SynAsk: unleashing the power of large language models in organic synthesis.

The field of natural language processing (NLP) has witnessed a transformative shift with the emergence of large language models (LLMs), revolutionizing various language tasks and applications, and the integration of LLMs into specialized domains enhances their capabilities for domain-specific applications. Notably, NLP has made significant strides in organic chemistry, particularly in predicting synthetic tasks, paving the way for the development of LLMs tailored to the organic chemistry field. In this work, we introduce SynAsk, a comprehensive organic chemistry domain-specific LLM platform developed by AIChemEco Inc.

Extended Surface Bands Enabled Lasing Emission and Wavelength Switch from Sulfur Quantum Dots.

The development of a lasing wavelength switch, particularly from a single inorganic gain material, is challenging but highly demanded for advanced photonics. Nonetheless, all current lasing emission of inorganic gain materials arises from band-edge states, and the inherent fixed bandgap limitation of the band-edge system leads to the inaccessibility of lasing wavelength switching from a single inorganic gain material. Here the realization of a single inorganic gain material-based lasing wavelength switch is reported by proposing an alternative lasing emission strategy, that is, lasing emission from surface gain.

Association between hyperuricemia and chronic total coronary occlusion in non-chronic kidney disease populations: a cross-sectional study.

Background: Chronic total coronary occlusion (CTO) is an extremely hazardous condition that leads to various clinical phenomena and complications and results in social and economic burdens. Hyperuricemia (HU) is often associated with atherosclerosis. Few studies, however, have investigated the risk of CTO in individuals with HU and the role of traditional cardiovascular risk factors in this setting.

Effects of Dietary Leaf Extract Supplementation on Growth Performance, Meat Quality, Antioxidant Capacity, and Lipid Metabolism of Finishing Pigs.

This study aimed to investigate the effects of dietary leaf extract (ELE) on meat quality, antioxidant capacity, and lipid metabolism in finishing pigs. A total of 240 "Duroc × Landrace × Yorkshire" crossbred pigs with an initial weight of 74.70 ± 0.

The Effects of Unconventional Feed Fermentation on Intestinal Oxidative Stress in Animals.

Unconventional feed, which is abundant in China, contains anti-nutritional factors and toxins; however, these can be greatly reduced with microbial fermentation, thus improving the nutrient content of the feed, enhancing animal appetites, and ultimately significantly improving the intestinal health and growth performance of animals. When oxidative stress occurs, fermented feed can effectively reduce the damage caused by stress to the gastrointestinal tract, accelerate the removal of gastrointestinal abnormalities, improve the ability to resist intestinal stress, and ensure the efficient production of animals. This review introduces the application of unconventional fermented feed in animal production, and expounds upon the function of unconventional fermented feed in animals with oxidative stress symptoms, so as to provide a theoretical reference for the development and application of unconventional fermented feed in antioxidative stress reduction.

Multicolor Fluorescent Inks Based on Lanthanide Hybrid Organogels for Anticounterfeiting and Logic Circuit Design.

With the rapid development of information technology, the encrypted storage of information is becoming increasingly important for human life. The luminescent materials with a color-changed response under physical or chemical stimuli are crucial for information coding and anticounterfeiting. However, traditional fluorescent materials usually face problems such as a lack of tunable fluorescence, insufficient surface-adaptive adhesion, and strict synthesis conditions, hindering their practical applications.

CsPbBr Quantum Dots Promoted Depolymerization of Oxidized Lignin via Photocatalytic Semi-Hydrogenation/Reduction Strategy.

Due to the demanding depolymerization conditions and limited catalytic efficiency, enhancing lignin valorization remains challenging. Therefore, lowering the bond dissociation energy (BDE) has emerged as a viable strategy for achieving mild yet highly effective cleavage of bonds. In this study, a photocatalytic semi-hydrogenation/reduction strategy utilizing CsPbBr quantum dots (CPB-QDs) and Hantzsch ester (HEH ) as a synergistic catalytic system was introduced to reduce the BDE of C -O-Ar, achieving effective cleavage of the C -O-Ar bond.

Association between the triglyceride glucose index and chronic total coronary occlusion: A cross-sectional study from southwest China.

Background And Aim: Insulin resistance (IR) plays an important role in the atherosclerotic process, and the triglyceride glucose (TyG) index is a reliable indicator of IR and is strongly associated with cardiovascular disease. However, there are few studies regarding the relationship between the TyG index and chronic total coronary occlusion (CTO). Herein, the correlation between the TyG index and CTO, as well as their interactions with other traditional cardiovascular risk factors, were investigated.

Relation Between Calcium-Phosphorus Product and Total Coronary Artery Occlusion in a Nonchronic Kidney Disease Population: A Cross-Sectional Study.

Excessive calcium-phosphorus product (Ca-P product) in patients with chronic kidney disease (CKD) is associated with coronary artery calcification and coronary artery disease, but the relation between Ca-P product and coronary artery disease in non-CKD populations has rarely been reported. Therefore, we designed a cross-sectional study to investigate the role of Ca-P product in total coronary artery occlusion (TCAO) in a non-CKD population. We reviewed 983 patients who underwent coronary angiography at Guangyuan Central Hospital from February 2018 to January 2020.

2D Collagen Membranes from Marine Demosponge (Nardo, 1847) for Skin-Regenerative Medicine Applications: An In Vitro Evaluation.

Research in tissue engineering and regenerative medicine has an ever-increasing need for innovative biomaterials suitable for the production of wound-dressing devices and artificial skin-like substitutes. Marine collagen is one of the most promising biomaterials for the production of such devices. In this study, for the first time, 2D collagen membranes (2D-CMs) created from the extracellular matrix extract of the marine demosponge have been evaluated in vitro as possible tools for wound healing.

H-type hypertension is a risk factor for chronic total coronary artery occlusion: a cross-sectional study from southwest China.

Background: Chronic total coronary occlusion (CTO) is serious and the "last bastion" of percutaneous coronary intervention. Hypertension and hyperhomocysteinemia (HHCY) are synergistic and significantly increase cardiovascular event risk. The relationship between H-type hypertension and CTO remains unclear; thus, this cross-sectional study investigated this potential association.

Dome-shaped mode lasing from liquid crystals for full-color lasers and high-sensitivity detection.

In this communication, we report a new class of oscillation mode, dome-shaped mode (DSM), in liquid crystal (LC) microlasers. A record high -factor over 24 000 is achieved in LC soft-matter microlasers. We successfully presented a proof-of-concept demonstration of red, green, blue (RGB) LC-DSM microlaser pixels with a 74% broader achievable color gamut than the standard RGB color space.

The relationship between hyperhomocysteinemia and total coronary artery occlusion: a cross-sectional study from Southwest China.

Background: Increasing evidence points to hyperhomocysteinemia as an independent risk factor for coronary artery disease in addition to traditional cardiovascular risks, but few have studied the association between hyperhomocysteinemia and total coronary artery occlusion (TCAO). To understand the risk factors for TCAO, we investigated the potential relationship between hyperhomocysteinemia and TCAO, and the interactions between cardiovascular risk factors and hyperhomocysteinemia.

Methods: A total of 890 adult patients from Southwest China participated in this cross-sectional study between February 2018 and February 2021.

Nonsteroidal anti-inflammatory drug monitoring in serum: a Tb-MOF-based luminescent mixed matrix membrane detector with high sensitivity and reliability.

The identification of drugs or biomolecules for public health monitoring requires facile analytical technologies with excellent sensitivity, portability and reliability. In the past decades, different sensing materials have inspired the development of various bioanalytical strategies. However, sensing platforms based on powder materials are not suitable for medical diagnosis, which limits further exploration and application of biosensors.

Ligand-regulated three-photon AIE properties of manganese(II) complexes for photodynamic therapy.

Owing to the advantages of deeper penetration depth and lower biological damage, multi-photon AIE probes are widely used in the field of multi-photon therapy. We have developed a series of carbazole terpyridine manganese(II) complexes (MD1-MD3) that are promising as aggregation-induced emission (AIE) photosensitizers (PSs). MD1-MD3 exhibit excellent three-photon AIE properties in DMSO/HO solution.

Mechanosynthesis and photophysics of colour-tunable photoluminescent group 13 metal complexes with sterically demanding salen and salophen ligands.

A series of four photoluminescent Al and In complexes were synthesised using an environmentally-benign mechanosynthesis strategy. Sterically crowded 3,5-di--butyl functionalised salophen and salen ligands and their respective complexes have been synthesised in the solid-state and fully characterised. Subsequent photophysics and electrochemistry studies of the resulting complexes suggest that these new group 13 complexes can be viable alternatives to traditional photoluminescent complexes based on expensive and low abundant noble metals.

Trophinin-associated protein expression correlates with shorter survival of patients with glioma: a study based on multiple data fusion analysis.

Background: Trophinin-associated protein (TROAP) mediates embryonic transfer, regulates microtubules, and is associated with the biological behavior of various cancers. However, there is limited information on the role of TROAP in glioma.

Methods And Results: We obtained clinical information on 1948 patients with glioma from The Cancer Genome Atlas, Gene Expression Omnibus and the Chinese Glioma Genome Atlas.

Advantages of McKeown minimally invasive oesophagectomy for the treatment of oesophageal cancer: propensity score matching analysis of 169 cases.

Background: Oesophagectomy, the gold standard for oesophageal cancer treatment, causes significantly high morbidity and mortality. McKeown minimally invasive oesophagectomy (MIE) is preferred for treating oesophageal malignancies; however, limited studies with large sample sizes focusing on the surgical and oncological outcomes of this procedure have been reported. We aimed to compare the clinical safety and efficacy of McKeown MIE with those of open oesophagectomy (OE).

Ultralow-Threshold and High-Quality Whispering-Gallery-Mode Lasing from Colloidal Core/Hybrid-Shell Quantum Wells.

The realization of efficient on-chip microlasers with scalable fabrication, ultralow threshold, and stable single-frequency operation is always desired for a wide range of miniaturized photonic systems. Herein, an effective way to fabricate nanostructures- whispering-gallery-mode (WGM) lasers by drop-casting CdSe/CdS@Cd Zn S core/buffer-shell@graded-shell nanoplatelets (NPLs) dispersion onto silica microspheres is presented. Benefiting from the excellent gain properties from the interface engineered core/hybrid shell NPLs and high-quality factor WGM resonator from excellent optical field confinement, the proposed room-temperature NPLs-WGM microlasers show a record-low lasing threshold of 3.

Low-impedance high-power pulsed generator based on forming line with built-in Tesla transformer.

In order to meet the application needs of gyromagnetic nonlinear transmission lines, a pulsed power generator is required to output short duration pulses with a fast rising edge in high repetitive-rate mode. In this paper, a low-impedance high-power pulsed generator based on the forming line with a built-in Tesla transformer is explored and developed. The generator includes a 14 Ω coaxial forming line, a SF/N gas switch, and a resistive dummy load, which can steadily operate in 100 Hz mode and suits the needs above.

Clinicopathological and prognostic values of PD-L1 expression in oesophageal squamous cell carcinoma: a meta-analysis of 31 studies with 5368 patients.

Several immune checkpoint inhibitors targeting programmed death ligand 1 (PD-L1)/programmed death 1 have successfully improved the prognosis of oesophageal squamous cell carcinoma (ESCC) with approval in certain countries. However, whether the expression of PD-L1 is associated with the degree of benefit is unclear yet and a unified standard of antibody and cut-off value of PD-L1 detection is also lacking. The current meta-analysis then aimed to explore the association between PD-L1 expression and clinicopathological features as well as prognosis in ESCC.

A mild reduction of Co-doped MnO to create abundant oxygen vacancies and active sites for enhanced oxygen evolution reaction.

Efficient and non-precious-metal-based catalysts (e.g., manganese-based oxides) for the oxygen evolution reaction (OER) remain a substantial challenge.

Changes in Muscle Mass in Patients With Renal Transplants Based on Ultrasound: A Prospective Study.

Objectives: This original research aimed to investigate the value of ultrasound (US), including grayscale US and shear wave elastography (SWE), in quantitatively evaluating muscle mass after kidney transplantation.

Methods: A total of 52 patients and 54 healthy control participants were recruited. High-frequency US was used to evaluate the echo intensity and muscle morphologic features.

Green Grinding-Coassembly Engineering toward Intrinsically Luminescent Tetracene in Cocrystals.

Developing an effective and green method toward organic functional cocrystals based on the solubility-mismatched coformers is highly desirable and very important. Herein, we applied a green two-step liquid-assisted-grinding coassembly (LAGC) in fabricating tetracene-octafluoronaphthalene (TC-OFN) cocrystals from solubility-mismatched pairs of tetracene (TC, poorly soluble, 0.2 mg mL) and octafluoronaphthalene (OFN, highly soluble, 0.

Antineoplastic Mitoxantrone Monitor: A Sandwiched Mixed Matrix Membrane (MMM) Based on a Luminescent MOF-Hydrogel Hybrid.

A sandwiched mixed matrix membrane (MMM) based on a metal-organic framework-hydrogel hybrid exhibits eximious performance in the detection of mitoxantrone. Parts per billion-level sensitivity and good selectivity in serum among other analogous antineoplastics have been achieved. This flexible MMM can be used for point-of-care testing drugs in a biological medium.