Publications by authors named "Xiao J Tong"
Article Synopsis
- Anosognosia, or a lack of awareness of symptoms, is prevalent in Huntington's disease (HD), but researchers have not fully understood its neuroanatomical causes.
- The study utilized MRI data from 570 HD participants to analyze correlations between brain structures and the severity of anosognosia, measured through discrepancies in scores between patients and their caregivers.
- Findings revealed that the volume of the globus pallidus, along with other brain regions, significantly correlates with anosognosia, indicating that neurodegeneration in both cortical and subcortical areas, especially the globus pallidus, plays a crucial role in this condition.
It has been proposed that cerebrospinal fluid (CSF) can enter and leave the retina and optic nerve along perivascular spaces surrounding the central retinal vessels as part of an aquaporin-4 (AQP4) dependent ocular 'glymphatic' system. Here, we injected fluorescent dextrans and antibodies into the CSF of mice at the cisterna magna and measured their distribution in the optic nerve and retina. We found that uptake of dextrans in the perivascular spaces and parenchyma of the optic nerve is highly sensitive to the cisternal injection rate, where high injection rates, in which dextran disperses fully in the sub-arachnoid space, led to uptake along the full length of the optic nerve.
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- - Huntington's disease results from a CAG repeat expansion in the Huntingtin gene, with longer repeats leading to earlier disease onset. The 'CAG Age Product' (CAP) allows for the analysis of individuals with different CAG lengths by plotting age against repeat lengths.
- - Structural MRI studies show that striatal atrophy occurs years before motor symptoms appear, as demonstrated by multicenter studies (PREDICT-HD, TRACK-HD, IMAGE-HD), but the link between different brain region atrophy has been unclear.
- - This study analyzed multiple datasets to examine brain atrophy in relation to CAP, revealing significant degeneration in basal ganglia structures like the caudate and putamen, while other brain regions showed slower decline,
Introduction: Acute appendicitis is the commonest surgical emergency during pregnancy. The aim of this study is to evaluate the outcomes between antibiotic therapy and appendectomy in the management of uncomplicated appendicitis during gestation.
Methods: From January 2015 to April 2019, there were 2174 emergency appendicitis diagnosed in the University of Hong Kong-Shenzhen Hospital.
Photosynthesis can reflect the responses of plants to environmental changes. In this study, photosynthetic light-response curves were measured by the Li-6400XT photosynthetic system in Quercus variabilis and Robinia pseudoacacia plantations in Xiaolangdi Forest Ecosystem Research Station. Photosynthetic light-response curves were fitted by Ye model.
View Article and Find Full Text PDFIn this study, leaf photosynthetic CO-response curves of Quercus variabilis and Robinia pseudoacacia were measured using a Li-6400XT photosynthetic measurement system in the southern foot of the Taihang Mountain, China. The rectangular hyperbola model (RH), nonrectangular hyperbola model (NRH) andYe model (YZP) were used to fit photosynthetic-CO response curves and compare photosynthetic parameters, including the maximum net photosynthetic rate (A), the initial carboxylation rate (η), light respiration rate (R), CO compensation point (CCP) and CO saturation point (CSP). Compared with the NRH and YZP models, A, η, R and CCP obtained by the RH model were higher, and were 59.
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