Publications by authors named "Xiao Yaping"
Article Synopsis
- The study investigates the levels of microplastics (MPs) in the blood of patients with extracranial artery stenosis (ECAS) to understand their potential link to cardiovascular diseases.
- It involves 20 ECAS patients and 10 control subjects, revealing significantly higher MPs concentrations in the ECAS group (174.89 vs 79.82 μg/g).
- The findings suggest a correlation between higher MPs levels and more severe arterial stenosis, along with differences in blood markers like D-dimer and Thrombin Time between the two groups.
Article Synopsis
- * Results show that the group using TCC had a higher rate of excellent and good fracture reduction (100%) compared to the control group (92.6%), and they experienced less varus angle loss and shorter recovery time for full weight-bearing.
- * However, TCC patients had significantly higher intraoperative blood loss, while no significant differences were found in Harris scores or survival rates between the two groups, suggesting TCC may enhance treatment efficacy despite the increased
Article Synopsis
- Strategic coordination between urbanization and carbon emission efficiency (CEE) is crucial for sustainable urban planning, with research using models to assess how these factors influence each other in 106 countries from 2005 to 2020.
- The study finds that while global CEE is decreasing, it is unevenly distributed, with wealthier countries in Europe showing higher CEE compared to lower-income regions in Asia and Africa.
- The research indicates fluctuations in the coupled coordination degree (CCD) of urbanization and CEE, with suggestions for improving coordination through urban electrification and policy changes aimed at better integrating these two areas.
Article Synopsis
- The study aimed to identify serum biochemical markers that can predict the risk of hemorrhagic transformation (HT) in patients undergoing endovascular treatment (EVT) for anterior circulation large vessel occlusion (ACLVO).
- It included 180 patients, finding that monocyte count, activated partial thromboplastin time, and eosinophil count were independent predictors of HT, with specific warning values identified for each.
- Combining demographic data with these biochemical markers improved the prediction accuracy for HT in patients treated with EVT, indicating that monitoring these markers could be beneficial for risk assessment.
SIRT4 promotes neuronal apoptosis in models of Alzheimer's disease via the STAT2-SIRT4-mTOR pathway.
Am J Physiol Cell Physiol
June 2024
Article Synopsis
- - Alzheimer’s disease (AD) causes significant neuronal loss and dementia, with SIRT4's role in AD being an area of investigation, particularly regarding its impact on apoptosis and amyloid-β deposition.
- - The study utilized APP/PS1 mice and Aβ-treated HT-22 cells to assess SIRT4 expression and its effects on apoptosis and learning/memory function, finding that higher SIRT4 levels correlate with increased neuronal apoptosis and amyloid-β accumulation.
- - Reducing SIRT4 expression through genetic knockdown led to less apoptosis and amyloid-β buildup, resulting in improved memory in mouse models, highlighting the potential of targeting the STAT2-SIRT4-mTOR pathway for new AD treatment approaches.
Article Synopsis
- Patellofemoral osteoarthritis (PFJOA) is a type of knee osteoarthritis that mainly affects postmenopausal women, leading to significant anterior knee pain; the study aimed to explore this condition using an ovariectomized rat model.
- The researchers induced PFJOA in the rats through surgeries and treated some with Alendronate (ALN), which is known to inhibit bone loss, to observe its effects on joint health over 10 weeks.
- Results indicated that PFJOA leads to cartilage and bone degeneration, but early ALN treatment showed promise in slowing these degenerative changes and improving joint microstructure in the ovariectomized rats.
Background: The shortcomings of plaster in water resistance, air permeability, skin comfort, fixed stability and weight of wearing are still to be solved. 3D printed cast can overcome the above shortcomings. At present, there is a relative lack of data on the clinical application of 3D printed cast, probably due to its complexity, relatively long operating time, and high price.
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- - China's economic development has resulted in substantial emissions and environmental damage, making green development essential for sustainable growth and addressing these challenges.
- - A study evaluates the green development efficiency of 30 Chinese provinces using a specific index system and the Supe-SBM model, revealing significant spatial and temporal differences in efficiency levels.
- - Findings indicate that the eastern region has the highest green development efficiency, while central provinces lag behind and show a downward trend; factors like technological progress and urbanization positively influence efficiency, whereas industrial structure and financial development have negative impacts.
Article Synopsis
- * It analyzed data from 195 patients treated within 24 hours of admission, finding correlations between mortality and various factors, including age, blood glucose, blood pressure, and heart rate at different time points.
- * The results indicate that vital signs and glucose levels are significant indicators for predicting the prognosis of ICH patients after surgery, with specific thresholds identified for assessing risk at discharge and follow-ups.
Article Synopsis
- The study looked at patients with severe strokes who were treated successfully but still had bad outcomes or deaths in the following 90 days.
- It involved 207 people from a trial in China and found that 38% had poor results, while 12.6% died after treatment.
- Key risk factors for dying or having bad outcomes included being older than 67, having specific types of artery blockage, and having a high initial stroke severity score.
Article Synopsis
- Effective management of water resources is crucial for a country's economic development, and the study focuses on assessing the water resource green efficiency (CWRGE) across 108 cities in the Yangtze River Economic Belt from 2006 to 2021 using the Super-SBM model.
- Overall, the CWRGE has not reached effective levels, showing a fluctuating "W"-shaped trend, with only seven cities achieving effective data envelopment analysis rankings.
- The study highlights disparities in CWRGE based on city size and location, revealing that larger cities perform better, with downstream cities exhibiting the highest efficiencies, while various factors like economic development and industrial scale positively influence CWRGE, contrary to foreign direct investment and environmental regulation, which
Article Synopsis
- Brand management is a crucial yet often neglected aspect in the development of higher education institutions, impacting their reputation and competitiveness.
- A systematic review of 43 relevant journal articles from 2000-2021 analyzes key elements such as brand positioning, identity, and marketing strategies related to universities.
- The paper aims to provide insights for university administrators and encourage further research by highlighting valuable lessons from corporate marketing practices that can enhance a university's competitive advantages.
Article Synopsis
- - China's rapid urbanization is straining land resources, raising issues about how to effectively use limited land for social, economic, and environmental benefits.
- - An assessment of green land use efficiency in cities along the Yangtze River from 2005 to 2019 revealed overall inefficiency, with megacities performing best and upstream regions showing lower efficiency levels.
- - Factors like population density and environmental regulations positively influence urban land green use efficiency, while economic development and land use scale can hinder it; recommendations for improvement are provided based on these findings.
Article Synopsis
- - The global climate issue is worsening due to high carbon dioxide emissions, presenting a challenge for countries to reduce emissions while fostering economic development.
- - The study analyzes carbon emission efficiency across 136 countries from 2000 to 2019, finding significant disparities, with only a few countries, mostly in Europe, achieving high efficiency while many in Asia and Africa lag significantly behind.
- - Utilizing the Tobit model, the research identifies factors influencing carbon emission efficiency, highlighting that developed countries perform better than developing ones, which aligns with the environmental Kuznets curve theory.
Article Synopsis
- The study examined how intravenous thrombolysis (IVT) affects the growth of the ischemic core in acute ischemic stroke patients with large vessel occlusion.
- Researchers analyzed data from 94 patients, comparing those who received IVT to those who did not, and found that the core growth rate was significantly lower in the IVT group.
- IVT showed more effectiveness in reducing core growth in patients with poor collateral circulation, but there were no noticeable differences in clinical outcomes after three months between the two groups.
Article Synopsis
- The study aimed to compare the safety and efficacy of the Neurohawk retriever and the Solitaire FR for treating acute ischemic stroke caused by large vessel occlusion, using a randomized controlled trial with a focus on non-inferiority.
- A total of 232 patients participated, showing a successful reperfusion rate of 88.70% for Neurohawk and 90.60% for Solitaire, with no significant differences in safety outcomes or overall effectiveness between the two devices.
- Subgroup analyses indicated that both devices performed similarly in terms of outcomes, regardless of whether the strokes were caused by intracranial atherosclerotic disease or other factors, with comparable rates of all-cause mortality within 90 days.
Article Synopsis
- - The study focuses on evaluating the energy efficiency of China's construction industry in the Yangtze River Economic Belt (YREB) using the Super-EBM model to assess green total-factor energy efficiency (CIGTFEE) from 2003 to 2018, amidst goals for carbon neutrality.
- - Results reveal a general growth in CIGTFEE over the period, with varying trends across different regions: downstream areas peaked until 2006, while midstream followed an "M" shape and upstream regions displayed an inverted U-shape; significant spatial agglomeration was also observed.
- - Key drivers of CIGTFEE include economic growth, energy structure, and human capital, with urbanization having a negative effect
Article Synopsis
- Glucose and lactate are essential for tumor growth, making their simultaneous removal a significant challenge in cancer treatment.
- A new system called FPGLC has been developed using fluorinated polymer to co-load glucose oxidase and lactate oxidase, which depletes glucose and lactate while generating hydrogen peroxide.
- The system also includes catalase to convert hydrogen peroxide into oxygen, which helps enhance the therapy's effectiveness, alleviate tumor hypoxia, and improve the delivery and imaging of treatment in tumors.
Article Synopsis
- - The study aimed to compare two methods for fixing femoral neck fractures: the novel Dynamic Compression Locking System (DCLS) and the traditional Dynamic Hip Screw (DHS), in terms of stability, healing, and complications.
- - Fifty patients were analyzed, with 26 treated using DCLS and 24 using DHS, focusing on differences in operation time, blood loss, rehabilitation, and post-op outcomes over 24 months.
- - Results indicated that the DCLS group experienced less surgical trauma, shorter operation times, and higher recovery scores compared to the DHS group, although both methods had similar reoperation rates.
Article Synopsis
- Several studies suggest that the protein PTH1-34 could be a potential treatment for osteoarthritis (OA) and osteoporosis, but its effectiveness for patella baja-induced patellofemoral joint OA (PFJOA) hasn't been explored yet.
- In this study, researchers induced PFJOA in rats and divided them into groups to compare outcomes between a control group and those treated with PTH1-34 over a period of 10 weeks.
- Results showed that PTH1-34 significantly improved cartilage metabolism and subchondral bone health, reversing negative effects like cartilage degeneration and bone microstructure deterioration caused by PFJOA.
Article Synopsis
- A prospective cohort study examined the safety and effectiveness of mechanical thrombectomy (MT) in patients with mild ischemic strokes caused by large vessel occlusion (LVO).
- The study compared two groups: those receiving MT and those receiving the best medical management (MM), using propensity score matching to reduce biases.
- Results indicated that while there were no significant differences in complication rates, the MT group showed higher rates of functional independence and excellent outcomes, suggesting MT may be beneficial for patients with mild symptoms from anterior circulation strokes.
Article Synopsis
- * Researchers created a three-dimensional model of the NVU using neural stem cells and endothelial cells in a Matrigel matrix, which mimics the real NVU structure and function.
- * The 3D NVU model not only reflects cerebral ischemia damage under stress conditions but also aids in studying potential treatments that promote healing in neurovascular diseases, such as enhancing blood vessel and nerve cell growth.
Article Synopsis
- Diabetic nephropathy (DN) is a serious complication of diabetes with limited treatment options, leading researchers to investigate epiberberine (EPI) as a potential protective agent.
- A study conducted on db/db mice and kidney cells showed that EPI improved blood sugar levels, renal function, and reduced kidney damage over an 8-week period.
- Additionally, EPI was found to inhibit specific gene expressions related to kidney damage, particularly the gene Angiotensinogen (Agt), suggesting that Agt is crucial for EPI's protective effects against DN.
Article Synopsis
- Rhizoma Coptidis (RC) is a traditional Chinese medicine known for its effectiveness in treating diabetes, and modern studies affirm its benefits, particularly focusing on its alkaloids.
- This study aimed to explore the impact of total Rhizoma Coptidis alkaloids (TRCA) on diabetic nephropathy (DN) by employing network pharmacology and transcriptomic analysis.
- Results indicated that TRCA treatment improved fasting blood glucose levels, body weight, renal function, and lipid profiles in db/db mice, demonstrating its potential therapeutic effects on DN.
Article Synopsis
- Bone cement leakage is a significant complication in treating Kümmell's disease via percutaneous vertebroplasty, leading to a study of clinical outcomes with and without leakage.
- The research included 64 patients, dividing them into two groups based on bone cement leakage observed in X-rays, and compared various health metrics and outcomes before and after surgery.
- Results showed that patients with leakage had more severe disease characteristics, but both groups experienced improvements in pain and disability post-surgery without significant differences between them.