Publications by authors named "Xiao-Bin An"
Article Synopsis
- * Researchers used various methods, including gene manipulation with miR-195 and assays like immunofluorescence and flow cytometry, to evaluate microglial activation and polarization in the hippocampus over an 8-week period.
- * Findings indicated that CCCI leads to a shift in microglial polarization towards the M1 pro-inflammatory phenotype, with increased levels of CX3CL1 and CX3CR1, which are key signaling molecules involved in neuron-microglia communication.
Background: Chronic brain hypoperfusion (CBH) is closely related to Alzheimer's disease (AD) and vascular dementia (VaD). Meanwhile, synaptic pathology plays a prominent role in the initial stage of AD and VaD. However, whether and how CBH impairs presynaptic plasticity is currently unclear.
View Article and Find Full Text PDFWhether blood amyloid-β (Aβ) could be a peripheral biomarker of Alzheimer's disease (AD) remains in dispute. In the present study, we conducted a meta-analysis with 19 citations searched from Embase, PubMed, and the Cochrane Library database. Weighted mean difference (WMD) with 95% confidence intervals (CIs) was used to estimate the effect size.
View Article and Find Full Text PDF