Publications by authors named "Xiao Xue Zi"
Background: Asthma is one of the most common chronic diseases among children and adults and can lead to a high health and socioeconomic burden. Allergic rhinitis (AR) often precedes the development of asthma. This study aims to clarify the risk factors for cocurrent asthma in patients with AR in eastern China.
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- Nasal inverted papilloma (NIP) is a benign tumor linked to increased expression of Yes-associated protein (YAP), which plays a role in airway epithelium growth.
- Research compared YAP levels across NIP, nasal polyp (NP), and control groups, finding YAP expression significantly higher in NIP and related to cell proliferation and inflammation.
- The study suggests that abnormal YAP expression correlates with NIP severity and negative patient outcomes, highlighting its potential as a target for diagnosis and treatment.
Background: Visual Analog Scale (VAS) as determined by the patient is recommended by the European Position Paper on Rhinosinusitis and Nasal Polyps 2012 in evaluation of the total severity of the chronic rhinosinusitis (CRS) patients' symptoms.
Objective: To evaluate the correlation between evaluations performed by otorhinolaryngologists and CRS patients with commonly used systems.
Methods: Scores of VAS and Sino-Nasal Outcome Test-20 (SNOT-20) Chinese version were obtained from 110 CRS patients with nasal polyps (CRSwNPs, n = 61) and without nasal polyps (CRSsNPs, n = 49) before surgery, which were compared with scores of Lund-Kennedy endoscopic staging system, the Lund-Mackay computed tomography (CT) staging system, and VAS from 3 attending otorhinolaryngologists.
Nasal polyp (NP) is a chronic upper airway inflammatory disease that is frequently triggered by defective host-defense. However, the mechanisms underlying the impaired barrier function such as cilia-mediated mucociliary clearance remain poorly understood. To assess ciliary ultrastructural and ciliogenesis marker expression and the phenotypes of ciliated cells in NP.
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- The study aimed to uncover the genetic pathways linked to chronic rhinosinusitis with nasal polyps (CRSwNP) by analyzing gene expressions in affected and non-affected tissue samples.
- Researchers conducted RNA sequencing on tissues from CRSwNP patients and compared them to controls, identifying key differentially expressed genes (DEGs) related to immune regulation and cilium function.
- Findings suggested that gene patterns connected to immune dysfunction, inflammation, and tissue remodeling play a crucial role in CRSwNP, paving the way for potential new therapies targeting these pathways.
Olfactory Change Pattern after Endoscopic Sinus Surgery in Chronic Rhinosinusitis with Olfactory Dysfunction.
J Coll Physicians Surg Pak
August 2018
Objective: To determine the change pattern of olfactory function in chronic rhinosinusitis (CRS) with olfactory dysfunction after endoscopic sinus surgery (ESS), and its association with inspection scores.
Study Design: Observational study.
Place And Duration Of Study: Second Hospital of Shandong University, China, from December 2014 to January 2016.
Purpose Of Review: Impaired mucociliary clearance has been implicated in chronic upper and lower airway inflammatory diseases (i.e., allergic and non-allergic rhinitis, chronic rhinosinusitis with or without nasal polyps and asthma).
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