Publications by authors named "Xiao Xi Fan"

An increasing number of patients with advanced non-small cell lung cancer (NSCLC) have a poor prognosis and develop progressive disease after receiving conventional treatments. In recent years, several novel therapies have been approved for later lines of therapy of previously treated NSCLC. Erlotinib, an EGFR tyrosine kinase inhibitor, was recommended as the second-line therapy for pre-treated patients.

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The evidence of current epidemiological studies investigating the relationship between preoperative anemia and progression of lung cancer (LC) patients remains controversial. The PubMed, EMBASE, and Web of Science databases were comprehensively searched by two independent authors to identify related epidemiological studies from inception through January 31, 2019. Similarly, two researchers separately extracted data and any differences were resolved by discussion.

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Colorectal cancer (CRC) is one of the most common malignancies, giving rise to serious financial burden globally. This study was designed to explore the potential mechanisms implicated with CRC and identify some key biomarkers. CRC-associated gene expression dataset (GSE32323) was downloaded from GEO database.

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Epidemiological evidences regarding the association between physical activity and the risk of lung cancer are still controversial. We aimed to investigate the relationship between physical activity and risk of lung cancer in men and women, as well as other high-risk populations such as cigarette smokers. We conducted a meta-analysis of cohort studies to evaluate the association between physical activity and risk of lung cancer.

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Our study aims to evaluate the efficacy of transcatheter arterial chemoembolization in the treatment of patients with liver metastasis using integrated F-fluorodeoxyglucose positron emission tomography/computed tomography. A total of 97 liver metastasis patients treated by transcatheter arterial chemoembolization were enrolled in this study. The F-fluorodeoxyglucose positron emission tomography/computed tomography images of liver metastasis patients were collected before and after transcatheter arterial chemoembolization treatment.

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Article Synopsis
  • The study examines how silencing CXCR7 using a lentiviral vector affects tumor invasion and metastasis in hepatocellular carcinoma (HCC) following transcatheter arterial chemoembolization (TACE).
  • Experiments involved cultured HCC cells and a rat model, comparing groups treated with CXCR7-shRNA, TACE, and negative controls to evaluate the effects on cell growth, invasion, and tumor characteristics.
  • Results showed that CXCR7-shRNA reduced the expression of key proteins (CXCR7, MMP-2, VEGF), decreased tumor size, improved survival, and lowered metastasis in treated rats compared to control groups.
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