Stability of tryptophan-containing LOs in flaxseed oil and their response towards γ-tocopherol.

Linusorbs (LOs), significantly influence oil quality and sensory properties of flaxseed oil. Trp-containing LOs exhibit distinct oxidative behavior when γ-tocopherol (γ-T) is present. Polar fractions of crude flaxseed oil were stripped via silica absorption, and reintroduced (LO and γ-T) separately into the oil matrix to investigate their interaction during storage.

A case of IgG4-related interstitial nephritis with ureteral obstruction: case report and literature review.

Background: IgG4-related disease (IgG4-RD) is a newly discovered systemic disease that can affect any organ or tissue in the body. IgG4-related kidney disease (IgG4-RKD) is relatively rare but essential to IgG4-RD. However, there are few reports of IgG4-RD mimicking malignant ureteral tumors leading to hydronephrosis.

New HIV diagnoses in patients with COVID-19: two case reports and a brief literature review.

Background: COVID-19 is novel infectious disease with an evolving understanding of its epidemiology and clinical manifestations. Severe cases developed life-threatening complications, such as respiratory failure, shock, and multiple organs dysfunction. Immunocompromised patients often present atypical presentations of viral infected diseases.

Identification of catalytic and non-catalytic activity inhibitors against PRC2-EZH2 complex through multiple high-throughput screening campaigns.

Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 (PRC2) along with embryonic ectoderm development (EED) and suppressor of zeste 12 (SUZ12), which implements transcriptional repression mainly by depositing trimethylation marks at lysine 27 of histone H3 (H3K27me3). Its catalytic activity is closely correlated with the stability of PRC2, and somatic activating mutation of EZH2 Y641F within the catalytic SET domain drives tumor aggressiveness, drug resistance, and poor prognosis. Here, we report two high-throughput screening (HTS) campaigns targeting EZH2 Y641F and EZH2-EED interaction, respectively.

High-throughput screening campaign identifies a small molecule agonist of the relaxin family peptide receptor 4.

Relaxin/insulin-like family peptide receptor 4 (RXFP4) is a class A G protein-coupled receptor (GPCR), and insulin-like peptide 5 (INSL5) is its endogenous ligand. Although the precise physiological role of INSL5/RXFP4 remains elusive, a number of studies have suggested it to be a potential therapeutic target for obesity and other metabolic disorders. Since selective agonists of RXFP4 are scarcely available and peptidic analogs of INSL5 are hard to make, we conducted a high-throughput screening campaign against 52,000 synthetic and natural compounds targeting RXFP4.

Subclinical hypothyroidism is associated with lipid-rich plaques in patients with coronary artery disease as assessed by optical coherence tomography.

Background: Subclinical hypothyroidism (SCH) has recently been acknowledged as an unconventional risk factor for coronary artery disease (CAD) and characterized by poor prognosis, which may be due to atherosclerotic plaque characteristics. We conducted this study to observe coronary plaque characteristics in coronary artery disease patients with concomitant SCH.

Methods: Patients with coronary artery disease were enrolled in the study and divided into an SCH group (patients, = 26; plaques, = 35) and a non-SCH group (patients, = 52; plaques, = 66).

W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway.

Recent evidence shows that high glucose levels recruit carbohydrate response element-binding protein, which binds the promoter of thioredoxin-interacting protein (txnip), thereby regulating its expression in β-cells. Overexpression of txnip not only induces β-cell apoptosis but also reduces insulin production. Thus, the discovery of compounds that either inhibit TXNIP activity or suppress its expression was the focus of the present study.

The hydrogen-bonded complex bis(tert-butylammonium) 2,6-dichlorophenolate 2,4-dichlorophenol-2,4-dichlorophenolate tetrahydrofuran disolvate containing a chiral R(10) hydrogen-bonded ring as a supramolecular synthon.

A fixed hydrogen-bonding motif with a high probability of occurring when appropriate functional groups are involved is described as a `supramolecular hydrogen-bonding synthon'. The identification of these synthons may enable the prediction of accurate crystal structures. The rare chiral hydrogen-bonding motif R(10) was observed previously in a cocrystal of 2,4,6-trichlorophenol, 2,4-dichlorophenol and dicyclohexylamine.

A hydrogen-bonded three-component complex: bis(dicyclohexylammonium) 2,4-dichlorophenolate 2,4,6-trichlorophenolate 2,4-dichlorophenol.

The title complex, 2C12H24N(+)·C6H3Cl2O(-)·C6H2Cl3O(-)·C6H4Cl2O, consists of three different achiral components, dicyclohexylammonium cations, 2,4,6-trichlorophenolate anions and H-atom-bridged 2,4-dichlorophenolate/2,4-dichlorophenol units, held together by O-H···N and O-H···O hydrogen bonds to form a chiral hydrogen-bonded ring. A helical cylinder is established by the packing of these rings along a crystallographic 4₁ screw axes. Helical cylinders may be generated from each other by translation, resulting in the formation of the chiral crystal.

Relationship of inflammation and endothelial dysfunction with risks to cardiovascular disease among people in Inner Mongolia of China.

Objective: To explore the relationship of inflammation and endothelial dysfunction with risks to cardiovascular disease (CVD).

Methods: Blood pressure, body weight, body height, waist circumference and lifestyle risk factors were measured and studied among 2589 participants in Inner Mongolia of China, and biomarkers of inflammation and endothelial dysfunction including high-sensitivity C-reactive protein (hsCRP), soluble inter-cellular adhesion molecule-1 (sICAM-1), soluble E-selectin (sE-selectin), and angiotensin II were investigated.

Results: Subjects with metabolic risk factors for CVD had higher levels of hsCRP, sE-selectin and sICAM-1 than those without such risk factors (all P<0.

[Epidemiological study on hyperuricemia and gout in Foshan areas, Guangdong province].

Objective: To determine the prevalence rates and risk factors of hyperuricemia (HUA) and gout among residents aged over 20 years in Foshan areas.

Methods: A randomly stratified cluster sampling was conducted, and 7403 inhabitants were investigated on their prevalence rates of HUA and gout.

Results: (1) The prevalence of HUA was 15.

Comparative study of pathological lesions induced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation.

The pathological lesions induced by multiwalled carbon nanotubes (MWCNTs) in bronchi and alveoli of mice were studied by intratracheal instillation and inhalation. In instillation groups, the dose was 0.05 mg MWCNTs/mouse.

catena-Poly[[(2,2'-biimidazole-kappa2N,N')chlorocopper(II)]-mu-chloro].

In the polymeric title compound, [CuCl2(C6H6N4)]n, each CuII ion is five-coordinated by four basal atoms (two N atoms from a 2,2'-biimidazole molecule and two Cl- anions) and one axial Cl- anion, in a distorted square-pyramidal coordination geometry. Cl- anions bridge the {Cu(C6H6N4)Cl} units into one-dimensional linear chains, which are reinforced by pi-pi interactions. Adjacent linear chains are linked by N-H.

catena-Poly[[chloro(1,10-phenanthroline-kappa2N,N')copper(II)]-mu-imidazolato-kappa2N:N'].

In the polymeric title compound, [Cu(im)Cl(phen)](n), where im is the imidazolate anion (C(3)H(3)N(2)) and phen is 1,10-phenanthroline (C(12)H(8)N(2)), each Cu(II) ion is five-coordinated by four basal N atoms (two from two different im anions and two from one phen ligand) and one axial Cl atom, in a distorted square-pyramidal coordination geometry. Moreover, each im anion bridges two identical [CuCl(phen)](+) cations through its two N atoms, resulting in a one-dimensional zigzag chain along the crystallographic a axis. In addition, pairs of adjacent chains are staggered by pi-pi interactions, generating a two-dimensional layer, and neighbouring layers are further linked by two different kinds of C-H.