[Development of needle-thread integrative embedding needle].

The needle-thread integrative embedding needle consists of needle handle, needle core, thread, locker and needle guard. The thread is fixed in the core by the locker. With the needle inserted into acupoint, the locker is separated from the thread, while the thread is embedded directly into acupoint, to achieve one acupoint with one needle.

Clinical Characteristics and Gene Mutations of Two Families with MODY 3 in Inner Mongolia.

Objective: This study aimed to analyze the clinical characteristics and gene mutations of two families with maturity-onset diabetes of the young 3 (MODY 3) in Inner Mongolia.

Methods: Fifty-three patients in Inner Mongolia suspected of having MODY 3 were enrolled in this study according to clinical manifestations. Blood samples were collected, and all exons of the gene were analyzed; the second-generation DNA of the splicing regions of the gene was determined by direct sequencing.

Proteomic profiling of cerebrospinal fluid in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease.

Background: Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an autoimmune demyelinating disorder of the central nervous system.

Methods: Extracted proteins from 34 cerebrospinal fluid (CSF) samples [patients with MOGAD (MOG group, n = 12); healthy controls (HC group, n = 12); patients with MOG seronegative and metagenomics next-generation sequencing-negative inflammatory neurological diseases (IND group, n = 10)] were processed and subjected to label-free quantitative proteomics. Supervised partial least squares-discriminant analysis (PLS-DA) and orthogonal PLS-DA (O-PLS-DA) models were also performed based on proteomics data.

Pressure effect of the mechanical, electronics and thermodynamic properties of Mg-B compounds A first-principles investigations.

First principle calculations were performed to investigate the structural, mechanical, electronic properties, and thermodynamic properties of three binary Mg-B compounds under pressure, by using the first principle method. The results implied that the structural parameters and the mechanical properties of the Mg-B compounds without pressure are well matched with the obtainable theoretically simulated values and experimental data. The obtained pressure-volume and energy-volume revealed that the three Mg-B compounds were mechanically stable, and the volume variation decreases with an increase in the boron content.

[International standard -: experience and recommendation].

The 22236 --, as the first international standard (IS) in acupoint thread-embedding field, has been officially published by International Organization for Standardization (ISO) in 2020. The background of its development, difficulties and countermeasures in the process of development were reviewed, and the experience of standard development was summarized, aiming to provide methods and references for future IS development of acupuncture and moxibustion instruments. It is suggested that strengthening the discourse power in the process of IS development, increasing the compound talents cultivation for IS, valuing the importance of enterprises in the development of IS, and creating an advantageous environment for the development of IS are the keys to improve the level of standardization of acupuncture and moxibustion instruments and play a more important role in the IS development.

Genome-wide identification and characterization of DCL, AGO and RDR gene families in Saccharum spontaneum.

RNA silencing is a conserved mechanism in eukaryotic organisms to regulate gene expression. Argonaute (AGO), Dicer-like (DCL) and RNA-dependent RNA polymerase (RDR) proteins are critical components of RNA silencing, but how these gene families' functions in sugarcane were largely unknown. Most stress-resistance genes in modern sugarcane cultivars (Saccharum spp.

Clinical Efficacy and Safety of Major Uterine Wall Resection and Reconstruction of the Uterus Combined with LNG-IUS for the Treatment of Severe Adenomyosis.

Aim of the study was to evaluate the clinical efficacy and safety of major uterine wall resection and reconstruction of the uterus (MURU) combined with a levonorgestrel-releasing intrauterine system (LNG-IUS) for the treatment of adenomyosis. Ninety patients diagnosed with adenomyosis were enrolled in this study. All participants were examined by transvaginal ultrasound (TVU) or magnetic resonance imaging (MRI).

Effect of P content on microstructure and wear properties of ZCuPbSn alloy.

The properties and friction behavior of ZCuPbSn modified with P were investigated. With the P addition and content increase, the second phase appeared and gradually increased in amount. Also, the microstructure of ZCuPbSn was refined and evenly distributed.

Microstructure analysis and mechanical properties of phosphorus-reinforced ZCuPb20Sn5 alloy.

An investigation was carried out to assess the effect of the P content on the microstructure and mechanical properties of ZCuPb20Sn5 alloy. Alloys of various compositions, (0.05, 0.

Association between expression of HOTAIR and invasiveness of gliomas, and its predictive value.

Background: Hox transcript antisense intergenic RNA (HOTAIR) is upregulated and associated with a poor prognosis in many cancer types. Besides, it is involved in the invasion and metastasis of non-small-cell lung cancer and nasopharyngeal carcinoma.

Objectives: The aim of this study was to investigate the association between the expression of HOTAIR and the grades of gliomas, and to explore its possible mechanism, as well as to evaluate the value of HOTAIR applied in predicting the grades of gliomas.

Experimental study on ablation of leiomyoma by combination high-intensity focused ultrasound and iodized oil in vitro.

Aim: The aim of the current study was to investigate whether iodized oil (IO) enhances high-intensity focused ultrasound (HIFU) ablation of uterine leiomyoma and to determine the features of hyperechoic changes in the target region.

Methods: Forty samples of uterine leiomyoma were randomly divided into an experimental group and a control group. In the experimental group, the leiomyoma was ablated by HIFU 30 min after 1 mL of iodized oil had been injected into the center of the myoma.

Energetics and kinetics of Cu atoms and clusters on the Si(111)-7 × 7 surface: first-principles calculations.

Exploring the properties of noble metal atoms and nano- or subnano-clusters on the semiconductor surface is of great importance in many surface catalytic reactions, self-assembly processes, crystal growth, and thin film epitaxy. Here, the energetics and kinetic properties of a single Cu atom and previously reported Cu magic clusters on the Si(111)-(7 × 7) surface are re-examined by the state-of-the-art first-principles calculations based on density functional theory. First of all, the diffusion path and high diffusion rate of a Cu atom on the Si(111)-(7 × 7) surface are identified by mapping out the total potential energy surface of the Cu atom as a function of its positions on the surface, supporting previous experimental hypothesis that the apparent triangular light spots observed by scanning tunneling microscopy (STM) are resulted from a single Cu atom frequently hopping among adjacent adsorption sites.

Origin of Symmetric Dimer Images of Si(001) Observed by Low-Temperature Scanning Tunneling Microscopy.

It has been a long-standing puzzle why buckled dimers of the Si(001) surface appeared symmetric below ~20 K in scanning tunneling microscopy (STM) experiments. Although such symmetric dimer images were concluded to be due to an artifact induced by STM measurements, its underlying mechanism is still veiled. Here, we demonstrate, based on a first-principles density-functional theory calculation, that the symmetric dimer images are originated from the flip-flop motion of buckled dimers, driven by quantum tunneling (QT).

H18 Carbon: A New Metallic Phase with sp2-sp3 Hybridized Bonding Network.

Design and synthesis of three-dimensional metallic carbons are currently one of the hot issues in contemporary condensed matter physics because of their fascinating properties. Here, based on first-principles calculations, we discover a novel stable metallic carbon allotrope (termed H18 carbon) in () symmetry with a mixed sp(2)-sp(3) hybridized bonding network. The dynamical stability of H18 carbon is verified by phonon mode analysis and molecular dynamics simulations, and its mechanical stability is analyzed by elastic constants, bulk modulus, and shear modulus.

Upregulated ROS production induced by the proteasome inhibitor MG-132 on XBP1 gene expression and cell apoptosis in Tca-8113 cells.

Exposure of Tca-8113 cells to proteasome inhibitor carbobenzoxy-Leu-Leu-leucinal (MG-132) causing apoptosis is associated with endoplasmic reticulum (ER) stress. X-box-binding protein-1 (XBP1) is an important regulator of a subset of genes active during ER stress, which is related to cell survival and is required for tumor growth. The present study is to evaluate the effect of MG-132 on ROS production, XBP1 gene expression, tumor necrosis factor receptor-associated factor 2 (TRAF2), ASK1 and c-jun protein expression in tongue squamous cell carcinoma cell line Tca-8113 cells.

Increased expression of matrix metalloproteinase-9 associated with gastric ulcer recurrence.

Aim: To compare matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1 in gastric ulcer (GU) and chronic superficial gastritis (CSG).

Methods: This study enrolled 63 patients with GU and 25 patients with CSG. During upper gastroduodenal endoscopy, we took samples of gastric mucosa from the antrum and ulcer site from patients with GU, and samples of antral mucosa from patients with CSG.

Ischemic preconditioning protects against spinal cord ischemia-reperfusion injury in rabbits by attenuating blood spinal cord barrier disruption.

Ischemic preconditioning has been reported to protect against spinal cord ischemia-reperfusion (I-R) injury, but the underlying mechanisms are not fully understood. To investigate this, Japanese white rabbits underwent I-R (30 min aortic occlusion followed by reperfusion), ischemic preconditioning (three cycles of 5 min aortic occlusion plus 5 min reperfusion) followed by I-R, or sham surgery. At 4 and 24 h following reperfusion, neurological function was assessed using Tarlov scores, blood spinal cord barrier permeability was measured by Evan's Blue extravasation, spinal cord edema was evaluated using the wet-dry method, and spinal cord expression of zonula occluden-1 (ZO-1), matrix metalloproteinase-9 (MMP-9), and tumor necrosis factor-α (TNF-α) were measured by Western blot and a real-time polymerase chain reaction.

[Clinical analysis of hypoparathyroidism with altered serum muscle enzymes: report of 41 cases].

Objective: To examine the clinical features of hypoparathyroidism (HP) with altered serum muscle enzymes and explore the correlations with age, gender, disease duration, serum total calcium, serum total phosphorus and parathyroid hormone (PTH).

Methods: From January 2005 to October 2011, a total of 41 HP patients at our hospital were retrospectively analyzed.

Results: There were 16 patients with elevated serum muscle enzymes and 25 with normal serum muscle enzymes.

1-(4-Chloro-phen-yl)-1H-pyrazol-3-ol.

In the title compound, C(9)H(7)ClN(2)O, the dihedral angle between the aromatic ring planes is 11.0 (2)°. In the crystal, inversion dimers linked by pairs of O-H⋯N hydrogen bonds generate R(2) (2)(8) loops.

Tetra-pyridine-bis(trichloro-acetato)nickel(II).

The title compound, [Ni(C(2)Cl(3)O(2))(2)(C(5)H(5)N)(4)], was prepared by the reaction of pyridine and trichloro-acetatonickel(II) in ethanol solution at room temperature. The Ni(II) atom is located on a twofold rotation axis and has a slightly distorted octa-hedral coordination made up of four N atoms of the pyridine ligands and two O atoms of trichloro-acetate anions. The mol-ecular structure and packing are stabilized by intra- and inter-molecular C-H⋯O hydrogen-bonding inter-actions.

2-[(3-Bromo-phen-yl)imino-meth-yl]phenol.

The title compound, C(13)H(10)BrNO, was prepared by reaction of 3-bromo-aniline with 2-hydroxy-benzaldehyde at 377 K. The mol-ecular structure and packing are stabilized by an intra-molecular O-H⋯N hydrogen-bond inter-action.

N-(4-Chloro-benzyl-idene)-4-methoxy-aniline.

The title compound, C(14)H(12)ClNO, was prepared by the reaction of 4-methoxy-aniline and 4-chloro-benzaldehyde in ethanol at 367 K. The mol-ecule is almost planar, with a dihedral angle between the two benzene rings of 9.1 (2)° and an r.

4-(4-Amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridinium chloride.

The crystal structure of the title compound, C(7)H(8)N(5)S(+)·Cl(-), is stabilized by inter-molecular N-H⋯Cl and N-H⋯S hydrogen-bond inter-actions.

3-(2-Pyrid-yl)-N-p-tolyl-indolizin-1-amine.

In the title compound, C(20)H(17)N(3), there are four mol-ecules in the asymmetric unit. The dihedral angles between the indolizine ring system and the pyridyl ring are 6.6 (2), 7.

4-Meth-oxy-N-(2-nitro-benzyl-idene)aniline.

The title compound, C(14)H(12)N(2)O(3), was prepared by reaction of 2-nitro-benzaldehyde with 4-methoxy-benzenamine at 377 K. The molecule has an E configuration, with a dihedral angle between the two benzene rings of 43.3 (5)°.