[Procyanidins enhance the chemotherapeutic sensitivity of laryngeal carcinoma cells to cisplatin through autophagy pathway].

Objectives: To investigate the effect of Procyanidins (OPCs) on the autophagy of laryngeal cancer cell line TU686 and to explore the effect of OPCs on the chemosensitivity of laryngeal cancer cells to DDP in terms of autophagy and apoptosis.

Methods: CCK-8 was used to detected the effect of different concentrations of OPC and DDP on TU686 cell viability. Experimental grouping: Both kinds of cells were divided into CON group, DDP group, OPC group and MIX group.

Development, Translation and Validation of Enhanced Asian Rome III Questionnaires for Diagnosis of Functional Bowel Diseases in Major Asian Languages: A Rome Foundation-Asian Neurogastroenterology and Motility Association Working Team Report.

Background/aims: The development-processes by regional socio-cultural adaptation of an Enhanced Asian Rome III questionnaire (EAR3Q), a cultural adaptation of the Rome III diagnostic questionnaire (R3DQ), and its translation-validation in Asian languages are presented. As English is not the first language for most Asians, translation-validation of EAR3Q is essential. Hence, we aimed to culturally adapt the R3DQ to develop EAR3Q and linguistically validate it to show that the EAR3Q is able to allocate diagnosis according to Rome III criteria.

The spectra, symptom profiles and overlap of Rome III functional gastrointestinal disorders in a tertiary center in South China.

Objective: Most previous studies exploring the overlap of functional gastrointestinal disorders (FGID) focus on the overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS). In this study, we aimed to explore the spectra, symptom profiles and overlap of all FGID using the validated Chinese version of the Rome III questionnaire.

Methods: Consecutive newly diagnosed FGID patients who were admitted to the Outpatient Gastroenterology Clinic from 10 May to 10 September 2012 were recruited in the study.