Carabrone Attenuates Metabolic Dysfunction-Associated Steatohepatitis by Targeting STAT3 in Mice.

Metabolic dysfunction-associated steatohepatitis (MASH) has become one of the most common progressive liver diseases worldwide, but effective treatment options are severely unmet. Carabrone, a sesquiterpene lactone from the traditional Chinese herb L., shows various pharmacological properties, whereas its effect on the improvement of MASH and the underlying mechanisms have not yet been reported.

NK cells in renal cell carcinoma and its implications for CAR-NK therapy.

Renal cell carcinoma (RCC) is a malignancy that makes up 3% of adult cancers and 20%-30% of patients were diagnosed with metastatic RCC in the beginning, while the median overall survival (OS) of metastatic RCC systemic therapy ranges from 16 months to 50 months. Immunotherapy, a novel therapy that relies on the specific binding of immune cells and tumor cells, may be a potential therapy for advanced renal cell carcinoma. While chimeric antigen receptor NK-cell (CAR-NK) therapy has been investigated in a variety of solid tumors, specific research on its application to RCC has also been reported by several teams.

Decoding dengue's neurological assault: insights from single-cell CNS analysis in an immunocompromised mouse model.

Background: Dengue encephalitis, a severe neurological complication of dengue virus infection, is increasingly recognized for its rising incidence and significant public health burden. Despite its growing prevalence, the underlying mechanisms and effective therapeutic strategies remain poorly understood.

Methods: Cellular atlas of dengue encephalitis was determined by single-nucleus RNA sequencing.

Individual Graph Representation Learning for Pediatric Tooth Segmentation from Dental CBCT.

Pediatric teeth exhibit significant changes in type and spatial distribution across different age groups. This variation makes pediatric teeth segmentation from cone-beam computed tomography (CBCT) more challenging than that in adult teeth. Existing methods mainly focus on adult teeth segmentation, which however cannot be adapted to spatial distribution of pediatric teeth with individual changes (SDPTIC) in different children, resulting in limited accuracy for segmenting pediatric teeth.

A novel classification method for LUAD that guides personalized immunotherapy on the basis of the cross-talk of coagulation- and macrophage-related genes.

Purpose: The coagulation process and infiltration of macrophages affect the progression and prognosis of lung adenocarcinoma (LUAD) patients. This study was designed to explore novel classification methods that better guide the precise treatment of LUAD patients on the basis of coagulation and macrophages.

Methods: Weighted gene coexpression network analysis (WGCNA) was applied to identify M2 macrophage-related genes, and TAM marker genes were acquired through the analysis of scRNA-seq data.

Improved Natamycin Production in Through Mutagenesis and Enhanced Nitrogen Metabolism.

Natamycin is a polyene macrocyclic antibiotic extensively used in food, medical, and agricultural industries. However, its high production cost and low synthetic efficiency fail to meet the growing market demand. Therefore, enhancing the production of natamycin-producing strains is crucial for achieving its industrial-scale production.

KLF4: a multifunctional nexus connecting tumor progression and immune regulation.

Krüppel-like factors (KLFs) regulate various biological processes such as cell proliferation, migration, invasion, and differentiation as gene transcription factors. Signaling pathways which mediated by KLF4 and KLF4 have a sophisticated role in tumors due to multiple factors, including the types or stage of tumors. KLF4 plays a promoter role in tumorigenesis and development, or tumor suppressor as a context-dependent anti- and pro-inflammatory factor.

Chaihuang Qingfu Pills Protect Against Acute Pancreatitis-Associated Acute Lung Injury Through MMP9-NLRP3-Pyroptosis Pathway.

Background: Severe acute pancreatitis associated with acute lung injury (SAP-ALI) is a critical condition with a high mortality rate. Investigating the pathogenesis of SAP-ALI and developing effective treatments are urgently needed. Chaihuang Qingfu Pills (CHQF), a traditional Chinese medicine modified from Qingyi Decoction, has been approved for treating acute pancreatitis (AP).

The impact of dietary phosphorus levels on growth, slaughter, and digestive metabolism in growing sheep.

Phosphorus (P) pollution from livestock farming poses significant environmental challenges, necessitating efficient P utilization. This study systematically investigated the effects of varying dietary P levels on growth, slaughter performance, nutrient digestion, and metabolism in during the growth phase. Forty-five sheep (30.

ACSS3 promotes the tumorigenesis of non-small cell lung cancer via suppressing p53-mediated ferroptosis.

Non-small cell lung cancer (NSCLC) is a subtype of the most frequently diagnosed cancer, causing a considerable number of deaths globally. Mitochondrial dysfunction was found to promote malignant progression. However, the underlying mechanism remains unclear.

Continuous Provisioning Increases Breeding Success of Black-and-White Snub-Nosed Monkeys (Rhinopithecus bieti) in the Baima Snow Mountain Nature Reserve, Yunnan, China.

The high energy demands of primates during pregnancy and lactation often limit their breeding success due to the availability of food resources. Until now, few studies have focused on the effects of continuous provisioning on primate reproduction. To assess the impact of continuous provisioning on breeding success, we collected data on female reproductive status (primiparous or multiparous), maternal age of births, births, deaths, and sex of infants in a free-ranging semi-provisioned band (FSB) of Rhinopithecus bieti in China from 2010 to 2023.

Watershed: a more efficient sampling unit for mountain camera traps.

Wildlife camera trap (CT) surveys typically employ two-dimensional equal-area grid sampling, which often neglects the influence of complex mountainous terrain on species distribution, potentially yielding misleading outcomes. A watershed, incorporating diverse habitats from high to low elevations and from rivers to ridges, aligns with complex mountains. Monitoring based on watersheds might address this.

EXO1 is a key gene for lung-resident memory T cells and has diagnostic and predictive values for lung adenocarcinoma.

Lung adenocarcinoma (LUAD) is a very common and lethal kind of lung malignancy. An increasing number of studies indicated that tissue-resident memory T (T) cells played significant roles in anti-cancer immunity. In our previous study, EXO1 was found to be a core gene for T cells in the prognosis of LUAD.

Pharmacovigilance analysis of drug-induced hypofibrinogenemia using the FDA Adverse Event Reporting System.

Background: Drug-induced hypofibrinogenemia has received increasing scrutiny; however, the specific drugs involved remain poorly characterized. Hypofibrinogenemia can have significant clinical implications, including increased bleeding risks.

Aim: This study aimed to utilize the FDA Adverse Event Reporting System (FAERS) to identify and analyze drugs frequently implicated in drug-induced hypofibrinogenemia.

Identification and validation of prognostic biomarkers in ccRCC: immune-stromal score and survival prediction.

Background: The tumor microenvironment (TME) is integral to tumor progression. However, its prognostic implications and underlying mechanisms in clear cell renal cell carcinoma (ccRCC) are not yet fully elucidated. This study aims to examine the prognostic significance of genes associated with immune-stromal scores and to explore their underlying mechanisms in ccRCC.

Soybean oil and probiotics improve meat quality, conjugated linoleic acid concentration, and nutritional quality indicators of goats.

This study aimed to investigate the impact of dietary soybean oil and probiotics on goat meat quality, total conjugated linoleic acids (TCLA) concentration, and nutritional quality indicators of goats. Thirty-six male crossbred goats (Anglo-Nubian♂× Thai native♀), weighing 18.3 ± 2.

Scalable Synthesis of 2D ErOCl with Sub-meV Narrow Emissions at Telecom Band.

Van der Waals (vdWs) materials are promising candidates for hetero-integration with silicon photonics toward miniaturization and integration. VdWs materials like molybdenum telluride and black phosphorus, despite being prominent, exhibit air sensitivity, and their room temperature emissions can be significantly broadened by tens of meV. Here, a self-encapsulation strategy is developed to scalably synthesize robust 2D vdWs ErOCl with sub-meV narrow emissions at the telecom C-band.

The mediating role of core self-evaluation in the association between perceived peer relationship quality and loneliness in university students.

This study investigated the mediating role of core self-evaluation (CSE) in the relationship between the perception of peer relationship quality and loneliness among university students during the COVID-19 pandemic. An online survey was conducted with 462 university students (mean age: 20.7 ± 1.

Characteristics, risk factors and a risk prediction model of tocilizumab-induced hypofibrinogenemia: a retrospective real-world study of inpatients.

Objective: The occurrence of hypofibrinogenemia after tocilizumab treatment has attracted increasing attention, which may cause bleeding and even life-threatening. This study aims to explore the risk factors for tocilizumab-induced hypofibrinogenemia (T-HFIB) and construct a risk prediction model.

Methods: A total of 221 inpatients that received tocilizumab from 2015 to 2023 were retrospectively collected and divided into T-HFIB group or control group.

Partially substituting roughage with traditional Chinese herbal medicine residues in the diet of goats improved feed quality, growth performance, hematology, and rumen microbial profiles.

This study aimed to reveal the effect of traditional Chinese herbal medicine residues (TCHMR) on growth performance, hematology, ruminal microbiota, and economic benefits of Guizhou black male goats through the fermented total mixed ration (FTMR) diet technique. A total of 22 Guizhou black male goats with an initial weight of 21.77 ± 0.

Mitochondrial A Adenosine Receptor as a Mechanism for the Protective Effects of AAR Agonists on Chemotherapy-Induced Neuropathic Pain.

Alterations in mitochondrial function are the linchpin in numerous disease states including in the development of chemotherapy-induced neuropathic pain (CIPN), a major dose-limiting toxicity of widely used chemotherapeutic cytotoxins. In CIPN, mitochondrial dysfunction is characterized by deficits in mitochondrial bioenergetics (e.g.

Prognostic Value and Immunological Role of POP7 in Clear Cell Renal Cell Carcinoma.

Background: Studies have found that RNA-binding proteins (RBPs) are participated in the occurrence or development of tumours. However, the role of processing of precursor family (POP family) in clear cell renal cell carcinoma (ccRCC) has not been studied yet. Here, we analyzed the expression and prognostic value of POP family in ccRCC analyzed and subsequently revealed the relationship between POP7 and immune infiltration in ccRCC patients.