Therapeutic potential of monomethyl fumarate and aluminum ion combination in alleviating inflammation and oxidative stress in psoriasis.

Psoriasis is a chronic inflammatory skin condition characterized by erythematous plaques with white scales. Its pathogenesis is closely linked to oxidative stress and an imbalance in Th1/Th2 immune responses. Current treatments for psoriasis, such as topical agents, systemic therapies and phototherapy, frequently fail to achieve complete remission in clinical settings.

Response of ZmPHO1 family members to low phosphorus stress and association of natural variation in ZmPHO1;2a reveal the role of low phosphorus tolerance.

Phosphorus (Pi) is an essential nutrient for plants to sustain normal life processes. In this study, we found that the ZmPHO1 proteins had similar molecular weights and the same conserved domain. Phylogenetic and cis-acting element analysis showed that ZmPHO1s were divided into 4 subgroups, in which ZmPHO1;2a and ZmPHO1;2b were closely phylogenetic with OsPHO1;2b, and the promoter region of ZmPHO1s contained abundant abiotic stress-related elements.

Mitochondrial transplantation reconstructs the oxidative microenvironment within fibroblasts to reverse photoaging.

Fibroblast-mediated oxidative stress is a pivotal factor in the pathogenesis of skin photoaging, predominantly induced by UVA radiation. Diverging from traditional strategies that concentrate on the reduction of reactive oxygen species (ROS), the present study implements mitochondrial transplantation as an innovative therapeutic approach. The objective of this study is to reestablish the oxidative microenvironment and to effectively rejuvenate cellular functionality through the direct introduction of healthy and vibrant mitochondria.

Transplantation of derivative retinal organoids from chemically induced pluripotent stem cells restored visual function.

As an emerging type of pluripotent stem cells, chemically induced pluripotent stem cells (CiPSCs) avoid the risks of genomic disintegration by exogenous DNAs from viruses or plasmids, providing a safer stem cell source. To verify CiPSCs' capacity to differentiate into retinal organoids (ROs), we induced CiPSCs from mouse embryonic fibroblasts by defined small-molecule compounds and successfully differentiated the CiPSCs into three-dimensional ROs, in which all major retinal cell types and retinal genes were in concordance with those in vivo. We transplanted retinal photoreceptors from ROs into the subretinal space of retinal degeneration mouse models and the cells could integrate into the host retina, establish synaptic connections, and significantly improve the visual functions of the murine models.

Differential alterations of structural network in temporal lobe epilepsy with different seizure types are associated with cognitive and psychiatric status.

Background: The fundamental pathophysiologic understanding of different seizure types in Temporal lobe epilepsy (TLE) remains unclear. This study aimed to assess the distinct alterations of structural network in TLE patients with different seizure types and their relationships with cognitive and psychiatric symptoms.

Methods: Seventy-three patients with unilateral TLE, including 25 with uncontrolled focal to bilateral tonic-clonic seizures (FBTCS), 25 with controlled FBTCS and 23 with focal impaired awareness seizures (FIAS), as well as 26 healthy controls (HC), underwent the diffusion tensor imaging (DTI) scan.

TFEB Phase Separation Mediates the Amelioration Effect of Intermittent Fasting on Inflammatory Colitis.

Intermittent fasting (IF) has been shown to ameliorate inflammation including DSS-induced colitis. It is well known that autophagy can limit inflammation and TFEB is a master transcriptional factor that regulates the processes of autophagy. However, whether TFEB is involved in the regulation of IF-mediated amelioration of inflammation and its mechanism remained unclear.

[Comprehensive evaluation of resistance to Cd stress in mycorrhizal seedlings formed by different genotypes of and ].

To select the mycorrhizal seedlings of with excellent Cd-resistance and explore the mechanism of promoting the resistance to Cd stress of , nine species of isolated from different hosts infected to form mycorrhizal seedlings, were cultured in Cd-contaminated soil for three months. We conducted the principal component analysis (PCA) on biomass, root structure, and photosynthesis, and evaluated the Cd tolerance of mycorrhizal seedlings by membership function. The results showed that dry and fresh weight of mycorrhizal seedlings under Cd stress were 1.

Besides traditional organophosphate esters: The ecological risks of emerging organophosphate esters in the Yangtze River basin cannot be ignored.

In addition to traditional organophosphate esters (tOPEs), emerging organophosphate esters (eOPEs) have increasingly been detected in the environment, but their risks remain unclear. This study detected 12 tOPEs and 7 eOPEs in surface water, sediment, and suspended particulate matter (SPM) samples from important aquatic habitats and drinking water sources in Yibin (YB), Yichang (YC), Shanghai (SH), and Poyang Lake (PY) within the Yangtze River basin. The total concentration of OPEs (ΣOPEs) in surface water, sediment, and SPM from these four regions were 22.

Bayesian analysis of multivariate mixed longitudinal ordinal and continuous data.

Multivariate longitudinal ordinal and continuous data exist in many scientific fields. However, it is a rigorous task to jointly analyse them due to the complicated correlated structures of those mixed data and the lack of a multivariate distribution. The multivariate probit model, assuming there is a multivariate normal latent variable for each multivariate ordinal data, becomes a natural modeling choice for longitudinal ordinal data especially for jointly analysing with longitudinal continuous data.

Molecular identification of tick (Acari: Ixodidae) and tick-borne pathogens from Przewalski's gazelle (Procapra Przewalskii) and Tibetan sheep (Ovis aries) in Qinghai Lake National Nature Reserve, China.

The Qinghai Lake National Nature Reserve (QLNNR), renowned for its abundant natural resources and diverse ecological habitats, serves as an ideal environment for ticks, thereby increasing the risk of various tick-borne pathogens (TBPs) transmission. This study aimed to investigate the prevalence of TBPs in ticks collected from Przewalski's gazelle and Tibetan sheep within the QLNNR. A total of 313 tick samples were collected from the vicinity of Qinghai Lake.

Crosslinking-Driven Chemical Homogeneity Enhances Performance of Pre-Seeded Perovskite Solar Cells.

Perovskite solar cells (PSCs) have achieved impressive efficiency, but their commercialization is limited by issues like chemical homogeneity within the perovskite films, leading to defects and phase segregation, which severely compromise the stability and performance of PSCs. This study presents a novel approach to overcoming these barriers by employing N,N-methylenebisacrylamide (MBA) as a multifunctional crosslinking agent within the perovskite structure. MBA enhances chemical uniformity both laterally and vertically, improves crystallinity, and boosts overall film stability by forming a robust crosslinked network that regulates nucleation and growth dynamics during the pre-seeding process.

Molecular intersections of traumatic brain injury and Alzheimer's disease: the role of ADMSC-derived exosomes and hub genes in microglial polarization.

Traumatic brain injury (TBI) is a significant contributor to global mortality and morbidity, with emerging evidence indicating a heightened risk of developing Alzheimer's disease (AD) following TBI. This study aimed to explore the molecular intersections between TBI and AD, focusing on the role of adipose mesenchymal stem cell (ADMSC)-derived exosomes and hub genes involved in microglial polarization. Transcriptome profiles from TBI (GSE58485) and AD (GSE74614) datasets were analyzed to identify differentially expressed genes (DEGs).

Decreased Secondary Electron Emission from Aluminum Surface by a Fluorocarbon-Titanium Composite Film.

Multipactor, a vacuum discharge under microwave conditions triggered by secondary electron emission (SEE), plays a critical role in managing the power level of microwave devices. In this study, we developed a fluorocarbon-titanium composite film on aluminum by cosputtering polytetrafluoroethylene (PTFE) and titanium via a controlled temperature and sputtering power ratio (RF power for PTFE to DC power for Ti) to suppress the SEE of Al. The evolution of microtopography and chemical composition of the composite film was evaluated.

Evaluation of the toxoplasma Urm1 gene deletion mutant (PruΔUrm1) as a promising vaccine candidate against toxoplasmosis in mice.

Toxoplasmosis is a significant zoonotic disease that poses a serious threat to both human and animal health. Despite ongoing research, developing an effective vaccine for toxoplasmosis remains a challenge. In this study, we evaluated the vaccine potential of the Toxoplasma Urm1 gene deletion mutant (PruΔUrm1) by assessing its pathogenicity and protective efficacy in mice.

Case report: CAR-T therapy demonstrated safety and efficacy in relapsed/refractory diffuse large B-cell lymphoma patients complicated with hepatitis B-related cirrhosis.

Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated both efficacy and safety in relapsed/refractory diffuse large B-cell lymphoma (DLBCL) patients infected with hepatitis B virus (HBV). However, its applicability in individuals with liver cirrhosis remains largely unexplored due to the potential for unpredictable complications. Here, we report three cases (P1, P2, and P3) of relapsed/refractory DLBCL with HBV-related cirrhosis treated with CAR-T cell infusion.

[Genome-wide identification of Atropa belladonna WRKY transcription factor gene family and analysis of expression patterns under light and temperature regulation].

Based on whole genome data, the identification and expression pattern analysis of the Atropa belladonna WRKY transcription factor family were conducted to provide a theoretical foundation for studying the biological functions and mechanisms of these transcription factors. In this study, bioinformatics methods were employed to identify members of the A. belladonna WRKY gene family and to predict their physicochemical properties, conserved motifs, promoter cis-acting elements, and chromosomal localization.

Comprehensive analysis of the stress associated protein (SAP) family and the function of PagSAP9 from Populus alba × P. glandulosa in salt stress.

Poplar tree growth is frequently hindered by environmental stressors, particularly soil salinization. Enhancing salt tolerance is essential for improving their adaptability and biomass under these conditions. The Stress-Associated Protein (SAP) family, characterized by A20/AN1 zinc finger domains, plays a crucial role in plants' tolerance to abiotic stress.

Assessing vegetation dynamics and human impacts in natural and urban areas of China: Insights from remote sensing data.

Vegetation changes and human activities in both natural and urban environments have played a crucial role in carbon cycling and sustainable development globally. However, there is an insufficient comparison in national vegetation changes across regions with varying intensities of human activities to those natural areas. Based on urban boundary and night-time light datasets, we have identified and extracted rural, urban-low activity, and urban-high activity areas within China.

Myeloid response evaluated by noninvasive CT imaging predicts post-surgical survival and immune checkpoint therapy benefits in patients with hepatocellular carcinoma.

Background: The potential of preoperative CT in the assessment of myeloid immune response and its application in predicting prognosis and immune-checkpoint therapy outcomes in hepatocellular carcinoma (HCC) has not been explored.

Methods: A total of 165 patients with pathological slides and multi-phase CT images were included to develop a radiomics signature for predicting the imaging-based myeloid response score (iMRS). Overall survival (OS) and recurrence-free survival (RFS) were assessed according to the iMRS risk group and validated in a surgical resection cohort ( = 98).

Recent Advances in Gene Mining and Hormonal Mechanism for Brown Planthopper Resistance in Rice.

Rice ( L.) feeds half the world's population and serves as one of the most vital staple food crops globally. The brown planthopper (BPH, Stål), a major piercing-sucking herbivore specific to rice, accounts for large yield losses annually in rice-growing areas.

Oral Targeted Delivery of Codonopsis Radix Polysaccharide via Succinyl -DHA Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis.

Introduction: Ulcerative colitis (UC) is a chronic intestinal disease characterized by spleen-lung qi deficiency and dampness-pathogenic obstruction. Although there are various treatment options available, patients frequently encounter significant drug-related side effects. Previous studies have shown the potential of A (CPA) in treating UC, but their limited bioavailability has restricted their clinical use.

Study of TRAF3IP3 for prognosis and immune infiltration in hepatocellular carcinoma.

Background: Tumor necrosis factor receptor-associated factor 3 (TRAF3)-interacting protein 3 (TRAF3IP3) expressed in various tumor cell. However, its role in hepatocellular carcinoma (HCC) was unclear. We aimed to demonstrate the relationship between TRAF3IP3 and HCC and explore the potential role of TRAF3IP3 in HCC.

Sec24C Participates in Cuticular Wax Transport by Facilitating Plasma Membrane Localization of ABCG5.

Cuticular waxes synthesised in the endoplasmic reticulum of epidermal cells must be exported to the outer surface of the epidermis to fulfil their barrier function. Beyond transmembrane trafficking mediated by ABC transporters, little is known about the movement of wax molecules. In this study, we characterise a mutant named sugar-associated vitrified 1 (sav1), which exhibits a vitrified phenotype and displays a reduced root length when cultivated on sugar-free medium.

Dental Caries and Associated Factors in Tibetan School-Age Children in Gannan, China.

Objectives: Data on the oral health status in the Qinghai-Tibetan Plateau are limited. This study aimed to investigate the dental caries status and identify associated risk factors among 8- to 12-year-old children in Gannan, a Tibetan Autonomous Prefecture in Northwest China.

Methods: The study population was recruited using a multistage stratified random sampling procedure.

Optic disc changes in Chinese patients with -associated autoinflammatory disease.

Objective: To investigate the optic disc changes (ODC) in Chinese patients with -associated autoinflammatory disease (-AID).

Methods: Patients who were diagnosed with -AID at the Department of Rheumatology, Peking Union Medical College Hospital between April 2015 and December 2022 were retrospectively reviewed and analyzed.

Results: A total of 20 patients were enrolled in this retrospective study.