Publications by authors named "Xiao Jun Yang"

Problem: Endometriosis (EM) is known as a common estrogen-dependent chronic inflammatory disease. Elevated levels of Forkhead box L2 (FOXL2) have been observed in uterine diseases, including EM. However, the molecular mechanism of FOXL2 in EM needs to be further illustrated.

View Article and Find Full Text PDF

An effective and economical copper-catalyzed approach for the synthesis of phosphorylated 1-isochromenes is reported. This method is the first example of focus on ketone phosphonylation to establish a C-P bond and 6-- cyclization to construct a C-O bond between aryl- and alkyl-substituted alkynylketones and H-phosphinate esters, H-phosphites, and H-phosphine oxides, resulting in chemo- and regioselective phosphorylated 1-isochromenes with moderate to excellent yields under smooth reaction conditions.

View Article and Find Full Text PDF

Rising incidence of a complicated disorder with a multifarious etiology is acute pancreatitis. Growing numbers of cases of acute pancreatitis are linked to obesity, hyperlipidemia, hyperglycemia, hypertension, and other metabolic diseases. Trends driven by better living standards and unhealthy lifestyle choices both in China and abroad.

View Article and Find Full Text PDF
Article Synopsis
  • A review of the Amida genus from China includes a total of thirteen species, with four being newly discovered.
  • The new species are Amida sagittata, Amida longifolia, Amida motuensis, and Amida nanlingiensis.
  • The document provides detailed descriptions, illustrations for each species, a distribution map, and an identification key for easier recognition.
View Article and Find Full Text PDF
Article Synopsis
  • Innate immune responses are essential for maintaining balance in the body, and they are triggered by specific receptors on immune cells.
  • CD209 is one of these receptors found on macrophages and dendritic cells that is key for immune functions, but its effect on certain immune cells is not well understood.
  • In a study, researchers identified three genes in zebrafish that are similar to human CD209 and found that one of them regulates macrophage activity and impacts neutrophil development, highlighting its potential role in innate immunity.
View Article and Find Full Text PDF

Glial cell line-derived neurotrophic factor (GDNF) has been demonstrated to promote the development of liver fibrosis, but its role in intestinal fibrosis is unknown. Macrophage-to-myofibroblast transition (MMT) is an important pathway contributing to fibrosis diseases. However, whether MMT cells, characterized by co-expressing both macrophage (CD68 or F4/80) and myofibroblast (α-SMA) markers, occurs in intestinal fibrosis remain to be addressed.

View Article and Find Full Text PDF

Poultry, a vital economic animal, provide a high-quality protein source for human nutrition. Over the past decade, the poultry industry has witnessed substantial achievements in breeding, precision feeding, and welfare farming. However, there are still many challenges restricting the sustainable development of the poultry industry.

View Article and Find Full Text PDF
Article Synopsis
  • Graph Neural Networks (GNNs) are increasingly used in recommender systems, and integrating contrastive learning enhances their ability to interpret knowledge effectively.
  • The proposed MVKC model utilizes hierarchical and augmented views to improve the learning process in GNNs, enabling better extraction of meaningful features from knowledge and interaction graphs.
  • Experimental results indicate that the MVKC model significantly outperforms existing methods, showcasing its effectiveness in addressing challenges like sparsity, noise reduction, and robustness in recommendations.
View Article and Find Full Text PDF
Article Synopsis
  • The Xiao Jiang River is vital for ecological restoration and agricultural water use in the upper Yangtze River, influencing both water quality and ecosystem health.
  • In 2022, plankton surveys using environmental DNA technology revealed the presence of 881 plankton species, highlighting significant diversity and variations between dry and wet periods.
  • Findings indicated that Ciliophora, Chlorophyta, and Bacillariophyta were dominant, suggesting oligotrophic to mesotrophic water quality, while analyses showed differing plankton community structures linked to environmental conditions.
View Article and Find Full Text PDF
Article Synopsis
  • Salt sensitivity of blood pressure (SSBP) is a key factor in understanding hypertension and cardiovascular risks, but its genetic components are not well-defined. This study aimed to identify relevant genes and create a risk evaluation model for SSBP.
  • Through a genome-wide association study and transcriptome-wide analysis of 12 tissues, researchers identified 2,605 genes connected to SSBP, with 69 showing significant expression differences. The analysis revealed that these genes are mainly involved in metabolic processes.
  • The study developed risk evaluation models based on genetic data, finding that a polygenic risk score with a P-value less than 0.05 was the most effective for predicting SSBP, though combining different scores did
View Article and Find Full Text PDF
Article Synopsis
  • Dysregulation of enhancer transcription and the role of enhancer RNAs (eRNAs) in cancer is explored, aiming to identify genetic factors influencing eRNA expression to better understand cancer mechanisms.! -
  • Researchers conducted a detailed analysis of eRNA quantitative trait loci (eRNAQTLs) in colorectal cancer samples from China, integrating epigenomic and genetic data from over 154 CRC cases to establish the first eRNAQTL profiles.! -
  • A total of 300,112 eRNAQTLs were identified across various cancers, highlighting their connection to cancer risk and potential therapeutic targets, with a specific focus on an eRNAQTL variant (rs3094296-T) that reduces colorectal cancer risk in Chinese
View Article and Find Full Text PDF

Background: The Correa sequence, initiated by (), commonly progresses to gastric cancer through the stage of chronic atrophic gastritis (CAG). Although eradication of only reduces the risk of gastric cancer, it does not eliminate the risk for neoplastic progression. Yiwei Xiaoyu granules (YWXY) are a commonly used composite preparation in Chinese clinics.

View Article and Find Full Text PDF

Background: Ulcerative colitis (UC) and systemic lupus erythematosus (SLE) are both systemic immunoreactive diseases, and their pathogenesis depends on the interaction between genes and environmental factors. There are no reports of UC with SLE in China, but six cases of SLE with UC have been reported in China. The combination of these two diseases has distinct effects on the pathogenesis of both diseases.

View Article and Find Full Text PDF

The extensive and repeated application of chemical fungicides results in the rapid development of fungicide resistance. Novel antifungal pesticides are urgently required. Natural products have been considered precious sources of pesticides.

View Article and Find Full Text PDF
Article Synopsis
  • Laying hens, particularly egg-type chicks, are at risk of heart issues due to dietary selenium (Se) insufficiency, which has been shown to affect cardiac health in broiler chickens.
  • In this study, White Leghorn chicks were fed diets either lacking in Se or supplemented with it, revealing significant differences in heart health and body weight, with Se-deficient chicks showing signs of cardiac inflammation and reduced selenoprotein expression.
  • The research indicates that a lack of selenium leads to increased inflammatory markers and oxidative stress in the hearts of these chicks, highlighting the critical role of Se in maintaining cardiac health early in life.
View Article and Find Full Text PDF
Article Synopsis
  • Minimally invasive surgery uses advanced tools to treat issues in the body with smaller incisions, achieving similar outcomes to traditional surgery while reducing trauma and recovery time.
  • It is particularly beneficial for gastric cancer patients, offering options like endoscopic mucosal resection and laparoscopic techniques, which minimize blood loss and psychological stress.
  • Innovations in these techniques, such as band-assisted EMR and closed LECS, enhance precision and effectiveness for various stages of early gastric cancer treatment.
View Article and Find Full Text PDF

Aim Of The Study: To evaluate the therapeutic effect of SYNC in diarrhea irritable bowel syndrome (IBS-D) and explore its underlying mechanism through transcriptomic sequencing (RNA-Seq).

Materials And Methods: A rat model of IBS-D was constructed to elucidate the effects of SYNC. Abdominal withdrawal reflex (AWR), fecal water content (FWC), and recording body weight were calculated to assess visceral sensitivity in rats.

View Article and Find Full Text PDF

Arthrobotrys flagrans, a nematode-eating fungus, is an effective component of animal parasitic nematode biocontrol agents. In the dried formulation, the majority of spores are in an endogenous dormant state. This study focuses on dormant chlamydospore and nondormant chlamydospore of A.

View Article and Find Full Text PDF

Background: The aim of the study was to investigate whether the expression of CD27CD38 in interferon (IFN)-γCD4 T cells stimulated by the specific antigen early secreted antigenic target-6 (ESAT-6)/culture filter protein-10 (CFP-10) could be a potential new therapeutic evaluation indicator for anti-tuberculosis (TB) treatment.

Methods: Newly diagnosed active pulmonary TB patients, latent TB infection (LTBI) and healthy controls were enrolled from January 2021 to December 2021. PTB patients were treated by standard anti-TB regimen 2HREZ/4HR (2 months of isoniazid (H), rifampin (R), ethambutol (E), and pyrazinamide (Z) followed by 4 months of isoniazid (H) and rifampin (R)).

View Article and Find Full Text PDF
Article Synopsis
  • Gastric cancer has a high mortality rate, and nintedanib has demonstrated effectiveness in reducing tumor cell growth and promoting cell death in gastric cancer cells, although its precise mechanism of action remains unclear.
  • A study utilized high-throughput proteomics to investigate the effects of nintedanib on AGS gastric cancer cells, revealing 845 proteins with altered expression in response to nintedanib treatment, indicating significant biochemical changes.
  • Bioinformatics analysis of these proteins highlighted critical metabolic pathways and identified key proteins, suggesting potential targets and mechanisms through which nintedanib exerts its effects, ultimately showing promise in inhibiting tumor progression.
View Article and Find Full Text PDF

The activation of toll-like receptor 3 (TLR3) has been reported to attenuate astrocytes injury in central nervous system, but its effect on enteric glial cells (EGCs) remains unknown. Here, we confirmed that the residence of EGCs was regulated by TLR3 agonist (polyinosinic-polycytidylic acid, PIC) or TLR3/dsRNA complex inhibitor in dextran sulfate sodium (DSS)-induced mice. In vitro, TLR3 signaling prevented apoptosis in EGCs and drove the secretion of EGCs-derived glial cell line-derived neurotrophic factor, 15-hydroxyeicosatetraenoic acid and S-nitrosoglutathione.

View Article and Find Full Text PDF

Dysregulated thioredoxin-interacting protein (TXNIP) has been observed in women with gestational diabetes mellitus (GDM), but the specific role of TXNIP in GDM and the underlying mechanism remain unclear. HTR-8/SVneo cells were treated with high glucose to mimic the injured trophoblasts of GDM. In vitro, TXNIP knockdown was performed by siRNA.

View Article and Find Full Text PDF