Five-year complete remission of super-giant hepatocellular carcinoma with hepatectomy followed by sorafenib plus camrelizumab: A case report.

Background: Cirrhotic patients with super-giant hepatocellular carcinoma (HCC) and portal vein invasion generally have a poor prognosis. This paper presents a patient with super-giant HCC and portal vein invasion, who underwent hepatectomy followed by a combination of sorafenib and camrelizumab, resulting in complete remission (CR) for 5 years.

Case Summary: A 40-year-old male with compensated hepatitis B-related cirrhosis was diagnosed with HCC, Barcelona Clinic Liver Cancer stage C.

Efficacy of Modified Electroconvulsive Therapy in Treatment-Resistant Schizophrenia.

Objective: The aim of the study was to investigate the therapeutic effects of modified electroconvulsive therapy (MECT) in combination with risperidone tablets and psychotherapy in the treatment of patients with treatment-resistant schizophrenia (TRS).

Methods: Patients with TRS admitted to the psychiatric department of our hospital between January 2018 and December 2019 were selected as study participants. They were randomly divided into a control group and a study group, with the control group receiving risperidone tablets and psychotherapy, and the study group undergoing MECT as well as the control group treatment.

Cost-Effectiveness Analysis of Inclisiran for the Treatment of Primary Hypercholesterolemia or Mixed Dyslipidemia in Singapore.

Objectives: This analysis evaluated the cost-effectiveness of inclisiran plus standard of care (SoC; comprising statins, ezetimibe, and fenofibrate) in primary hypercholesterolemia or mixed dyslipidemia from a Singapore healthcare system perspective. Inclisiran + SoC was separately compared with SoC, alirocumab + SoC, and evolocumab + SoC.

Methods: A lifetime Markov model in the United Kingdom (UK) was adapted to the Singapore setting.

The return of stagnant slab recorded by intraplate volcanism.

Subducted plates often stagnate in the mantle transition zone (MTZ), and the fate of the stagnant slabs is still debatable. They may sink into the lower mantle, or remain partially trapped in the MTZ, but it is uncertain whether they can return to the upper mantle. We report geochemical evidence of late-Miocene (~6 Ma) basalts from, and upper mantle seismic evidence beneath Shuangyashan, an area above the slab tear of the stagnant Pacific plate in eastern Asia, to show how the slab returns to the upper mantle from the MTZ.

[Immediate metatarsal lengthening for congenital brachymetatarsia].

Objective: To explore clinical efficacy of congenital brachymetatarsia with immediate metatarsal lengthening.

Methods: From March 2015 to December 2020, 7 patients with brachymetatarsia were treated, including 6 females and 1 male;aged range from 18 to 30 years old;there were 5 patients with metatarsal microsomia on one foot, 2 patients with metatarsal microsomia on the first and fourth right foot, and immediate extension of metatarsal microsomia on the first and fourth right foot;two patients were short metatarsal bones of both feet. The length of short metatarsal bone, length of normal metatarsal bone, distance of short metatarsal bone and healing of bone graft were observed before and 12 months after operation.

Ultrabroadband Visible-Near-Infrared Phosphor CaYMgGeO:Ce/Cr and Its Temperature Sensing.

With the wide application of phosphor conversion light-emitting diode (pc-LED) in nondestructive testing, spectral illumination, near-infrared (NIR) spectroscopy, agricultural medical care, and other fields, the ultrabroadband visible-NIR tunable emission phosphor is considered as the most promising fluorescent material. In this paper, Ce/Cr single-doped and codoped CaYMgGeO phosphors were successfully prepared by using the high-temperature solid-state method. Ce and Cr codoped phosphors show ultrabroadband visible-NIR emission from 480 to 900 nm with two emission peaks at visible 556 nm and infrared 758 nm.

[Non-targeted Screening and Ecological Risk Assessment of Emerging Contaminants in Beijiang Drinking Water Source of the Pearl River Delta].

To investigate the spatial and temporal distribution characteristics and assess the ecological risks associated with emerging contaminants （ECs） in the Beijiang drinking water source, non-targeted screening was conducted using the ultra-high performance liquid chromatography-mass spectrometry technique （UPLC-MS） for one year （June 2022 to May 2023）. This study also involved the quantitative detection of eight typical ECs. The results showed that through the non-targeted screening, a total of 346 pollutants were identified, with industrial materials, pharmaceuticals, and pesticides being the predominant pollutants, collectively accounting for 88.

Hemoadsorption during cardiopulmonary bypass to absorb plasma-free hemoglobin in patients with acute type a aortic dissection: A randomized controlled trial.

Aims: This study aimed to investigate the effect of hemoadsorption (HA) on plasma-free hemoglobin (pfHb) levels during cardiopulmonary bypass (CPB) and the clinical outcomes in patients with acute type A aortic dissection (ATAAD).

Methods: In this single-center randomized trial, patients were assigned to either a group using the HA380 device or a control group without it. The primary outcome was changes in pfHb levels during CPB and within the first 48 hours after surgery.

Tetraphenylethene-Based Ni-Pyrazolate Metal-Organic Framework for Photoredox/Nickel Dual Catalysis of C-S Cross-Coupling.

As a prototypical aggregation-induced emission luminogen (AIEgen), the tetraphenylethene (TPE) moiety has been judiciously modified as organic linkers for constructing various functional metal-organic frameworks (MOFs). However, these AIEgen-based MOFs have rarely received research attention in photocatalytic applications due to their limited stability in harsh reaction conditions. In this work, we report a robust Ni-pyrazolate-based MOF (denoted as TPE4Pz-Ni) under the guidance of reticular chemistry, which is assembled by an AIE-active tetratopic linker of 1,1,2,2-tetrakis(4-(1-pyrazol-4-yl)phenyl)ethane (H-TPE4Pz) with a 12-connected Ni-cluster of [Ni(OH)(HO)Pz] (Pz = pyrazolate) in a (4,12)-connected -a topological network.

Deep-trap ultraviolet persistent phosphor for advanced optical storage application in bright environments.

Extensive research has been conducted on visible-light and longer-wavelength infrared-light storage phosphors, which are utilized as promising rewritable memory media for optical information storage applications in dark environments. However, storage phosphors emitting in the deep ultraviolet spectral region (200-300 nm) are relatively lacking. Here, we report an appealing deep-trap ultraviolet storage phosphor, ScBO:Bi, which exhibits an ultra-narrowband light emission centered at 299 nm with a full width at half maximum (FWHM) of 0.

A case report on congenital hypothyroidism and alpha thalassemia in children with anemia and muscle damage as the main manifestation.

Rationale: This study reports the first case of congenital hypothyroidism (CH) and alpha thalassemia in a child in China, with anemia and muscle damage as the main manifestations. Analyzing and studying this case is of great significance in reducing missed and misdiagnosed CH and will provide a clinical strategy for treating these patients.

Patient Concerns: Child, female, 2 years and 7 months old, the child appeared dispirited, had poor appetite, shallow complexion, reduced activities with anemia, elevated muscle enzymes, height, and growth retardation.

Concept for power scaling by harmonic beam coaxial combination in an intra-cavity frequency doubling laser.

A new method of harmonic beam coaxial combination (HBCC) from two intra-cavity frequency doubling branches was demonstrated. Firstly, two identical nanosecond (ns) 532 nm green lasers with high power and good beam quality were created. Each green laser was constructed of an intra-cavity frequency doubling branch based on a laser diode (LD) end-pumped acousto-optical (AO) Q-switched 1064 nm Nd:YVO laser in a LiBO (LBO) nonlinear crystal.

Potential applications of single-incision laparoscopic totally preperitoneal hernioplasty.

Background: The totally preperitoneal (TPP) approach is a new concept that was recently introduced. Although the TPP approach combined with single-incision laparoscopic hernia repair has its own advantages, there is little evidence reflecting the characteristics and feasibility of either approach.

Aim: To analyze the potential applications of single-incision laparoscopic TPP (SIL-TPP) inguinal hernia hernioplasty for the treatment of inguinal hernias.

Significance of Ribonucleoside-diphosphate Reductase Subunit M2 in Lung Adenocarcinoma.

Introduction: The Ribonucleoside-diphosphate Reductase subunit M2 (RRM2) is known to be overexpressed in various cancers, though its specific functional implications remain unclear. This aims to elucidate the role of RRM2 in the progression of Lung Adenocarcinoma (LUAD) by exploring its involvement and potential impact.

Methods: RRM2 data were sourced from multiple databases to assess its diagnostic and prognostic significance in LUAD.

Effects of electroacupuncture combined with paliperidone palmitate long-acting injection on withdrawal symptoms and neurotransmitters in methamphetamine addicts.

Objective: To investigate the effects of electroacupuncture combined with paliperidone palmitate long-acting injection (PP-LAI) on withdrawal symptoms and neurotransmitters in methamphetamine (MA) addicts.

Materials And Methods: A total of 109 methamphetamine addicts, who were treated in the hospital from October 2021 to October 2022, were selected. According to the random number table, the patients were divided into the study group (n=54) and the control group (n=55), in which the control group was treated with PP-LAI and the study group was treated with electroacupuncture on the basis of the control group; the methamphetamine withdrawal symptom score scale was used to assess the therapeutic effect before treatment and within 12 months after treatment; the changes of brain neurotransmitters dopamine, γ-aminobutyric acid, serotonin, acetylcholine values were compared between the two groups.

Response Surface Methodology Optimization of Resistance Welding Process for Unidirectional Carbon Fiber/PPS Composites.

The use of thermoplastic composites (TPCs) as one of the lightweight solutions will inevitably encounter problems in connection. Resistance welding has the characteristics of high strength, simplicity, and high reliability, and is considered a very potential hot-melt connection technology. The resistance welding technology of unidirectional carbon fiber-reinforced polyphenylene sulfide composites (UCF/PPS) was systematically studied.

Optical Information Transmission and Multimode Fluorescence Anticounterfeiting of CaMgGeO:Mn.

Multimode emission of Mn for multimode fluorescence anticounterfeiting is achieved by cation site and interstitial occupancy in CaMgGeO. The rings in CaMgGeO have a significant distortion for Mn ions to enter the ring interstitials with a luminescence center at 665 nm, which is supported by XRD refinement results and first-principles calculations. The interstitial Mn ion has good thermal stability with an activation energy of 0.

Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma.

Objective: Lung squamous cell carcinoma (LUSC) is associated with a low survival rate. Evidence suggests that bone morphogenetic proteins (BMPs) and their receptors (BMPRs) play crucial roles in tumorigenesis and progression. However, a comprehensive analysis of their role in LUSC is lacking.

[Evaluation and spatial-temporal variations of ecological comprehensive index along the Yellow River of Shanxi Province, China].

Ecological comprehensive index can quantitatively and visually analyze the temporal and spatial variations of ecological environment quality in a region. Based on the five indices of fractional vegetation coverage, leaf area index, total primary productivity, land surface temperature and wetness obtained by MODIS satellite data in 2001, 2005, 2010, 2015 and 2020, and coupled the comprehensive quality of the eco-environment (), we analyzed the temporal and spatial variations of ecological quality along the Yellow River of Shanxi Province from 2001 to 2020 by using the principal component analysis and spatial autocorrelation method. The results showed that the mean value of in the study area increased from 0.

Constricted posterior fourchette deformities: Definition, classification and surgical treatment.

Background: Labiaplasty is one of the top cosmetic procedures patients are seeking in the past two years. However, treatment of disease in posterior fourchette caused by various etiological factors was less investigated and neglected.

Methods: Three types of posterior fourchette deformity were proposed: (1) Redundant posterior fourchette, (2) Relaxed posterior fourchette, and (3) Constricted posterior fourchette.