Deep learning radiomics for the prediction of epidermal growth factor receptor mutation status based on MRI in brain metastasis from lung adenocarcinoma patients.

Background: Early and accurate identification of epidermal growth factor receptor (EGFR) mutation status in non-small cell lung cancer (NSCLC) patients with brain metastases is critical for guiding targeted therapy. This study aimed to develop a deep learning radiomics model utilizing multi-sequence magnetic resonance imaging (MRI) to differentiate between EGFR mutant type (MT) and wild type (WT).

Methods: In this retrospective study, 288 NSCLC patients with confirmed brain metastases were enrolled, including 106 with EGFR MT and 182 with EGFR WT.

Single-cell RNA-seq reveals the immune response of Co-infection with streptococcus pneumoniae after influenza A virus by a lung-on-chip: The molecular structure and mechanism of tight junction protein ZO-1.

Secondary bacterial infection is the main cause of pneumonia after influenza virus infection. This study aims to explore the impact of co-infection of influenza A virus (IAV) and Streptococcus pneumoniae (SP) on lung immune response using a human lung-on-chip model and single-cell RNA sequencing technology, with a focus on the molecular structure and mechanism of action of the tight junction protein ZO-1 in this process. Research and construct a human lung-on-chip model to simulate the microenvironment of the lungs in vivo.

Slice2Mesh: 3D Surface Reconstruction from Sparse Slices of Images for the Left Ventricle.

Cine MRI is a widely used technique to evaluate left ventricular function and motion, as it captures temporal information. However, due to the limited spatial resolution, cine MRI only provides a few sparse scans at regular positions and orientations, which poses challenges for reconstructing dense 3D cardiac structures, which is essential for better understanding the cardiac structure and motion in a dynamic 3D manner. In this study, we propose a novel learning-based 3D cardiac surface reconstruction method, Slice2Mesh, which directly predicts accurate and high-fidelity 3D meshes from sparse slices of cine MRI images under partial supervision of sparse contour points.

Remote sensing-based maize growth process parameters revel the maize yield: a comparison of field- and regional-scale.

The accurate estimation of regional crop yields holds significant importance for optimizing subsequent resource allocation and maximizing economic returns in agriculture. Crop yield can be effectively estimated by assessing the overall growth status through long-term remote sensing observations. However, most previous studies have relied on remote sensing data from one or a few periods for yield estimation, thus lacking a comprehensive description of entire crop growth.

Liver diseases: epidemiology, causes, trends and predictions.

As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles in metabolism, detoxification, and immune response. Various factors including viruses, alcohol, metabolites, toxins, and other pathogenic agents can compromise liver function, leading to acute or chronic injury that may progress to end-stage liver diseases. While sharing common features, liver diseases exhibit distinct pathophysiological, clinical, and therapeutic profiles.

Ultrasmooth Micromilling of Stainless Steel by Ultrashort Pulsed Laser Ablation Using MHz Bursts.

Ultrashort pulsed (USP) laser burst ablation has attracted numerous interests for its great potential in enhancing ablation efficiency and reducing the heat-affected zone. However, little attention has been paid to the influence of burst ablation on the processed surface quality. To fill this research gap, the present study conducts a comprehensive investigation on the surface processing of stainless steel using ultrashort pulsed laser burst ablation.

ADARp110 promotes hepatocellular carcinoma progression via stabilization of CD24 mRNA.

ADAR is highly expressed and correlated with poor prognosis in hepatocellular carcinoma (HCC), yet the role of its constitutive isoform ADARp110 in tumorigenesis remains elusive. We investigated the role of ADARp110 in HCC and underlying mechanisms using clinical samples, a hepatocyte-specific knock-in mouse model, and engineered cell lines. ADARp110 is overexpressed and associated with poor survival in both human and mouse HCC.

The clinical value of local consolidative therapy for oligo-residual disease in PD-1/PD-L1 inhibitors-treated non-small cell lung cancer.

Background: Few real-world studies exist regarding the clinical value of local consolidative therapy (LCT) for oligo-residual disease (ORD) in NSCLC patients treated with immune checkpoint inhibitors. Therefore, we retrospectively evaluated whether LCT could improve the prognosis of NSCL patients with ORD after effective first-line PD-1/PD-L1 inhibitors treatment.

Methods: A total of 132 patients with metastatic NSCLC who had received first-line PD-1/PD-L1inhibitors-based systemic treatment and developed ORD (defined as residual tumors limited to three organs and five lesions) were included.

Root metabolites regulated by FERONIA promote phosphorus-solubilizing rhizobacteria enrichment induced by Arabidopsis thaliana coping with phosphorus deficiency.

The recruitment of the phosphorus-solubilizing rhizobacteria plays an important role in response to phosphorus deficiency. Through the treatments of Arabidopsis thaliana (Col-0) and the FERONIA (FER) functional deficient mutants (fer-4 and fer-5) with the soil suspension in various phosphorus conditions, we discovered that FER could promote phosphorus-solubilizing rhizobacteria enrichment to rescue the defective plant during phosphorus deficiency. The amplicon sequencing data reflected that the phosphorus-solubilizing rhizobacterial genus Alcaligenes was significantly enriched of Col-0 than fer-4 in low phosphorus conditions.

Improving physical and mental health in women with breast cancer undergoing anthracycline-based chemotherapy through wearable device-based aerobic exercise: a randomized controlled trial.

Purpose: Aimed to assess the impact of wearable device-based aerobic exercise on the physical and mental well-being of women with breast cancer (BC) undergoing chemotherapy.

Methods: Forty adult women with BC who underwent anthracycline-based chemotherapy were randomly allocated to the exercise group ( = 21) or the control group ( = 19). Both groups received standard health education and oncology care.

Association between BMI and health-related physical fitness in adolescents with hearing impairment in China: a cross-sectional study.

Background: This cross-sectional study aimed to address a critical gap in the understanding of the association between body mass index (BMI) and physical fitness levels in adolescents with hearing impairment (HI) in China. This study investigated how different BMI levels impact the physical fitness index (PFI) of HI adolescents.

Methods: This study employed a physical fitness test for HI adolescents attending special education schools.

Characterizing and decoding the key odor compounds of Spirulina platensis at different processing stages by sensomics.

Processing is an indispensable technology in the preparation of Spirulina platensis (S. platensis). The key odorants in liquids, muds, and powders from S.

Intravenous thrombolysis versus dual antiplatelet therapy in minor ischemic stroke within the thrombolytic window (TAMIS): a multicenter cohort study.

Intravenous thrombolysis (IVT) and dual antiplatelet therapy (DAPT) have been widely used in minor ischemic stroke (MIS) treatment. However, the clinical outcomes and safety of these two treatments have not been compared within the early thrombolytic time window. Here, we conducted a multicenter, ambispective cohort study involving patients with MIS presenting within 4.

T cell-related circRNA pairs to predict prognosis of patients with esophageal squamous cell carcinoma.

The prognosis for esophageal squamous cell carcinoma (ESCC), a prevalent and aggressive form of cancer, remains poor despite advancements in treatment options. Addressing the gap in comprehensive prognostic information derived from circRNA expression profiles for ESCC, our study aimed to establish a linkage between circRNA expressions and ESCC prognosis. To achieve this, we first developed an optimized prognostic model named T cell-related risk score (TRRS), which integrates T cell-associated features with machine learning algorithms.

Needs of children with neurodevelopmental disorders and medical complexity: Caregiver perspectives.

Background: Caregivers of children with neurodevelopmental disorders and medical complexities (NDD-MC) coordinate care across complex multisectoral systems. Often NDD-MC children have complex behaviors, however there is limited information on coordination needs for families.

Aim: The objective of this mixed methods study was to understand the needs of families with NDD-MC children.

Cxcl10 and Cxcr3 regulate self-renewal and differentiation of hematopoietic stem cells.

Background: The function of hematopoietic stem cells (HSC) is regulated by HSC internal signaling pathways and their microenvironment. Chemokines and chemokine ligands play important roles in the regulation of HSC function. Yet, their functions in HSC are not fully understood.

The effects of exergames for cognitive function in older adults with mild cognitive impairment: a systematic review and metaanalysis.

Purpose: Exergames are an innovative method that can promote neuroplasticity and improve the cognitive abilities of the elderly. This study aimed to compare the effects of single-task and multi-task exergames on the cognitive ability of the elderly with mild cognitive impairment (MCI).

Methods: Computerized literature search was performed using PubMed, Web of Science, EBSCO, Elsevier, ProQuest, China National Knowledge Infrastructure (CNKI), Wanfang and VIP database to identify relevant articles from the establishment of the database from inception to April 1, 2024.

Effects of online mindful self-compassion intervention on negative body image in breast cancer patients: A randomized controlled trail.

Purpose: The incidence of breast cancer patients with negative body image has increased. However, research on interventions that explicitly reduce negative body image among breast cancer patients remains inadequate. The development of more pragmatic interventions is imperative.