Prognostic performance of examined lymph nodes, lymph node ratio, and positive lymph nodes in gastric cancer: a competing risk model study.

Background: Previous research on the prognostic effectiveness of examined lymph nodes (ELN), lymph node ratio (LNR), and positive lymph nodes (pN) in postoperative gastric cancer (GC) has yielded inconsistent results despite their widespread use.

Methods: This study used a competing risk model (CRM) to evaluate the prognostic efficacy of these markers in patients with GC. Data from 337 patients with lymph node (LN)-positive stage II GC undergoing resection and chemotherapy between 2010 and 2015 were collected from the Surveillance, Epidemiology, and End Results database.

Construction of MoS/g-CN S-scheme heterojunction promotes plasma-photocatalytic degradation of methyl p-hydroxybenzoate: Electron transfer and adsorption reduction mechanisms.

A novel method of S-scheme heterojunction photocatalyst assisted with plasma was proposed to degrade the methyl p-hydroxybenzoate (MeP) in wastewater. The two-dimensional MoS/g-CN composite was prepared by the thermal polycondensation method. The sheet-like morphologies and S-scheme heterogeneous structure were validated by XRD, XPS, EDS, FTIR, and TEM in the MoS/g-CN composite.

Butter and Plant-Based Oils Intake and Mortality.

Importance: The relationship between butter and plant-based oil intakes and mortality remains unclear, with conflicting results from previous studies. Long-term dietary assessments are needed to clarify these associations.

Objective: To investigate associations of butter and plant-based oil intakes with risk of total and cause-specific mortality among US adults.

MRI radiomics based on machine learning in high-grade gliomas as a promising tool for prediction of CD44 expression and overall survival.

We aimed to predict CD44 expression and assess its prognostic significance in patients with high-grade gliomas (HGG) using non-invasive radiomics models based on machine learning. Enhanced magnetic resonance imaging, along with the corresponding gene expression and clinicopathological data, was downloaded from online database. Kaplan-Meier survival curves, univariate and multivariate COX analyses, and time-dependent receiver operating characteristic were used to assess the prognostic value of CD44.

Unsupervised Domain Adaptation With Synchronized Self-Training for Cross-Domain Motor Imagery Recognition.

Robust decoding performance is essential for the practical deployment of brain-computer interface (BCI) systems. Existing EEG decoding models often rely on large amounts of annotated data collected through specific experimental setups, which fail to address the heterogeneity of data distributions across different domains. This limitation hinders BCI systems from effectively managing the complexity and variability of real-world data.

Impact of Herpesvirus Detection via Metagenomic Next-Generation Sequencing in Patients with Lower Respiratory Tract Infections.

Purpose: This study aimed to investigate the impact of herpesvirus detection by metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) on lower respiratory tract infections (LRTIs) patients' lung microbiome composition and prognosis.

Patients And Methods: We initially enrolled 234 hospitalized patients with LRTIs who underwent BALF mNGS between February 2022 and May 2023. The study analyzed the clinical manifestations and the pulmonary microbial composition between herpesvirus detection (HD) and non-herpesvirus detection (non-HD) group.

Long-Term Intake of Red Meat in Relation to Dementia Risk and Cognitive Function in US Adults.

Background And Objectives: Previous studies have shown inconsistent associations between red meat intake and cognitive health. Our objective was to examine the association between red meat intake and multiple cognitive outcomes.

Methods: In this prospective cohort study, we included participants free of dementia at baseline from 2 nationwide cohort studies in the United States: the Nurses' Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS).

Chemokine CXCL12 Activates CXC Receptor 4 Metastasis Signaling Through the Upregulation of a CXCL12/CXCR4/MDMX (MDM4) Axis.

Background: The metastasis-promoting G-protein-coupled receptor CXC Receptor 4 (CXCR4) is activated by the chemokine CXCL12, also known as stromal cell-derived factor 1 (SDF-1). The CXCL12/CXCR4 pathway in cancer promotes metastasis but the molecular details of how this pathway cross-talks with oncogenes are understudied. An oncogene pathway known to promote breast cancer metastasis in MDA-MB-231 xenografts is that of Mouse Double Minute 2 and 4 (MDM2 and MDM4, also known as MDMX).

The effect of esketamine combined with sufentanil based patient-controlled intravenous analgesia for postoperative pain in patients undergoing third molar surgery and maxillofacial trauma: a randomized clinical trial.

Purpose: This study aims to investigate the effects of combining esketamine with sufentanil for postoperative patient-controlled intravenous analgesia (PCIA) in patients undergoing elective impacted tooth surgery or open reduction and internal fixation.

Methods: In this single-center, prospective, double-blinded, randomized, parallel-controlled trial, 91 patients were randomly divided into two groups. The experimental group (group ES, n = 46) received a combination of sufentanil 1.

Global adherence to a healthy and sustainable diet and potential reduction in premature death.

The Planetary Health Diet (PHD), also known as the EAT-Lancet reference diet, was developed to optimize global dietary quality while keeping the environmental impacts of food production within sustainable planetary boundaries. We calculated current national and global adherence to the PHD using the Planetary Health Dietary Index (PHDI). In addition, we used data on diet and mortality from three large US cohorts (n = 206,404 men and women, 54,536 deaths) to estimate the total and cause-specific mortality among adults 20 y of age and older that could be prevented by shifting from current diets to the reference PHD.

Job Stress Can Lead to Intestinal Inflammation and Subsequent Gut-Originated Extraoral Halitosis.

Objectives: Reports on stress-associated halitosis are scarce and have only focused on intraoral halitosis. This work aimed to study stress-associated extraoral halitosis (EOH) and further investigate its potential association with stress-induced intestinal inflammation.

Methods: This retrospective study included 664 white-collar employees with self-reported stress-associated halitosis.

Advancements in nano-immunotherapy for gynecological cancers: A new frontier.

Gynecological cancers rank among the leading causes of death for women worldwide. Traditional treatment methods, including surgery, chemotherapy, and radiotherapy, are commonly employed in patients with these tumors. However, the effectiveness of these approaches remains suboptimal due to issues like treatment resistance and challenges in early detection.

A mathematical multiple-dimensional strategy for Q-markers identification based on "five principles": Tianshu Capsule for migraine treatment as an example.

Ethnopharmacological Relevance: Quality control is a critical element for Traditional Chinese medicine (TCM). Due to the varied chemical components, mechanisms of action, and pharmacological functions in TCM, ensuring quality is more challenging compared to chemical drugs. Then, the concept of quality markers (Q-markers) was proposed and ideal Q-markers for TCM prescriptions need to compliant with "five principles", including pharmacological effectiveness, specificity, transfer and traceability, measurability, and prescription compatibility.

(NHC)Ni(II)-catalyzed regioselective hydroalkenylation of norbornene derivatives: fine-tuning of NHC ligands and donor alkenes.

This study introduced a novel cross-hydroalkenylation approach for addressing a resilient challenge in C5--selective norbornene derivative functionalization. The process, guided by mutual interactions among the NHC-Ni catalyst and the substrate pairs, ensured highly chemo- and regio-selective insertion.

Effect of water molecules on the diffusion of alkali metal ions in CuHCF cathodes.

Prussian blue analogues have shown promise as cathode materials competing with sodium ion batteries, while the presence of water molecules severely affects their performance in batteries. Based on density functional theory, the effect of water molecules on the diffusion of alkali ions is revealed by employing CuHCF (copper hexacyanoferrate) as a cathode. The diffusions of alkali ions in CuHCF with or without inserted water molecules are investigated.

Morphology and selectivity of hydrated alkali metal ions as depth of discharge in the 1T-MoS electrode with aqueous electrolytes.

Aqueous ion batteries have great commercial potential in green power and energy storage due to their green nature, safety and high ionic conductivities. Different from organic electrolytes, alkali ions (Li, Na, and K) inevitably bring water molecules into the electrodes during the charging/discharging process due to the hydration of ions with water molecules. The selectivity of alkali ions and the mechanism of how water molecules are involved in the ion extraction/insertion process in the electrodes have not been clarified.

A radiomics model to predict γδ T-cell abundance and overall survival in head and neck squamous cell carcinoma.

γδ T cells are becoming increasingly popular because of their attractive potential for antitumor immunotherapy. However, the role and assessment of γδ T cells in head and neck squamous cell carcinoma (HNSCC) are not well understood. We aimed to explore the prognostic value of γδ T cell and predict its abundance using a radiomics model.

A CANCER PERSISTENT DNA REPAIR CIRCUIT DRIVEN BY MDM2, MDM4 (MDMX), AND MUTANT P53 FOR RECRUITMENT OF MDC1 AND 53BP1 TO CHROMATIN.

The influence of the metastasis promoting proteins mutant p53 (mtp53) and MDM2 on (CPR) to promote cancer cell survival is understudied. Interactions between the DNA repair choice protein 53BP1 and wild type tumor suppressor protein p53 (wtp53) regulates cell cycle control. Cancer cells often express elevated levels of transcriptionally inactive missense mutant p53 (mtp53) that interacts with MDM2 and MDM4/MDMX (herein called MDMX).

Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment.

Poly (ADP-ribose) polymerase inhibitors (PARPi) are used for patients with BRCA1/2 mutations, but patients with other mutations may benefit from PARPi treatment. Another mutation that is present in more cancers than BRCA1/2 is mutation to the TP53 gene. In 2D breast cancer cell lines, mutant p53 (mtp53) proteins tightly associate with replicating DNA and Poly (ADP-ribose) polymerase (PARP) protein.

Intracerebral fate of organic and inorganic nanoparticles is dependent on microglial extracellular vesicle function.

Nanoparticles (NPs) represent an important advance for delivering diagnostic and therapeutic agents across the blood-brain barrier. However, NP clearance is critical for safety and therapeutic applicability. Here we report on a study of the clearance of model organic and inorganic NPs from the brain.

[Expression and clinical significance of plasma exosomal miR-34-5p and miR-142-3p in systemic sclerosis].

Objective: To detect the expression of plasma exosomal microRNA (miRNA) in systemic sclerosis (SSc), and to investigate its clinical significance.

Methods: A total of 20 patients who were initially diagnosed with SSc and did not receive medication in Department of Rheumatology and Immunology of Meizhou People' s Hospital from January 2020 to January 2022 were recruited, as well as 15 healthy individuals whose gender and age matched with those of the SSc patients. Plasma exosomes were isolated using ultracentrifugation method.