Engineered Luminescent Oncolytic Vaccinia Virus Activation of Photodynamic-Immune Combination Therapy for Colorectal Cancer.

Oncolytic virus therapy is currently regarded as a promising approach in cancer immunotherapy. It has greater therapeutic advantages for colorectal cancer that is prone to distant metastasis. However, the therapeutic efficacy and clinical application of viral agents alone for colorectal cancer remain suboptimal.

Selective anchoring of Pt NPs on covalent triazine-based frameworks derived bridging ligands for boosting photocatalytic hydrogen evolution.

The efficient and stable production of hydrogen (H) through Pt-containing photocatalysts remains a great challenge. Herein, we develop an effective strategy to selectively and uniformly anchor Pt NPs (∼1.2 nm) on a covalent triazine-based framework photocatalyst derived bridging ligands.

Degradation of pesticide wastewater with simultaneous resource recovery via ozonation coupled with anaerobic biochemical technology.

The effective treatment of pesticide wastewater with high organic content, complex composition and high-toxicity has attracted enormous attention of researchers. This work proposes a new idea for removing the pesticide wastewater with simultaneous resource recovery, which is different from the traditional view of mineralization of pesticide wastewater via composite technology. This novel strategy involved a sequential three-step treatment: (a) acidic Ozonation process, to remove the venomous aromatic heterocyclic compounds; (b) hydrolysis and ozonation in alkaline conditions, enhancing the biodegradability of pesticide wastewater, mainly due to the dehalogenation, elimination of C=C bonds and production of low molecular-weight carboxylate anions; (c) the final step is anaerobic biological reactions.

Boundary Stabilization of Stochastic Delayed Cohen-Grossberg Neural Networks With Diffusion Terms.

This study considers the boundary stabilization for stochastic delayed Cohen-Grossberg neural networks (SDCGNNs) with diffusion terms by the Lyapunov functional method. In the realization of NNs, sometimes time delays and diffusion phenomenon cannot be ignored, so Cohen-Grossberg NNs with time delays and diffusion terms are studied in this article. Moreover, different from the previously distributed control, the boundary control is used to stabilize the system, which can reduce the spatial cost of the controller and is easy to implement.

Correlation between Genotype and Phenotype in 69 Chinese Patients with USH2A Mutations: A comparative study of the patients with Usher Syndrome and Nonsyndromic Retinitis Pigmentosa.

Purpose: The aim of this study was to analyse 69 Chinese patients with USH2A mutations and to assess the genotype-phenotype correlation.

Methods: All 36 Usher syndrome type IIA patients and 33 nonsyndromic RP (retinitis pigmentosa) patients underwent clinical examinations. Eye examinations included best-corrected visual acuity, slit-lamp biomicroscopy, fundus examination with dilated pupils, fundus fluorescent angiography, visual field test, full-field electroretinography and optic coherence tomography; audiological assessment included pure tone audiometry and hearing thresholds.

Boundary Mittag-Leffler stabilization of fractional reaction-diffusion cellular neural networks.

Mittag-Leffler stabilization is studied for fractional reaction-diffusion cellular neural networks (FRDCNNs) in this paper. Different from previous literature, the FRDCNNs in this paper are high-dimensional systems, and boundary control and observed-based boundary control are both used to make FRDCNNs achieve Mittag-Leffler stability. First, a state-dependent boundary controller is designed when system states are available.

Intermittent boundary stabilization of stochastic reaction-diffusion Cohen-Grossberg neural networks.

Cohen-Grossberg neural networks (CGNNs) play an important role in many applications and the stabilization of this system has been well studied. This study considers the exponential stabilization for stochastic reaction-diffusion Cohen-Grossberg neural networks (SRDCGNNs) by means of an aperiodically intermittent boundary control. Both SRDCGNNs without and with time-delays are discussed.

Simultaneous expression of two pathogenic genes in four Chinese patients affected with inherited retinal dystrophy.

Aim: To describe the complex, overlapping phenotype of four Chinese patients with inherited retinal dystrophies (IRDs) who harbored two pathogenic genes simultaneously.

Methods: This retrospective study included 4 patients affected with IRDs. Medical and ophthalmic histories were obtained, and clinical examinations were performed.

Effect of Lactobacillus plantarum NCU116 Fermentation on Asparagus officinalis Polysaccharide: Characterization, Antioxidative, and Immunoregulatory Activities.

Lactic acid fermentation represents a novel method to produce bioactive functional ingredients, including polysaccharides. In this work, a selected lactic acid bacteria strain NCU116 was used to ferment Asparagus officinalis (asparagus) pulps. Two polysaccharides were subsequently separated from both unprocessed and fermented asparagus pulps, namely, asparagus polysaccharide (AOP) and fermented-AOP (F-AOP).

Genetic screening and functional analysis of CASP9 mutations in a Chinese cohort with neural tube defects.

Aim: Neural tube defects (NTDs) are birth defects of the nervous system and are the second most frequent cause of birth defects worldwide. The etiology of NTDs is complicated and involves both genetic and environmental factors. CASP9 is an initiator caspase in the intrinsic apoptosis pathway, which in Casp9 mice has been shown to result in NTDs because of decreased apoptosis.

Arenimonas soli sp. nov., isolated from saline-alkaline soil.

A Gram-staining-negative, non-motile, aerobic bacterial strain, designated Y3L17T, was isolated from the saline-alkaline soil of a farmland, Hangjin Banner, Inner Mongolia, northern China. Y3L17T could grow at 15-45 °C (optimum 35 °C), pH 6.0-10.

Aliidiomarina soli sp. nov., isolated from saline-alkaline soil.

A Gram-stain-negative, motile, non-spore-forming bacterium, designated strain Y4G10-17T, was isolated from the saline-alkali farmland top soil, Inner Mongolia, northern China. Strain Y4G10-17T could grow at 4-45 °C (with 30 °C as the optimal temperature), pH 6.0-12.

[Preparation of La(2)Zr(2)O(7) Powder with Combustion Method and Its Spectral Properties].

La(2)Zr(2)O(7) powder was prepared with combustion method with La(2)O(3), Zr(NO(3))(4) and glycine as raw materials. La(2)Zr(2)O(7) powders were characterized with ICP-AES, EDAX, XRD, IR and TG-DTA techniques, respectively. Effects of heat treatment temperature on the XRD spectra and IR spectra of La(2)Zr(2)O(7) powders were studied.

Effect of REAu on Silver Staining Results and Their UV-Vis Absorption Spectra.

La, Ce, Nd, Sm, Eu, Gd, Dy particles and gold nanoparticles were prepared. Effects of La-Au, Ce-Au, Nd-Au, Sm-Au, Eu-Au, Gd-Au and Dy-Au particles on silver staining results were studied, respectively, and UV-Vis absorption spectra of La-Au, Ce-Au, Nd-Au, Sm-Au, Eu-Au, Gd-Au and Dy-Au particles were studied. Times and colors of sports with La-Au, Ce-Au, Nd-Au, Sm-Au, Eu-Au, Gd-Au, Dy-Au particles are longer and darker than that of with gold nanoparticles, respectively.

Reducing central serotonin in adulthood promotes hippocampal neurogenesis.

Chronic administration of selective serotonin reuptake inhibitors (SSRIs), which up-regulates central serotonin (5-HT) system function, enhances adult hippocampal neurogenesis. However, the relationship between central 5-HT system and adult neurogenesis has not fully been understood. Here, we report that lowering 5-HT level in adulthood is also able to enhance adult hippocampal neurogenesis.

Ganoderma atrum Polysaccharide Ameliorates Hyperglycemia-Induced Endothelial Cell Death via a Mitochondria-ROS Pathway.

The aim of the present study was to examine the role of Ganoderma atrum polysaccharide (PSG-1) in reactive oxygen species (ROS) generation and mitochondrial function in hyperglycemia-induced angiopathy. In this work, ROS scavenger, oxidizing agent tert-butylhydroperoxide (tBH), mitochondrial permeability transition pore (mPTP) blockers, and caspase inhibition are used to investigate whether PSG-1 may promote survival of human umbilical vein cells (HUVECs) through preventing the overproduction of ROS and mitochondrial dysfunction. Experimental results show that exposure of HUVECs to 35.

Effect of Heat Treatment Temperature on the Spectral Properties of Cu-Ni Coating.

Cu-Ni coatings were prepared on the surface of nickel by electrodeposition method, and Cu-Ni coatings were heat-treated in 25-900 °C. Heat-treated Cu-Ni coatings were characterized with scanning electron microscopy (SEM), energy dispersive x-ray analysis (EDAX) and X-ray diffraction (XRD) techniques, respectively. Effects of heat treatment temperature on the spectral properties of Cu-Ni coatings were studied.

Superovulation Induced Changes of Lipid Metabolism in Ovaries and Embryos and Its Probable Mechanism.

This research was intended to investigate the fetal origins of changed birth weight of the offspring born through assisted reproductive technology (ART). The association between hormone and lipid metabolism or body weight has been generally accepted, and as the basic and specific treatment in ART procedure, gonadotropin stimulation might have potential effects on intrauterine lipid metabolism. In our studies, the mice were superovulated with two doses of gonadotropin.

[Optimization of extraction process for tannins from Geranium orientali-tibeticum by supercritical CO2 method].

In order to optimize extraction process conditions of tannins from Geranium orientali-tibeticum by supercritical CO2, the content of tannins was determined by phosphomolybdium tungsten acid-casein reaction, with extraction pressure, extraction temper- ature and extraction time as factors, the content of tannins from extract of G. orientali-tibeticum as index, technology conditions were optimized by orthogonal test. Optimum technology conditions were as follows: extraction pressure was 25 MPa, extraction temperature was 50 °C, extracted 1.

[Association of folate metabolism genes MTRR and MTHFR with complex congenital abnormalities among Chinese population in Shanxi Province, China].

Objective: To explore the association of polymorphisms in folate metabolism genes, methionine synthase reductase (MTRR) gene and 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, with complex congenital abnormalities and to further investigate its association with complex congenital abnormalities derived from three germ layers.

Methods: A total of 250 cases of birth defects (with complex congenital abnormalities including congenital heart disease, neural tube defects, and craniofacial anomalies) in Shanxi Province, China were included in the study. MTRR single nucleotide polymorphism (SNP) (rs1801394) and MTHFR SNP (rs1801133) were genotyped by the SNaPshot method, and the genotyping results were compared with those of controls (n=420).

Preparation of electrodeposited Mo-Ni coating and its spectral properties.

Mo-Ni coatings were prepared on Ni alloy by electrodeposition method. The properties of microhardness, wear weight loss and friction coefficients, and thermal expansion of the coatings were investigated, respectively. Mo-Ni coatings were characterized with inductively coupled plasma-atomic emission spectroscopy (ICP-AES), energy-dispersive analyses of X-ray (EDAX), scanning electron microcopy (SEM), and X-ray diffraction (XRD) techniques, respectively.

Chemoprotective effects of Ganoderma atrum polysaccharide in cyclophosphamide-induced mice.

In this study, the chemoprotective effects of Ganoderma atrum polysaccharide (PSG-1) in cyclophosphamide (Cy) treated mice were investigated. In Cy-treated mice, PSG-1 treatment accelerated recovery dose-dependently of peripheral red blood cells, white blood cells and platelets, enhanced splenic natural killer cell activity and cytotoxic T lymphocyte activity. In addition, PSG-1 elevated CD4(+) T lymphocyte counts as well as the CD4(+)/CD8(+) ratio dose-dependently.

Epigenetic inheritance of paternally expressed imprinted genes in the testes of ICSI mice.

Worse reproductive health in the men born through intracytoplasmic sperm injection (ICSI) or other assisted reproductive techniques (ART) has been reported in many studies. However, owing to the interference of genetic and environmental factors, it is difficult to identify whether ICSI method would affect male reproductive health. Therefore, ART mouse models were established in this study.

Alterations in the frequency of trinucleotide repeat dynamic mutations in offspring conceived through assisted reproductive technology.

Study Question: How does the frequency of trinucleotide repeat dynamic mutations in offspring conceived through assisted reproductive technology (ART) compare with the frequency of these mutations in control offspring conceived from spontaneous pregnancies?

Summary Answer: There is a slight increase in dynamic mutation instability in offspring conceived through ART compared with the naturally conceived offspring.

What Is Known Already: There is evidence to suggest that ART can increase the risk of birth defects and karyotypic abnormalities. However, the accumulating evidence of an association between ART and de novo genetic aberrations is controversial.

Persistence and intergenerational transmission of differentially expressed genes in the testes of intracytoplasmic sperm injection conceived mice.

Intracytoplasmic sperm injection (ICSI) is commonly used to solve male infertility problems. Previous studies showed that early environmental exposure of an embryo may influence postnatal development. To detect whether ICSI operations affect the reproductive health of a male or his offspring, we established assisted reproductive technologies (ART) conceived mouse models, and analyzed gene expression profiles in the testes of both ICSI and naturally conceived (NC) newborn F1 mice using micro-array analysis.