Carbon dot decorated CoO nanozymes responsive to the NIR-II window for mild photothermal-enhanced nanocatalytic therapy.

Although NIR-II laser-mediated photothermal therapy (PTT) is considered as an emerging strategy for tumor therapy, its therapeutic effects are still seriously hampered by low photothermal conversion efficacy, limited tissue penetration depth, and inevitable damage to adjoining healthy tissues. Herein, we report a mild second-near-infrared (NIR-II) photothermal-augmented nanocatalytic therapy (NCT) nanoplatform based on CD@CoO heterojunctions by depositing NIR-II-responsive carbon dots (CDs) onto the surface of CoO nanozymes. The as-prepared CoO nanozymes possess multi-enzyme-mimicking catalytic activity including peroxidase, catalase, and glutathione-peroxidase to realize the cascade amplification of ROS levels owing to the presence of multivalent Co and Co.

PTEN Lipid Phosphatase Activity Enhances Dengue Virus Production through Akt/FoxO1/Maf1 Signaling.

Dengue virus (DENV) is an arthropod-borne viral pathogen and a global health burden. Knowledge of the DENV-host interactions that mediate virus pathogenicity remains limited. Host lipid metabolism is hijacked by DENV for virus replication in which lipid droplets (LDs) play a key role during the virus lifecycle.

[Short-term response of carbon emission to snow cover change in Calamagrostis angustifolia wetlands of Sanjiang Plain, Northeast China].

To understand the response of Calamagrostis angustifolia wetland of the Sanjiang Plain to changes in snow cover, we examined the greenhouse gases emission flux of the removed snow treatment (0 cm, RS), the added snow treatment (50 cm, AS) and the control (20 cm, CK) of a C. angustifolia wetland, and their relations with environmental factors with the method of the static chamber-gas chromatography. The results showed that soil temperature, soil water content, and carbon emissions were lowest during the snow-covering period under all treatments, and gradually increased with time.

Characterizing the limits of human stability during motion: perturbative experiment validates a model-based approach for the Sit-to-Stand task.

Falls affect a growing number of the population each year. Clinical methods to assess fall risk usually evaluate the performance of specific motions such as balancing or Sit-to-Stand. Unfortunately, these techniques have been shown to have poor predictive power, and are unable to identify the portions of motion that are most unstable.

Long non-coding RNA MALAT1 promotes angiogenesis and immunosuppressive properties of HCC cells by sponging miR-140.

Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer in adults. Previous studies in our laboratory found that long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was upregulated in HCC cells, which could affect the metastasis and invasion of HCC. However, the underlying mechanism remains unknown.

Responses of greenhouse gas emission to simulated nitrogen deposition in Calamagrostis angustifolia wetlands of Sanjiang Plain, China.

A long-term simulated nitrogen deposition experiment was carried out in Ecological Locating Research Station of the Institute of Nature and Ecology of Heilongjiang Academy of Sciences, with three different treatments including low nitrogen treatment (40 kg N·hm·a), high nitrogen treatment (80 kg N·hm·a) and the control (0 kg N·hm·a). The greenhouse gas emission fluxes were measured using a static box-gas chromatography method, with environmental factors being simultaneously investigated to understand the responses of greenhouse gas emission to the nitrogen deposition in the Calamagrostis angustifolia wetland. The results showed that low and high nitrogen treatments significantly increased the greenhouse gas emission fluxes.

Serum levels of miRNA in patients with hepatitis B virus-associated acute-on-chronic liver failure.

Background: Hepatitis B virus (HBV)-associated acute-on-chronic liver failure (HBV-ACLF) is a life-threatening condition and its exact pathophysiology and progression remain unclear. The present study aimed to assess the role of serum miRNAs in the evaluation of HBV-ACLF and to develop a model to predict the outcomes for ACLF.

Methods: Serum was collected from 41 chronic hepatitis B and 55 HBV-ACLF patients in addition to 30 chronic asymptomatic HBV carriers as controls.

Early hepatitis B viral DNA clearance predicts treatment response at week 96.

Aim: To investigate whether hepatitis viral DNA load at 24 wk of treatment predicts response at 96 wk in patients with chronic hepatitis B.

Methods: A total of 172 hepatitis B envelope antigen (HBeAg)-positive chronic hepatitis B patients who received initial treatment at 16 tertiary hospitals in Hunan Province, China were enrolled in this study. All patients received conventional doses of lamivudine and adefovir dipivoxil, telbivudine, entecavir dispersible tablets, or entecavir tablets for 96 wk.

Novel HBV mutations and their value in predicting efficacy of conventional interferon.

Background: Accumulating studies assessing the impacts of hot spot mutations on conventional interferon (IFN) efficacy come to discrepant conclusions; studies regarding the mutations in S and RT regions are also unclear. The present study aimed to evaluate the impacts of HBV mutations on the efficacy of conventional IFN.

Methods: A total of 126 patients who received conventional IFN treatment for 48 weeks were enrolled.

A novel prognostic score for acute-on-chronic hepatitis B liver failure.

Patients with acute-on-chronic hepatitis B liver failure (HBV-ACLF) show high morbidity and mortality. Independent prognostic predictors of short-term HBV-ACLF mortality include the Child-Turcotte-Pugh (CTP) score, the model for end-stage liver disease (MELD) score, other MELD-based indices and the dynamic changes in these indices. The aims of this study were to evaluate the existing prognostic scores in a large cohort of HBV-ACLF patients and create a new predictive model.

Soft Tissue Deformations Contribute to the Mechanics of Walking in Obese Adults.

Unlabelled: Obesity not only adds to the mass that must be carried during walking but also changes body composition. Although extra mass causes roughly proportional increases in musculoskeletal loading, less well understood is the effect of relatively soft and mechanically compliant adipose tissue.

Purpose: This purpose of this study was to estimate the work performed by soft tissue deformations during walking.

Arctigenin promotes apoptosis in ovarian cancer cells via the iNOS/NO/STAT3/survivin signalling.

Arctigenin is a biologically active lignan extracted from the seeds of Arctium lappa and shows anticancer activity against a variety of human cancers. The aim of this study was to determine the effects of arctigenin on ovarian cancer cell proliferation and survival and associated molecular mechanisms. Human ovarian cancer OVCAR3 and SKOV3 cells were treated with arctigenin, and cell proliferation and apoptosis were assessed.

A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a serious life-threatening malignant disease of liver. Molecular targeted therapies are considered a promising strategy for the treatment of HCC. Sorafenib is the first, and so far the only targeted drug approved by the US Food and Drug Administration (FDA) for clinical therapy of HCC.

ARHI overexpression induces epithelial ovarian cancer cell apoptosis and excessive autophagy.

Objective: ARHI is a maternally imprinted tumor suppressor gene that is responsible for initiating programmed cell death and inhibiting cancer cell growth. However, the influence of ARHI on epithelial ovarian cancer cell death and the underlying mechanisms behind how ARHI regulates cancer cells still require further studies.

Methods: Epithelial ovarian cancer cells TOV112D and ES-2 were used in this in vitro study.

SC-535, a novel oral multikinase inhibitor, showed potent antitumor activity in human melanoma models.

Background: Melanoma is considered as one of the most aggressive and deadliest cancers and current targeted therapies of melanoma often suffer limited efficacy or drug resistance. Discovery of novel multikinase inhibitors as anti-melanoma drug candidates is still needed.

Methods: In this investigation, we assessed the in vitro and in vivo anti-melanoma activities of SC-535, which is a novel small molecule multikinase inhibitor discovered by us recently.

STAT3 acetylation-induced promoter methylation is associated with downregulation of the ARHI tumor-suppressor gene in ovarian cancer.

ARHI is a Ras-related imprinted tumor-suppressor gene that inhibits cancer cell growth and motility. ARHI is downregulated in the majority of ovarian cancer cells, and promoter methylation is considered to be associated with its loss of expression. however, the underlying mechanisms are not well understood.

[Application of acellular allograft dermal tissue patch in the repair of transvaginal rectovaginal fistula].

Objective: To investigate the clinical effect of acellular allograft dermal tissue patch used in transvaginal rectovaginal fistula repair.

Methods: From Jan. 2008 to Dec.

[Effect of microRNA on proliferation caused by mutant HBx in human hepatocytes].

To study the effect of micro (mi)RNA on cellular proliferation induced by hepatitis B x protein, HBx, in human liver cells and to investigate the underlying molecular mechanism of this cancer-related effect. The human L02 hepatocyte cell line was stably transfected with HBx (L02/HBx) or an HBx mutant (L02/HBx-d382) that induces higher levels of cellular proliferation. The differential miRNA expression profiles were determined by microarray analysis and confirmed by real-time PCR.

[DNA content and its correlation with biological behavior of non-small cell lung cancer].

Objective: To analyze the relationship between DNA content and biological behavior and its prognostic significance in non-small cell lung cancer.

Methods: Tumor DNA content was determined by flow cytometry in the specimens from 58 patients with resected non-small cell lung cancer. The DNA content of each cell subpopulation was expressed as the DNA index (DI), and an internal standard was provided by the normal pulmonary parenchymal cells in the same specimen.