Publications by authors named "Xiao Hong Liu"
The properties of laryngeal electromyography in the non-paralyzed sides of patients with idiopathic vocal cord paralysis.
Eur Arch Otorhinolaryngol
December 2024
Objective: To evaluate the injuries of the recurrent laryngeal nerve (RLN), superior laryngeal nerve (SLN), and their innervated laryngeal muscles on the non-paralyzed sides in patients with idiopathic vocal cord paralysis (IVCP).
Methods: Eighty-four cases of patients with IVCP were evaluated using stroboscopic laryngoscopy, voice analysis, and laryngeal electromyography(LEMG). Concurrently, twenty-eight cases involving healthy volunteers without vocal cord paralysis were enrolled and examined using LEMG during the same period.
Article Synopsis
- Aggressive primary gastrointestinal non-Hodgkin lymphoma (PGINHL) is a rare type of cancer that often leads to serious gastrointestinal complications (GICs), with a significant portion of patients experiencing these issues.
- A study analyzed 124 aggressive PGINHL cases to compare patients with GICs to those without, identifying risk factors and treatment outcomes through statistical methods like Logistic regression and Kaplan-Meier survival analysis.
- Findings revealed that nearly half of the patients had GICs, with diffuse large B-cell lymphoma being the most common type, and specific risk factors such as the tumor's location in the small intestine and size were important for predicting complications.
Article Synopsis
- - The study aimed to explore how macular microcirculation is related to kidney function in non-diabetic hypertensive patients and whether macular parameters could be used to track kidney health.
- - Researchers analyzed 62 patients, dividing them into those with renal dysfunction and those with normal kidney function, using optical imaging techniques to assess macular microcirculation.
- - Results showed that patients with renal dysfunction had significantly lower measurements of macular microcirculation, suggesting that these parameters could be useful for monitoring kidney function in this group.
Article Synopsis
- Interoception dysfunction significantly influences the onset and progression of major depressive disorder (MDD), while social support and sociability offer protective effects against MDD.
- The study aims to examine how interoception mediates the relationship between social support and sociability, and to understand social support's independent role in enhancing sociability.
- Results indicate that both patient and healthy control groups show a direct positive effect of social support on sociability, with various interoceptive dimensions impacting this relationship indirectly in the context of MDD.
Research progress on physiological processes-based tree-ring width models of Vaganov-Shashkin (VS)and VS-Lite.
Ying Yong Sheng Tai Xue Bao
August 2024
Article Synopsis
- The Vaganov-Shashkin (VS) and VS-Lite models are essential tools for understanding how tree-ring width responds to climate factors, with the VS model focusing on climate reconstruction and cambial activity, while VS-Lite is used for forecasting forest growth trends.
- A review of literature from 2005 to 2023 highlighted the principles, settings, historical development, and various applications of these models in fields like dendroclimatology and forest ecology.
- To improve model accuracy, future research should aim to optimize parameter adjustments, account for multiple environmental influences, and enhance comparisons with other ecological models.
Background: Recent studies have indicated a close relationship between the thickness of epicardial adipose tissue (EAT) and the occurrence as well as persistence of atrial fibrillation (AF). However, the pathogenesis of this association is still in the exploratory stage. The aim of this study is to explore the correlation EAT, as measured by echocardiography, and P-wave dispersion (Pd) in the context of atrial fibrillation.
View Article and Find Full Text PDFBackground: Ischemic stroke remains a major contributor to global mortality and morbidity. This study aims to provide an updated assessment of rates in ischemic stroke prevalence, incidence, mortality, and disability-adjusted life-years (DALYs) from 1990 to 2021, specifically focusing on including prevalence investigation alongside other measures. The analysis is stratified by sex, age, and socio-demographic index (SDI) at global, regional, and national levels.
View Article and Find Full Text PDFArticle Synopsis
- Intravenous infusion can lead to medication errors, and improving nursing practices may reduce these adverse events in pediatric patients.
- A study analyzed data from 130 children receiving infusions, comparing traditional nursing care to enhanced nursing interventions over one year.
- Results showed that the observation group had significantly lower rates of adverse events, higher compliance, and greater family satisfaction compared to the control group, indicating that improved nursing measures are effective.
Article Synopsis
- * Researchers identified MoPyr4, a DHOase homolog in M. oryzae, and found that deleting this gene impaired fungal growth, virulence, and autophagy processes.
- * MoPyr4 is crucial for UMP biosynthesis and affects multiple signaling pathways related to stress response and pathogenicity, interacting with other proteins involved in autophagy and MAPK signaling pathways.
Introduction: Most COVID-19 survivors are troubled with chronic persistent symptoms, which have currently no definitive treatments. Bufei Huoxue (BFHX) capsule exerts clinical benefit, while the material basis and molecular mechanism remain unclear.
Aim: The study aimed to elucidate the protective mechanisms of BFHX capsules against COVID-19 convalescence.
Article Synopsis
- There's a pressing need for a safe and effective oral treatment for high-risk Acute Promyelocytic Leukemia (APL) during the COVID-19 pandemic.
- In a study of 60 high-risk APL patients, those receiving oral etoposide (VP16) along with all-trans retinoic acid (ATRA) and oral arsenic (RIF) achieved identical remission rates compared to those using intravenous chemotherapy.
- The results showed that the completely oral treatment regimen is not only convenient but also maintains high rates of complete hematological remission and overall survival, making it a promising option for these patients.
Article Synopsis
- - Csn5 is part of the COP9 signalosome and is vital for controlling how pathogenic fungi, like Magnaporthe oryzae, manage autophagy and their ability to cause infection.
- - Researchers found that knocking out Csn5 leads to increased autophagy and a decrease in fungal pathogenicity due to overubiquitination and degradation of a key protein, MoTor, involved in the autophagy process.
- - The study also identified that MoCsn5 interacts with MoAtg6, and through a specific type of ubiquitination (K48), it regulates the levels of MoAtg6, affecting autophagic activity and thus impacting the overall growth and pathogenicity of the fungus
Article Synopsis
- This research investigates how combining semen coicis extract with PD-1 inhibitors can enhance anti-tumor effects, particularly focusing on non-small cell lung cancer (NSCLC).
- The study utilized various databases to identify active components of semen coicis and their target genes, constructing a protein interaction network to understand the mechanisms involved.
- Results showed that the main active components of semen coicis inhibit A549 NSCLC cells effectively, with enhanced effects when paired with PD-1 inhibitors, suggesting that the PI3K-AKT-mTOR pathway plays a significant role in their combined anti-tumor action.
Article Synopsis
- Electrochemical CO transformation is a promising approach to convert renewable energy into storable chemicals while reducing greenhouse gas emissions.
- Metal-nitrogen-carbon (M-N-C) single atom catalysts (SAC) show potential for this process, but achieving both high catalytic activity and product selectivity is challenging.
- This study combines density functional theory (DFT) and machine learning (ML) to rapidly identify effective SACs, resulting in the selection of 33 candidates with optimal performance, including Mn-NC, Pt-NC, and Au-NC, to enhance CO reduction efficiency.
Article Synopsis
- This study investigates the impact of dexmedetomidine (DEX) as a local anesthetic adjuvant on postoperative delirium (POD) in elderly patients after elective hip surgery.
- A total of 120 patients were divided into two groups: one receiving DEX with ropivacaine (Y group) and the other receiving only ropivacaine (R group).
- Results showed that the Y group had lower rates of POD, required less remedial analgesia, and experienced better postoperative inflammatory markers, although they had a higher incidence of bradycardia compared to the R group.
Article Synopsis
- Depression is connected to an imbalance in the autonomic nervous system, and the effects of sleep deprivation and vagus nerve stimulation on mental health are not completely understood.
- A study found shorter sleep duration linked to higher depression levels and lower heart rate variability (HRV), while a mouse model showed that vagus nerve stimulation improved the negative effects of sleep deprivation.
- The findings suggest that using vagus nerve stimulation could help prevent depression in people with inadequate sleep by improving autonomic nervous system function and overall emotional well-being.
A comparative analysis of laryngeal nerve damage in patients with idiopathic vocal cord paralysis exhibiting different paralytic sides.
Laryngoscope Investig Otolaryngol
February 2024
Article Synopsis
- The study aimed to evaluate nerve damage in patients with idiopathic vocal cord paralysis (IVCP) by comparing left-sided and right-sided cases.
- A total of 84 patients were analyzed using various methods like laryngoscopy and electromagnetic tests, focusing on differences based on the side of paralysis and disease duration.
- Results showed no significant differences in voice indicators or nerve function between the sides, indicating similar levels of damage in both left and right paralysis when accounting for disease duration.*
The effectiveness of various treatment approaches for laryngeal contact granulomas.
Eur Arch Otorhinolaryngol
April 2024
Article Synopsis
- The study aimed to evaluate and compare the effectiveness of different treatments for laryngeal contact granulomas (LCG) by analyzing 45 patients from Xi'an Jiaotong University.
- Three treatment groups were analyzed: acid suppression alone, hormone injection with acid suppression, and surgery with acid suppression, focusing on treatment effectiveness and healing time.
- Results showed that hormone injection combined with acid suppression significantly improved healing rates and reduced healing time compared to acid suppression alone, while granuloma size was larger in patients with hoarseness.
Article Synopsis
- The cell cycle is crucial for differentiation in plant pathogenic fungi, particularly in the rice blast fungus, Magnaporthe oryzae, where gene MoSwe1 is identified as a key regulator.
- MoSwe1 influences cell wall integrity (CWI) signaling by targeting the MAP kinase MoMps1, and mutations in MoSwe1 lead to abnormal CWI functions and cell cycle arrest.
- The study also indicates that MoSwe1 facilitates autophagy through interactions with core autophagy proteins, impacting mutant fungal morphology and functions critical for pathogen development and virulence.
Article Synopsis
- Mitochondria play key roles in various cellular processes, including energy production and cell growth, with a specific focus on the protein mitoguardin (Miga) and its importance in ovarian development.* -
- The study found that MIGA1 and MIGA2 promote ovarian granulosa cell proliferation and influence the activity of the protein YAP1 through the Hippo signaling pathway, particularly noting the effects of MIGA2.* -
- MIGA2's regulation of YAP1 activity and the interaction with lysophosphatidic acid (LPA) and AKT activity may shed light on reproductive endocrine diseases like polycystic ovary syndrome (PCOS).*
Article Synopsis
- Rice blast disease negatively impacts crop productivity and is caused by specific pathogens that produce small secreted proteins called effectors.
- These effectors interact with host cell receptors to trigger signaling pathways that affect processes like cell growth and death.
- The review summarizes recent findings on the identification and function of effectors, while also outlining future research challenges and directions.
Article Synopsis
- * In plants, they are vital for cell development and stress responses, while in pathogenic fungi, they are important for initiating infections that can impact humans.
- * The review highlights recent research on the sphingolipid pathways in plant pathogenic fungi, noting both their unique and shared features with other organisms, and discusses the development of inhibitors to control fungal infections in crops.
Article Synopsis
- - The study focused on the frequency and risk factors of postoperative delirium in elderly patients after hip surgery, aiming to identify ways to prevent this condition.
- - Out of 97 patients analyzed, 32 (32.9%) experienced delirium post-surgery, with contributing factors including age, height, gender, and preoperative health indicators.
- - A significant finding was that the risk of delirium increased by 12% for every additional 10 years in patient age, and a history of delirium in the recovery unit was a strong predictor of developing postoperative delirium.
Article Synopsis
- * The study identifies Trs85, a crucial protein in the fungus, that regulates infection by influencing autophagy via the Ypt1 protein, highlighting its potential as a new target for fungicide development.
- * A promising compound, SP-141, has been discovered to inhibit the Trs85-Ypt1 interaction and effectively reduce fungal infection, offering a new avenue for controlling rice blast and addressing fungicide resistance.
Genetic and Neuroimaging Analysis of SIGMAR1 for Frontotemporal Dementia.
J Alzheimers Dis
September 2023
Article Synopsis
- - The study investigates the role of SIGMAR1 gene variants in frontotemporal dementia (FTD) independently of the C9orf72 pathogenic repeat expansions, which have been linked to some FTD cases.
- - Researchers sequenced the SIGMAR1 gene in 82 sporadic FTD patients and 417 controls, finding a rare variant in a male patient with semantic dementia and notable brain imaging results.
- - The findings suggest that the identified SIGMAR1 variant may influence disease progression by affecting RNA splicing, potentially contributing to the semantics-related symptoms of dementia.