An integrated framework of life-cycle environmental, human health, and economic impact assessment for urban water systems.

Water scarcity presents a pressing and lasting challenge to many large cities, necessitating adaptations in urban water systems. Developing reliable water resources is crucial for enhancing water security, yet concerns regarding costs and environmental impacts persist. To address this, we have developed an integrated framework that combines life cycle assessment (LCA), quantitative microbial risk assessment (QMRA), and life cycle costing (LCC) for evaluating the environmental, public health, and economic impacts of water systems.

Comparative Study of Trans-Axillary Approach and Delto-Pectoral Approach to the Treatment of Ideberg Types I and II Scapular Glenoid Fractures.

Objective: Clinically, simple glenoid fractures are less prevalent, and surgical treatment of anterior glenoid fractures is often based on the classic anterior approach (delto-pectoral approach), while there are few reports on the efficacy of the trans-axillary approach. The objective of this study is to explore the clinical efficacy of both approaches in the treatment of Ideberg Types I and II scapular glenoid fractures.

Methods: The trans-axillary approach is the surgical method of exposing a glenoid fracture along the anterior edge of the latissimus dorsi muscle through an axillary incision.

Species Diversity of Section in Southwestern China, with a Description of Three New Species.

Species of sect. are challenging to delimitate due to the morphological similarity among different taxa. In this study, morphological characteristics, molecular phylogenetic data, and ecological traits were integrated to investigate the species diversity of this section of southwestern China.

Hydrochemical and isotopic characteristics and water transformation relationships in the Zhenglan Banner section of Shandian River Basin, China.

Water resources are essential for sustaining life, driving economic development, and protecting the environment. We investigated the hydrochemical variations of surface water and groundwater in the Shandian River Basin to identify the driving factors and the transformation relationship between each water body. Precipitation data was collected from May to October 2023, while surface water and groundwater samples were collected in both August (wet season) and October (dry season).

Surface-hydrogenated CrMnO coupled with GaN nanowires for light-driven bioethanol dehydration to ethylene.

Light-driven bioethanol dehydration offers attractive outlooks for the sustainable production of ethylene. Herein, a surface-hydrogenated CrMnO is coupled with GaN nanowires (GaN@CMO-H) for light-driven ethanol dehydration to ethylene. Through combined experimental and computational investigations, a surface hydrogen-replenishment mechanism is proposed to disclose the ethanol dehydration pathway over GaN@CMO-H.

[Metabolomics combined with bioinformatics reveals mechanism of Sanhuang Hushen Fangshuai Decoction in treating chronic kidney disease].

This article aims to analyze the therapeutic effect and probe into the mechanism of Sanhuang Hushen Fangshuai Decoction in treating chronic kidney disease(CKD) based on metabolomics and bioinformatics. The patients with stage 3-4 CKD diagnosed and treated in the Changzhou Hospital of Traditional Chinese Medicine from June 2023 to March 2024 were enrolled in this study. The patients were treated with Sanhuang Hushen Fangshuai Decoction, and the therapeutic effect was evaluated.

CT-based nomogram predicts esophageal gastric variceal bleeding in noncirrhotic portal hypertension caused by hepatic schistosomiasis.

Background: To construct a nomogram combining CT varices vein evaluation and clinical laboratory tests for predicting the risk of esophageal gastric variceal bleeding (EGVB) in patients with noncirrhotic portal hypertension (NCPH).

Methods: A total of 315 NCPH patients with non-EGVB and EGVB were retrospectively enrolled and randomly divided into training and testing cohorts. Thirteen collateral vessels were identified and evaluated after CT portal vein system reconstruction.

Deciphering the N-substituent effects on biodegradation of sulfonamides: Novel insights revealed from molecular biology and computational chemistry approaches.

Elucidating biodegradation mechanisms and predicting pollutant reactivities are essential for advancing the application of biodegradation engineering to address the challenge of thousands of emerging contaminants. Molecular biology and computational chemistry are powerful tools for this purpose, enabling the investigation of biochemical reactions at both the gene and atomic levels. This study employs the biodegradation of ten sulfonamide antibiotics as a case study to demonstrate the integration of genomics and quantum chemistry approaches in exploring the biodegradation behavior of emerging contaminants.

Eye Movement and Gait Variability Analysis in Chinese Patients With Huntington's Disease.

Objective: Huntington's disease (HD) is characterized by motor, cognitive, and neuropsychiatric symptoms. Oculomotor impairments and gait variability have been independently considered as potential markers in HD. However, an integrated analysis of eye movement and gait is lacking.

Three new species of the genus Oedichirus Erichson, 1839 (Coleoptera: Staphylinidae: Paederinae: Pinophilini) from China.

Three new species of Oedichirus Erichson, 1839 are described: Oedichirus haishengensis Duan, Yue & Li sp. nov. from Guangxi Province, O.

Current innovations in mRNA vaccines for targeting multidrug-resistant ESKAPE pathogens.

The prevalence of multidrug-resistant (MDR) ESKAPE pathogens, including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa, represents a critical global public health challenge. In response, mRNA vaccines offer an adaptable and scalable platform for immunotherapy against ESKAPE pathogens by encoding specific antigens that stimulate B-cell-driven antibody production and CD8 T-cell-mediated cytotoxicity, effectively neutralizing these pathogens and combating resistance. This review examines recent advancements and ongoing challenges in the development of mRNA vaccines targeting MDR ESKAPE pathogens.

Solvent Effect on Cation⊗3π Interactions: A First-Principles Study.

Cation⊗3π interactions play a special role in the behaviors of biological molecules and carbon-based materials in aqueous solutions, yet the effects of solvation on these interactions remain poorly understood. This study examines the sequential attachment of water molecules to cation⊗3π systems (cation = Li⁺, Na⁺, K⁺), revealing that solvation influences interaction strengths in opposing ways: solvation of the metal cation decreases the strengths of cation⊗3π interactions, while the solvation of the benzene molecule increases the strengths of cation⊗3π interactions, compared with the strengths of cation⊗3π interactions in the gas phase. The mechanism analyses revealed that in the presence of surrounding water molecules, the stability of cation⊗3π systems is generally enhanced by cation-π, π-π, water-π, and water-ion interactions, while water-water interactions typically have a destabilizing effect.

A DFT Study of Band-Gap Tuning in 2D Black Phosphorus via Li, Na, Mg, and Ca Ions.

Black phosphorus (BP) and its two-dimensional derivative (2D-BP) have garnered significant attention as promising anode materials for electrochemical energy storage devices, including next-generation fast-charging batteries. However, the interactions between BP and light metal ions, as well as how these interactions influence BP's electronic properties, remain poorly understood. Here, we employed density functional theory (DFT) to investigate the effects of monovalent (Li and Na) and divalent (Mg and Ca) ions on the valence electronic structure of 2D-BP.

Enhancing transjugular intrahepatic portosystemic shunt procedure efficiency with digital subtraction angiography image overlay technology in esophagogastric variceal bleeding.

Background: Transjugular intrahepatic portosystemic shunt (TIPS) is a pivotal intervention for managing esophagogastric variceal bleeding in patients with chronic hepatic schistosomiasis.

Aim: To evaluate the efficacy of digital subtraction angiography image overlay technology (DIT) in guiding the TIPS procedure.

Methods: We conducted a retrospective analysis of patients who underwent TIPS at our hospital, comparing outcomes between an ultrasound-guided group and a DIT-guided group.

Development and validation of a nomogram for individualizing fall risk in patients with hematologic malignancies.

Inpatient falls are common adverse events especially for patients with hematologic malignancies. A fall-risk prediction model for patients with hematologic malignancies are still needed. Here we conducted a multicenter study that prospectively included 516 hospitalized patients with hematologic malignancies, and developed a nomogram for fall risk prediction.

[Correlation of anti-C1q antibodies with active systemic lupus erythematosus and lupus nephritis in children].

Objectives: To study the correlation of anti-C1q antibodies with active systemic lupus erythematosus (SLE) and lupus nephritis (LN) in children, as well as their diagnostic value for active SLE and LN.

Methods: A retrospective selection of 90 hospitalized children with SLE at the Children's Medical Center of Second Xiangya Hospital, Central South University from January 2016 to March 2019 as the SLE group, all of whom were tested for anti-C1q antibodies. A control group was formed by collecting 70 hospitalized children with other autoimmune diseases (OAD) during the same period.

[Clinical characteristics of children with anti-neutrophil cytoplasmic antibody-associated vasculitis].

Objectives: To study the clinical characteristics of children with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

Methods: A retrospective analysis was conducted on the clinical data of 25 children diagnosed with AAV at the Second Xiangya Hospital of Central South University from January 2010 to June 2022.

Results: Among the AAV children, there were 5 males and 20 females, with a median age of onset of 11.

Rescue path planning for urban flood: A deep reinforcement learning-based approach.

Urban flooding is among the costliest natural disasters worldwide. Timely and effective rescue path planning is crucial for minimizing loss of life and property. However, current research on path planning often fails to adequately consider the need to assess area risk uncertainties and bypass complex obstacles in flood rescue scenarios, presenting significant challenges for developing optimal rescue paths.

Plasmid-mediated azithromycin resistance in non-typhoidal Salmonella recovered from human infections.

Objectives: Mechanisms of non-typhoidal Salmonella (NTS) resistance to azithromycin have rarely been reported. Here we investigate the epidemiology and genetic features of 10 azithromycin-resistant NTS isolates.

Methods: A total of 457 NTS isolates were collected from a tertiary hospital in Guangzhou.

Iron driven organic carbon capture, pretreatment, recovery and upgrade in wastewater: Process technologies, mechanisms, and implications.

Wastewater treatment plants face significant challenges in transitioning from energy-intensive systems to carbon-neutral, energy-saving systems, and a large amount of chemical energy in wastewater remains untapped. Iron is widely used in modern wastewater treatment. Research shows that leveraging the coupled redox relationship of iron and carbon can redirect this energy (in the form of carbon) towards resource utilization.

Mmp14-dependent remodeling of the pericellular-dermal collagen interface governs fibroblast survival.

Dermal fibroblasts deposit type I collagen, the dominant extracellular matrix molecule found in skin, during early postnatal development. Coincident with this biosynthetic program, fibroblasts proteolytically remodel pericellular collagen fibrils by mobilizing the membrane-anchored matrix metalloproteinase, Mmp14. Unexpectedly, dermal fibroblasts in Mmp14-/- mice commit to a large-scale apoptotic program that leaves skin tissues replete with dying cells.

Mauritone A, a new polyketide from a fungal-bacterial symbiont GXIMD 04541/ GXIMD 04532.

A new polyketide, mauritone A () with six known polyketides curvulone B (), curvularin (), 12-oxocurvularin (), (10,15)-10,11-dehydrocurvularin (), (11,15)-11-hydroxycurvularin (), and (11,15)-11-hydroxycurvularin () were isolated from the fungal-bacterial symbiont GXIMD 04541/ GXIMD 04532 derived from . Their structures were elucidated by extensive spectral analysis. All compounds (-) were evaluated for their anti-inflammatory effects.