N-Selective alkenylation of 1-sulfonyl-1,2,3-triazoles with alkynes via gold catalysis.

A N-selective alkenylation of 1-sulfonyl-1,2,3-triazoles with alkynes via gold catalysis is reported. N-Vinyl substituted 1,2,3-triazoles were selectively prepared in up to 92% yield through the sulfonyl group of 1,2,3-triazole derivatives transformed to alkenyl groups in a "one-pot two steps" manner. This method provided a new method for the synthesis of potentially biological-active vinyl-triazole building blocks.

Functional changes of neural circuits in stroke patients with dysphagia: A meta-analysis.

Objective: Dysphagia is a common problem in stroke patients with unclear pathogenesis. Several recent functional magnetic resonance imaging (fMRI) studies had been carried out to explore the cerebral functional changes in dysphagic stroke patients. The aim of this study was to analysis these imaging findings using a meta-analysis.

Gray matter abnormalities in pediatric autism spectrum disorder: a meta-analysis with signed differential mapping.

The gray matter abnormalities revealed by magnetic resonance imaging are inconsistent, especially in pediatric individuals with autism spectrum disorder (ASD) (age < 18 years old), a phenomenon possibly related to the core pathophysiology of ASD. The purpose of our meta-analysis was to identify and map the specific gray matter abnormalities in pediatric ASD individuals thereby exploring the potential effects of clinical and demographic characteristics of these gray matter changes. A systematic search was conducted to identify voxel-based morphometry studies in pediatric individuals with ASD.

Intercellular Tension Negatively Regulates Angiogenic Sprouting of Endothelial Tip Cells via Notch1-Dll4 Signaling.

Mechanical force plays pivotal roles in vascular development during tissue growth and regeneration. Nevertheless, the process by which mechanical force controls the vascular architecture remains poorly understood. Using a systems bioengineering approach, we show that intercellular tension negatively regulates tip cell formation via Notch1-Dll4 signaling in mouse retinal angiogenesis in vivo, sprouting embryoid bodies, and human endothelial cell networks .

Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients.

Gastric cancer is one of the most common cancers and the efficient therapeutic methods are limited. Further study of the exact molecular mechanism of gastric cancer to develop novel targeted therapies is necessary and urgent. We herein systematically examined that miR-204 suppressed both proliferation and metastasis of gastric cancer AGS cells.

Atomistic Origins of Surface Defects in CHNHPbBr Perovskite and Their Electronic Structures.

The inherent instability of CHNHPbX remains a major technical barrier for the industrial applications of perovskite materials. Recently, the most stable surface structures of CHNHPbX have been successfully characterized by using density functional theory (DFT) calculations together with the high-resolution scanning tunneling microscopy (STM) results. The two coexisting phases of the perovskite surfaces have been ascribed to the alternate orientation of the methylammonium (MA) cations.

Characterization of saliva microbiota's functional feature based on metagenomic sequencing.

Objective: Saliva, a mixture of exocrinally secretive fluids, amounts to ~1.5 L daily and harbors numerous microbial inhabitants. However, except the organismal structure of saliva microbiota, the functional profile of saliva microbiota remain elusive.

[Effects of nitrogen deposition on the concentration and spectral characteristics of dissolved organic matter in soil solution in a young Cunninghamia lanceolata plantation.].

To study the effects of nitrogen deposition on the concentration and spectral characteristics of dissolved organic matter (DOM) in the forest soil solution from the subtropical Cunninghamia lanceolata plantation, using negative pressure sampling method, the dynamics of DOM in soil solutions from 0-15 and 15-30 cm soil layer was monitored for two years and the spectroscopic features of DOM were analyzed. The results showed that nitrogen deposition significantly reduced the concentration of dissolved organic carbon (DOC), and increased the aromatic index (AI) and the humic index (HIX), but had no significant effect on dissolved organic nitrogen (DON) concentration in both soil layers. There was obvious seasonal variation in DOM concentration of the soil solution, which was prominently higher in summer and autumn than in spring and winter.

Preparation of a Thermally Light-Transmittance-Controllable Film from a Coexistent System of Polymer-Dispersed and Polymer-Stabilized Liquid Crystals.

Polymer-dispersed liquid crystal (PDLC) and polymer-stabilized liquid crystal (PSLC) systems are the two primary distinct systems in the field of liquid crystal (LC) technology, and they are differentiated by their unique microstructures. Here, we present a novel coexistent system of polymer-dispersed and polymer-stabilized liquid crystals (PD&SLCs), which forms a homeotropically aligned polymer network (HAPN) within the LC droplets after a microphase separation between the LC and polymer matrix and combines the advantages of both the PDLC and PSLC systems. Then, we prepare a novel thermally light-transmittance-controllable (TLTC) film from the PD&SLC system, where the transmittance can be reversibly changed through thermal control from a transparent to a light-scattering state.

Suppression of progressive growth of intensity modulations with slit spatial filter in a laser system.

The performance of a slit spatial filter composed of two astigmatic lenses and two orthogonal slits for suppressing progressive growth of intensity modulations in a laser system was studied. Power spectral density (PSD) is used to evaluate the beam performance in the frequency domain. The filtering characteristics, image relay, and beam expansion properties of the slit spatial filter are discussed and demonstrated.

[Corrigendum] Neutrophils in cancer development and progression: Roles, mechanisms, and implications (Review).

After the publication of the article, the authors noted that there was a wrong citation for reference 116. This might be caused by reference formating software during writing. The wrongly cited reference in the article: 116.

Altered brain network topology in left-behind children: A resting-state functional magnetic resonance imaging study.

Whether a lack of direct parental care affects brain function in children is an important question, particularly in developing countries where hundreds of millions of children are left behind when their parents migrate for economic or political reasons. In this study, we investigated changes in the topological architectures of brain functional networks in left-behind children (LBC). Resting-state functional magnetic resonance imaging data were obtained from 26 LBC and 21 children living within their nuclear family (non-LBC).

Chiral N,N'-Dioxide-Scandium(III) Complex-Catalyzed Asymmetric Friedel-Crafts Alkylation Reaction of ortho-Hydroxybenzyl Alcohols with C3-Substituted N-Protected Indoles.

The first Lewis acid catalyzed asymmetric Friedel-Crafts alkylation reaction of ortho-hydroxybenzyl alcohols with C3-substituted indoles is described. A chiral N,N'-dioxide Sc(OTf) complex served not only to promote formation of ortho-quinone methides (o-QMs) in situ but also induced the asymmetry of the reaction. This methodology enables a novel activation of ortho-hydroxybenzyl alcohols, thus affording the desired chiral diarylindol-2-ylmethanes in up to 99 % yield and 99 % ee.

Apoptosis Inducing Factor Is Involved in Stretch-Induced Apoptosis of Myoblast via a Caspase-9 Independent Pathway.

The apoptosis of myoblast in response to excessive cyclic stretch is crucial in adaptive construction of skeletal muscles in orthopedic functional therapy. Mitochondria signaling pathway is the central links in the execution of the intrinsic apoptotic cascade, but its molecular mechanism in stretch-induced apoptosis in myoblasts remains incompletely understood. The aim of this study was to investigate the mechanobiological roles of caspase-9 and Apoptosis Inducing Factor (AIF), two important components in mitochondrial pathway, in stretch-induced apoptosis of myoblast.

Exosomes derived from gastric cancer cells activate NF-κB pathway in macrophages to promote cancer progression.

Exosomes are nano-sized membrane vesicles secreted by both normal and cancer cells. Emerging evidence indicates that cancer cells derived exosomes contribute to cancer progression through the modulation of tumor microenvironment. However, the effects of exosomes derived from gastric cancer cells on macrophages are not well understood.

FEATURES OF OPTICAL COHERENCE TOMOGRAPHY FOR THE DIAGNOSIS OF VOGT-KOYANAGI-HARADA DISEASE.

Background/purpose: To examine the diagnostic value of optical coherence tomography (OCT) for the detection of acute Vogt-Koyanagi-Harada (VKH) disease.

Methods: Clinical charts and OCT images were retrospectively reviewed for patients consecutively diagnosed with acute VKH, subacute VKH, multifocal central serous chorioretinopathy (CSCR), and posterior scleritis. All patients underwent OCT, fundus photography, and fluorescein angiography (FA) before treatment.

Chiral N,N'-Dioxide-Organocatalyzed Regio-, Diastereo- and Enantioselective Michael Addition-Alkylation Reaction.

A highly regio-, diastereo- and enantioselective Michael addition-alkylation reaction between α-substituted cyano ketones and (Z)-bromonitrostyrenes has been realized by using a chiral N,N'-dioxide as organocatalyst. A variety of substrates performed well in this reaction, and the corresponding multifunctionalized chiral 2,3-dihydrofurans were obtained in up to 95 % yield with 95:5 dr and 93 % ee.

[Analysis of the Characteristics of Infantile Small World Neural Network Node Properties Correlated with the Influencing Factors].

We applied resting-state functional magnetic resonance imaging(rfMRI)combined with graph theory to analyze 90 regions of the infantile small world neural network of the whole brain.We tried to get the following two points clear:1 whether the parameters of the node property of the infantile small world neural network are correlated with the level of infantile intelligence development;2 whether the parameters of the infantile small world neural network are correlated with the children’s baseline parameters,i.e.

Neutrophils in cancer development and progression: Roles, mechanisms, and implications (Review).

Neutrophils are predominant immune cells that protect the host from microbial infection. The roles of neutrophils in tumor have long been ignored due to their short life span and terminal differentiation phenotype. In recent years, emerging evidence indicates that neutrophils have phenotypic and functional plasticity.

Multigenerational effects of tris(1,3-dichloro-2-propyl) phosphate on the free-living ciliate protozoa Tetrahymena thermophila exposed to environmentally relevant concentrations and after subsequent recovery.

Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is considered a re-emerging environmental pollutant, and exposure to environmentally relevant concentrations has been shown to cause individual developmental toxicity in zebrafish and the water flea (Daphnia magna). However, multigenerational effects during exposure to TDCIPP and after subsequent recovery were unknown. In the present study, individuals of a model aquatic organism, the ciliated protozoan, T.

Experimental Quantum Randomness Processing Using Superconducting Qubits.

Coherently manipulating multipartite quantum correlations leads to remarkable advantages in quantum information processing. A fundamental question is whether such quantum advantages persist only by exploiting multipartite correlations, such as entanglement. Recently, Dale, Jennings, and Rudolph negated the question by showing that a randomness processing, quantum Bernoulli factory, using quantum coherence, is strictly more powerful than the one with classical mechanics.

Chronic intermittent hypoxia induces cardiac hypertrophy by impairing autophagy through the adenosine 5'-monophosphate-activated protein kinase pathway.

Autophagy is tightly regulated to maintain cardiac homeostasis. Impaired autophagy is closely associated with pathological cardiac hypertrophy. However, the relationship between autophagy and cardiac hypertrophy induced by chronic intermittent hypoxia (CIH) is not known.

A ,'-dioxide/Mg(OTf) complex catalyzed enantioselective α-addition of isocyanides to alkylidene malonates.

A highly efficient catalytic asymmetric α-addition of isocyanides to alkylidene malonates was accomplished. The process was based on the utilization of a chiral ,'-dioxide/Mg catalyst, delivering a variety of 2-alkyl-5-aminooxazoles in up to 99% yield and 96% ee under mild reaction conditions. Besides, a chiral imide and dipeptide could be easily obtained by ring-opening of the oxazole product, both of which are important structural motifs for many biologically active compounds.

Comprehensive mutation screening for 10 genes in Chinese patients suffering very early onset inflammatory bowel disease.

Aim: To perform sequencing analysis in patients with very early-onset inflammatory bowel disease (VEO-IBD) to determine the genetic basis for VEO-IBD in Chinese pediatric patients.

Methods: A total of 13 Chinese pediatric patients with VEO-IBD were diagnosed from May 2012 and August 2014. The relevant clinical characteristics of these patients were analyzed.