World J Clin Cases
February 2023
Background: We report on a large family of Chinese Han individuals with hidrotic ectodermal dysplasia (HED) with a variation in (c.31G>A). The patients in the family had a triad of clinical manifestations of varying degrees.
View Article and Find Full Text PDFStudies have previously documented that microRNAs (miRNAs), with their key roles in regulating both synaptic plasticity and brain development, are candidate genetic contributors to the etiopathology of bipolar disorder (BD). Moreover, miRNA identified as targets for the actions of chronic lithium and VPA are known to play diverse and intriguing roles in brain function. In particular, the brain specific miR-134 has recently been identified as a potential regulator of dendritic spine volume and synapse formation.
View Article and Find Full Text PDF