Publications by authors named "Xiao Li-Zhen"

Article Synopsis
  • Iron-catalyzed method allows for efficient dehydroxyboration of allylic alcohols to create ()-stereoselective allylboronates.
  • The process is effective for a variety of allylic alcohols, particularly those from natural products.
  • A six-membered ring transition state involving allylic alcohols and an iron-boron intermediate plays a crucial role in transferring the boron group, activating the C-OH bond, and ensuring stereoselectivity.
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Objective: To report the diagnosis and treatment of an imported case of schistosomiasis haematobium, including the pathological features of the disease and therapeutic efficacy of praziquantel.

Methods: The data of the patient with schistosomiasis haematobium were collected, and the pathological features of the bladder tissue were observed under a microscope. More-over, the patient was treated with praziquantel, and his urine was collected before and after the treatment.

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Article Synopsis
  • A series of new arylidene N-alkoxydiketopiperazines were created using specific chemical processes, leading to a focus on their properties and effectiveness.
  • The study highlighted potential mechanisms for how these compounds could rearrange and fragment, supported by crystal structure analysis.
  • Several compounds showed strong antitumor activity, particularly against the enzyme caspase-3, with certain variants demonstrating promising selectivity and potency in low micromolar concentrations.
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A series of open-chain analogs of cyclic peptides was designed and synthesized using sansalvamide A as a model compound. All compounds exhibited low antitumor activity. Furthermore, the evaluation of their inhibitory potency toward IMPDH, SHP2, ACHE, proteasome, MAGL, and cathepsin B showed that all of the compounds were potent against protein tyrosine phosphatase Shp2.

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Article Synopsis
  • The compound C(10)H(14)NO(4) (+)·Cl(-) features a benzene ring that is tilted at an angle of 64.68 degrees from the attached methyl-amino-propano-ate unit.
  • A strong hydrogen bond occurs within the molecule, specifically between the oxygen and hydrogen atoms (O-H⋯O).
  • In the crystal structure, various types of hydrogen bonds (O-H⋯O, N-H⋯Cl, O-H⋯Cl) along with weaker interactions (C-H⋯O) create a three-dimensional network of molecules.
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In the title compound, C(22)H(20)N(+)·Cl(-), the anthracene system makes a dihedral angle of 72.65 (4)° with the benzene ring. The C-N-C-C torsion angles in the chain connecting the benzene ring and anthracene system are 52.

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In the title compound, C(15)H(20)O(7), the benzene ring makes dihedral angles of 69.17 (5) and 80.81 (4)° with the two side chains of malonate.

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In the title compound, C(15)H(15)NO(4), the quinoline ring system and one of the malonate side chains are essentially coplanar (r.m.s.

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In the title compound, C(20)H(22)N(2)O(5), the central 1,3,4-oxadiazole ring is essentially planar [r.m.s.

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Article Synopsis
  • The compound C(25)H(23)N(3)O(5)S contains a central 1,3,4-oxadiazole ring.
  • The ring forms specific angles with three attached benzene rings, which are 35.05°, 23.68°, and 82.55°.
  • The crystal structure features weak hydrogen bonds that connect the molecules into a continuous network.
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In the title compound, C(25)H(22)N(4)O(4), the central benzene ring, makes dihedral angles of 74.35 (6), 17.01 (8) and 62.

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In the title compound, C(24)H(20)BrN(3)O(4)S, the central benzene ring makes dihedral angles of 17.13 (13), 39.83 (13) and 58.

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In the title compound, C(20)H(15)ClN(4)O(7)S·4CH(3)COOH, the central o-vanillin group makes dihedral angles of 9.50 (11) and 42.86 (7)°, respectively, with its attached pyridine and nitro-benzene rings.

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