Histone deacetylase inhibitors promote epithelial-mesenchymal transition in Hepatocellular Carcinoma AMPK-FOXO1-ULK1 signaling axis-mediated autophagy.

Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related deaths globally because of high metastasis and recurrence rates. Elucidating the molecular mechanisms of HCC recurrence and metastasis and developing effective targeted therapies are expected to improve patient survival. The promising anti-cancer agents for the treatment of hematological malignancies, histone deacetylase inhibitors (HDIs), have limited effects against epithelial cell-derived cancers, including HCC, the mechanisms involved have not been elucidated.

Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy.

Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles. It can promote or suppress tumor development, so it is a "double-edged sword" in tumors that depends on the cell and tissue types and the stages of tumor. The epithelial-mesenchymal transition (EMT) is a complex biological trans-differentiation process that allows epithelial cells to transiently obtain mesenchymal features, including motility and metastatic potential.

The relationship between autophagy and the immune system and its applications for tumor immunotherapy.

Autophagy is a genetically well-controlled cellular process that is tightly controlled by a set of core genes, including the family of autophagy-related genes (ATG). Autophagy is a "double-edged sword" in tumors. It can promote or suppress tumor development, which depends on the cell and tissue types and the stages of tumor.

[Study on risk assessing indicator system after schistosomiasis transmission interruption in Wuxi City].

Objective: To establish a risk assessing indicator system after the transmission interruption of schistosomiasis in Wuxi City, so as to provide evidences for formulating strategies on schistosomiasis control and prevention.

Methods: A primary risk assessing indicator system was established based on the literature review. Alternative indicators were scored and screened to establish a final indicator system through two rounds of Delphy method and the related normalized weights and combined weights were also calculated.

Repeat HIV Testing and Incident Rates among Individuals Attending Voluntary Counseling and Testing Clinics in Wuxi, China: A Retrospective Study.

Objective: We aimed to elucidate the rates of repeat HIV testing and incident HIV diagnosis, and baseline CD4+ T cell count among individuals attending HIV voluntary counseling and testing (VCT) clinics in Wuxi, China.

Methods: A repeat HIV testing within 12 months was recorded if individuals had their first test with negative results, during 2013-2014 and retested within 12 months. An incident HIV diagnosis was recorded if individuals had their first test with negative results, during 2013-2015 and had a subsequent positive result at any point by the end of 2015.

[Bacterial Community Composition of Activated Sludge from Coking Wastewater].

Coking wastewater is a kind of highly toxic and refractory organic wastewater, and aerobic activated sludge, which is dominated by bacteria, determines the efficiency of coking wastewater treatment. However, the bacterial community structure of activated sludge from coking wastewater has rarely been reported. 454 sequencing technology was applied to investigate the structure and biodiversity of the bacterial community.

[Evaluation on capability of parasitic disease control and prevention among professional and technical personnel in medical and health institutions in Wuxi City].

Objective: To understand the capability of parasitic disease control and prevention among professional and technical personnel in medical and health institutions in Wuxi City, so as to provide the evidence for promoting relative capability building.

Methods: Forty-one professional and technical persons from 22 medical and health institutions received the evaluation through the theoretical knowledge exam and laboratory operation skill assessment.

Results: The average score of theoretical knowledge exam was (76.

[Biodiversity of Thiocyanate-degrading Bacteria in Activated Sludge from Coking Wastewater].

Thiocyanate (SCN) is one of the main sources of COD in coking wastewater, and SCN removal efficiency of the aerobic unit impacts the requirement of discharging standard. Microbial population in the activated sludge plays an important role in SCN removal of coking wastewater treatment. However, the community structure has rarely been reported.

[Survey on infection among key populations in Wuxi City].

Objective: To investigate the prevalence and risk factors of infection among key populations in Wuxi City, Jiangsu Province, so as to provide evidences for developing preventive and control interventions for infection.

Methods: A questionnaire was designed to conduct face-to-face interviews to HIV/AIDS carriers/patients, tumor patients, pregnant women and pet breeders. The blood samples were collected to test anti- IgM and IgG antibodies by using ELISA method.

[Establishment of a monitoring database of historical environments at grass - root level for schistosomiasis prevention based on Google Earth].

Objective: To establish a monitoring database of historical environments at grass-root level for schistosomiasis prevention based on Google Earth (GE), so as to improve the management efficiency of historical environments.

Methods: GE was labeled with the information about the historical environments through adding landmark, path and polygon. Meanwhile, POCO web album was used to storage the practice situation pictures of the environments, which could be imported into GE so that the environments could be monitored dynamically.

[Survey of current situation of schistosomiasis health education in Wuxi City].

Objective: To understand the current situation of schistosomiasis health education in in Wuxi City where schistosomiasis transmission has been interrupted, so as to provide the evidence for formulating the health education strategies.

Methods: Face to face interviews and a professional designed questionnaire were used to collect the information of the current schistosomiasis health education and investigate the awareness of schistosomiasis knowledge in primary and middle schools and in communities.

Results: The total awareness rate of schistosomiasis knowledge was 87.

[Distribution of historical Oncomelania hupensis snail environments and wetland environments in Wuxi City].

Objective: To understand the distribution and characteristics of historical Oncomelania hupensis snail environments and wetland environments in Wuxi City since 1952, so as to provide the evidence for formulating the monitoring strategy after the schistosomiasis transmission was interrupted.

Methods: A cross-sectional survey was conducted to collect the information of historical O. hupensis snail environments and wetland environments.

[Study on the HIV infection status, characteristics of AIDS-related behaviors and risk factors among men attending the sexually transmitted disease clinics].

Objective: To understand the status on AIDS awareness, AIDS-related behaviors, risk factors on HIV infection status among 15 - 90 years or older men at the sexually transmitted disease clinics.

Methods: Data from the 2009 and 2010 national sentinel surveillance system, regarding men attending sexually transmitted disease clinics was collected from Guangdong, Guangxi, Henan, Sichuan, Yunnan and Jiangxi provinces, where the AIDS epidemic among 15 - 90 years or older population was serious. Data was uploaded to National Center for AIDS/STD Control and Prevention (NCAIDS) through the comprehensive AIDS control and prevention information system.

Estimation and projection of the HIV epidemic trend among the migrant population in China.

Objective: The migrant population is a vulnerable group for HIV infection in China. Understanding potential epidemic trends among migrants is critical for developing HIV preventative measures in this population.

Methods: The Estimation and Projection Package (EPP) model was used to process prefecture and county-level surveillance data to generate HIV prevalence and epidemic trends for migrant populations in China.