Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential.

Periodontal ligament fibroblasts (PDLFs) play a crucial role in the etiology of periodontitis and periodontal tissue regeneration. In healthy periodontal tissues, PDLFs maintain the homeostasis of periodontal soft and hard tissues as well as the local immune microenvironment. PDLFs also have the potential for multidirectional transdifferentiation and are involved in periodontal tissue regeneration.

Epigenetic regulation by naringenin and naringin: A literature review focused on the mechanisms underlying its pharmacological effect.

Epigenetics refers to heritable changes in gene expression or phenotypic changes that occur without changing the gene sequence. The main methods of epigenetics include non-coding RNA, histone modification, and DNA modification, which play an essential role in gene expression regulation and even the occurrence of diverse diseases. Naringenin, the aglycone form of naringin, is a natural flavonoid compound mainly found in fruits or plant derivatives such as citrus, tomatoes, and cherries.

Predictive value of three nutritional indexes for disease activity in patients with inflammatory bowel disease.

Background: Malnutrition is prevalent in patients with inflammatory bowel disease (IBD); however, its ability to predict the disease activity in IBD remains unexplored. Therefore, this study aimed to explore the association between malnutrition and disease activity in IBD.

Methods: In this retrospective study, we enrolled 1006 patients diagnosed with IBD from the First Affiliated Hospital of Wenzhou Medical University from 2011 to 2022.

Superior Temperature Sensing and Capacitive Energy-Storage Performance in Pb-Free Ceramics.

The ultrafast charge/discharge rate and high power density (P) endow lead-free dielectric energy storage ceramics (LDESCs) with enormous application potential in electric vehicles. However, their low energy storage density and single energy storage performance (ESP) limit their further development and applicability in rugged environments. Here, through the design of vacancy defects and phase structure regulation, Pb-free (BiNa)TiO-based ceramics with an optimal composition can achieve a large maximum polarization (>44 µC cm) under a moderate electric field (410 kV cm), resulting in an extremely high recoverable energy storage density (≈6.

Novel benzothiazole derivatives target the Gac/Rsm two-component system as antibacterial synergists against infections.

The management of antibiotic-resistant, bacterial biofilm infections in skin wounds poses an increasingly challenging clinical scenario. infection is difficult to eradicate because of biofilm formation and antibiotic resistance. In this study, we identified a new benzothiazole derivative compound, (IC = 43.

AdipoRon mitigates liver fibrosis by suppressing serine/glycine biosynthesis through ATF4-dependent glutaminolysis.

AdipoRon has been validated for its ability to reverse liver fibrosis, yet the underlying mechanisms remain to be thoroughly investigated. Collagen, predominantly synthesized and secreted in hepatic stellate cells (HSCs), relies on glycine as a crucial constituent. Activating transcription factor 4 (ATF4) serves as a pivotal transcriptional regulator in amino acid metabolism.

The effectiveness of revocable precommitment strategies in reducing decision-making impulsivity.

Precommitment shows promise in reducing decision-making impulsivity; however, it may be invalidated, leading to self-control failures. Therefore, this study aimed to explore the effectiveness of revocable precommitment in promoting commitment and reducing decision-making impulsivity through two studies. Experiment 1 used event-related potentials to explore whether revocable precommitment was beneficial to make individuals more inclined to commit.

GABA and its receptors' mechanisms in the treatment of insomnia.

Insomnia has now become a major health problem of global concern, with about 1/3 of the population suffering from sleep problems, a proportion that is still rising year by year. Most of the therapeutic drugs for insomnia currently used in clinical practice are not developed in a targeted manner, but are discovered by chance, and have unavoidable side effects such as addiction. Finding a safer and more effective therapeutic drug has become an urgent need for current research.

Influence of TyG Index on Large Vascular Occlusive Stroke Following Endovascular Treatment.

Aims: This study aimed to investigate the impact of the triglyceride-glucose index (TyG index) on clinical consequences in individuals with large vascular occlusion (LVO)-induced acute ischemic stroke (AIS) following endovascular treatment (EVT).

Methods: We conducted a single-center retrospective cohort study, including AIS with LVO who underwent EVT. Patients were categorized into TyG index groups, calculated as "(fasting triglyceride [mg/dL] × fasting blood glucose [mg/dL]/2).

Characteristics of polycystic ovary syndrome rat models induced by letrozole, testosterone propionate and high-fat diets.

Research Question: What are the long-term effects of different models of polycystic ovary syndrome (PCOS), and which model could be used in future research?

Design: PCOS models induced by letrozole, letrozole plus high-fat diet (LE+HFD), testosterone propionate (TP) or testosterone propionate plus HFD (TP+HFD) were established in rats. Body weight, energy intake, blood glucose, sex hormone concentrations, lipid profiles and the oestrus cycle were observed. Histology of ovaries, large intestine and fat was displayed.

Thermodynamically Dependent Behavior in Gas Transport in Two-Dimensional Graphene Nanochannels.

Gas transport through nanochannels has aroused significant interest in many fields. Recently, "ballistic transport" of gas was observed through a two-dimensional graphene nanochannel, and it causes a peculiar enhancement compared to the predictions of the Knudson theory. Many studies attributed this effect to the specular reflection caused by the atomically smooth surface of the channel.

1H-MRS parameters in non-enhancing peritumoral regions can predict the recurrence of glioblastoma.

This study aimed to evaluate the predictive value of metabolic parameters in preoperative non-enhancing peritumoral regions (NEPTRs) for glioblastoma recurrence, using multivoxel hydrogen proton magnetic resonance spectroscopy (1H-MRS). Clinical and imaging data from patients with recurrent glioblastoma were analyzed. Through co-registration of preoperative and post-recurrence MRI, we identified future tumor recurrence regions (FTRRs) and future non-tumor recurrence regions (FNTRRs) within the NEPTRs.

Inhibition of miR-20a-5p Suppresses Epithelial-Mesenchymal Transition of Colorectal Cancer Cells Through GJA1.

This study was designed to clarify the role of GJA1 in colorectal cancer. qPCR was adopted to detect the GJA1 and miR-20a-5p expression levels in tumor tissues and cells; and EdU, Transwell assay, Scratch test to examine the migration, invasion, and proliferation of colorectal cancer cells. The EMT-related protein expression was measured by immunofluorescence and western Blot.

Monolayer Amphiphiles Hydrophobicize MoS-Mediated Real-Time Water Removal for Efficient Waterproof Hydrogen Detection.

Ensuring water-fouling-free operation of semiconductor-based gas sensors is essential to maintaining their accuracy, reliability, and stability across diverse applications. Despite the use of hydrophobic strategies to prevent external water intrusion, addressing in situ-produced water transport during H detection remains a challenge. Herein, we construct a novel waterproof H sensor by integrating single-atom Ru self-assembly with monolayer amphiphiles embedded in MoS.

Exploration of a Novel Terpolymer Nanoparticle System for the Prevention of Alcohol-Induced Dose Dumping.

Alcohol-induced dose dumping (AIDD) remains a serious challenge in the controlled delivery of high potency drugs, such as opioids, which requires extensive investigation and innovative solutions. Current technologies rely on ethanol-insoluble excipients, such as guar gum and sodium alginate, to counteract the increased solubility of hydrophobic polymeric excipients in ethanol. However, these excipients pose several shortcomings, such as high viscosity of coating dispersion, high solution temperature, rapid gelation, and heterogeneity of resulted film.

Exploring the therapeutic potential of yeast β-glucan: Prebiotic, anti-infective, and anticancer properties - A review.

Yeast β-glucan (YBG), an indigestible polysaccharide from yeast cell walls, is multifunctional. It plays a pivotal role in regulating gut microbiota (GM) and boosting the immune system, which is central to research on inflammation, cancer, and metabolic diseases. By modulating the GM, YBG exhibits various prebiotic effects, including hypoglycemic, hypolipidemic, and immune-regulating properties.

Polyelectrolyte fabricated nanofiltration membrane with heterogeneously charged channels for high efficient cephalexin wastewater treatment.

Nanofiltration (NF) for treatments of pharmaceutical wastewater is a promising direction for water protection and resources recovery. Herein, a novel membrane with heterogeneously charged channels was constructed by modified layer-by-layer assembly methods. Within the well-designed pores, the polyanion structure excludes the cephalexin and the cationic structure slows down its diffusion, thereby rejections for cephalexin are improved.

High-efficiency second-harmonic generation in reverse-polarization dual-layer lithium niobate waveguides.

Second-harmonic (SH) generation is an important way to generate short-wavelength light sources. Thin-film lithium niobate (TFLN) resonators and waveguides featuring tight light confinement are flexible to realize mode- or quasi-phase-matching (MPM or QPM) and thus efficient SH generation. Here, we report an efficient SH with an absolute conversion efficiency of 45% in a reverse-polarized double-layer TFLN waveguide.