first experiment, 170 suspected oral candidiasis patients were included. Unstimulated saliva was collected and cultured on solid plate (Sabouraud's agar) for 48 hours.
Background: Zengshengping (ZSP) tablets had inhibitory effects on oral precancerous lesions by reducing the incidence of oral cancer. However, the severe liver toxicity caused by systemic administration of ZSP limits the long-term use of this anti-cancer drug. The purpose of this study was to evaluate the tumor inhibitory effects due to the topical application of extracts from ZSP, a Chinese herbal drug, on 7, 12-dimethlbenz(a)anthracene (DMBA) induced oral tumors in hamsters.
View Article and Find Full Text PDF[Analysis of risk factors for carcinogenesis of oral leukoplakia].
Zhonghua Kou Qiang Yi Xue Za Zhi
June 2009
Objective: To investigate the risk factors for malignant transformation of oral leukoplakia.
Methods: A total of 409 cases with oral leukoplakia was retrospectively analyzed. Single factor test was first performed to examine the associations between oral leukoplakia's histopathological classification and each of risk factors including sex, age, systemic diseases, course of disease, clinical classification, site, size, numbers of lesion, alcohol and tobacco consumption, and symptom.