Network pharmacology and molecular docking-based investigation on traditional Chinese medicine Astragalus membranaceus in oral ulcer treatment.

To analyze the mechanism of Astragalus membranaceus (AM) in molecular level in the oral ulcer (OU) treatment with reference to network pharmacology. Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform database was used in screening the AM active components and AM action targets; GeneCards database was used to screen OU targets; the common target were screened by Venny online tool; Cytoscape software was applied to construct the target gene regulation map of AM active components; STRING database was used to construct the protein-protein interaction network and the key targets were screened as per degree value; gene ontology enrichment and KEGG pathway enrichment of interactive genes were calculated through David database. There were 17 active ingredients and 429 target spots in Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform database.

Exosomal HSP90 induced by remote ischemic preconditioning alleviates myocardial ischemia/reperfusion injury by inhibiting complement activation and inflammation.

Background/aims: The activation of the complement system and subsequent inflammatory responses are important features of myocardial ischemia/reperfusion (I/R) injury. Exosomes are nanoscale extracellular vesicles that play a significant role in remote ischemic preconditioning (RIPC) cardioprotection. The present study aimed to test whether RIPC-induced plasma exosomes (RIPC-Exo) exert protective effects on myocardial I/R injury by inhibiting complement activation and inflammation and whether exosomal heat shock protein 90 (HSP90) mediates these effects.

HSP90-Mediates Liraglutide Preconditioning-Induced Cardioprotection by Inhibiting C5a and NF-κB.

Objective: We previously showed that HSP90 is involved in postconditioning cardioprotection by inhibiting complement C5a. Here, we investigated whether HSP90-mediated C5a/NF-κB inhibition is responsible for the cardioprotection conferred by liraglutide.

Methods: Rat hearts underwent a 30 min occlusion of the anterior descending coronary artery, after which reperfusion was performed for 2 h.

Dioscorea deltoidea Leaf Extract (DDLE) Attenuates Cisplatin-Induced Ovarian Injury via Regulation of Oxidative Stress.

The present study investigated Dioscorea deltoidea leaf extract (DDLE) for treatment of cisplatin-induced ovarian injury in rat model. DDLE treatment of the cisplatin-induced ovarian injury rats suppressed Follicle-stimulating hormone (FSH) release and promoted the estrogen E2 level in serum samples. Development of follicles was increased while as damage to ovarian cortex on day 14, 28, and 42 was inhibited in cisplatin-induced ovarian injury rats on treatment with DDLE.

[Inner-heating acupuncture of lumbar degenerative lesions based on β-catenin signaling pathway].

Objective: By observing the effect of inner-heating acupuncture on the expression of Wnt1, Axin and β-catenin in the intervertebral disc of rats with lumbar degenerative disease and to explore the regulatory mechanism of inner-heating acupuncture on the apoptosis of annulus fibrosus cells in rats with lumbar degenerative disease.

Methods: Forty SD rats were randomly divided into normal group, model group, inner heating acupuncture group and acupuncture group with 10 rats in each group. Except for normal group, all rats were modeled.

[Treatment of knee osteoarthritis with six-step manipulation combined with extracorporeal shock wave].

Objective: To observe the clinical effect of six-step manipulation combined with extracorporeal shock wave in the treatment of knee osteoarthritis.

Methods: Seventy-six patients with KOA from December 2016 to June 2018 were divided into control group and treatment group, 38 in each group. The patients in the control group were treated with oral medicine combined with extracorporeal shock wave therapy, while the patients in the treatment group were treated with six-step manipulation combined with shock wave therapy.

Cytoprotective effects of paeoniflorin are associated with translocator protein 18 kDa.

Paeoniflorin (PF) is one of the important active components in peony that are known to produce the neuroprotective effects. However, the involved cytoprotective factors on brain astrocytes are remain unclear. Translocator protein 18 kDa (TSPO) and its downstream neurosteroids biosynthesis play a significant role in cytoprotection.

[Effects of protease inhibitors on the activities of midgut proteases in Callosobruchus chinensis (Linnaeus) larvae.].

To clarify the effects of protease inhibitors on the activities of midgut proteases in Callosobruchus chinensis (L.) larvae, the inhibitory effects of four kinds of protease inhibitors on the activities of midgut proteases of C. chinensis larvae were examined in vitro and in feeding conditions with indoor artificial insect inoculation.

Role of CT perfusion imaging in patients with variously differentiated gastric adenocarcinoma.

Purpose: To explore the characteristics of variously differentiated gastric cancers on computed tomography (CT) perfusion imaging, including specific perfusion parameter values, and potential clinical applications in the prognosis assessment of gastric cancer.

Materials And Methods: Fifty patients with gastric cancer confirmed by gastroscope pathology were studied prospectively using CT perfusion imaging examinations on a 64-slice spiral CT scanner. The acquired volume data were used for calculations, mapping, and analysis by using an abdominal tumor perfusion protocol (deconvolution method) in the CT perfusion software package to measure 4 parameters: blood flow (BF), blood volume (BV), mean transit time (MTT), and the permeability surface (PS) area product.

2D-1H proton magnetic resonance spectroscopic imaging study on brain metabolite alterations in patients with diabetic hypertension.

The aim of the present study was to investigate the possible metabolic alterations in the frontal cortex and parietal white matter in patients with diabetic hypertension (DHT) using proton magnetic resonance (MR) spectroscopic imaging. A total of 33 DHT patients and 30 healthy control subjects aged between 45 and 75 were included in the present study. All subjects were right‑handed.

Magnetic Resonance Spectroscopy Study of Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment With No Dementia.

Amnestic mild cognitive impairment (aMCI) and vascular cognitive impairment with no dementia (VCIND) are highly predictive of Alzheimer's disease and vascular dementia. In this study, a 2-dimensional magnetic resonance spectroscopy was performed in 25 patients with aMCI, 28 patients with VCIND, and 32 normal controls (NCs). The concentrations of N-acetyl aspartate (NAA), choline (Cho), myoinositol (MI), and creatine (Cr) were measured, and their ratios were calculated.

[Multi-spectral thermometry based on radiation measurement within a finite solid-angle].

Based on Planck's law, the surface temperature of an object can be determined by measurement of emitted radiation. The equation for monochromatic radiation thermometry within a finite solid-angle was deduced, and it was found that if the surface temperature and spectral emissivity can be solved at the same time, the specific radiation measurement conditions for multi-spectral thermometry should be generally met that the radiation measurement should be implemented within an infinitesimal solid-angle or within a finite solid-angle only for a perfect diffuser. When the directional spectral emissivity modeled by finite polynomial series is employed and proper mathematical transformation is used, a universal equation for monochromatic radiation thermometry is obtained.

[Radiation thermometry based on calibration of spectral responsivity].

Abstract True surface temperatures can be determined by measurements of radiation emitted by the object. The non-spectral parameter in the radiation measurement equation is the function of the relative position between the target and the lens, so calibration of space position is necessary for temperature measurement, when emissivity and temperature are measured simultaneously. In the present paper, the non-spectral parameter was included into the undetermined coefficients of emissivity modeled by finite series, which will not affect the solution of true surface temperature.

Quantification of choline concentration following liver cell apoptosis using 1H magnetic resonance spectroscopy.

Aim: To evaluate the feasibility of quantifying liver choline concentrations in both normal and apoptotic rabbit livers in vivo, using 1H magnetic resonance spectroscopy (1H-MRS).

Methods: 1H-MRS was performed in 18 rabbits using a 1.5T GE MR system with an eight-channel head/neck receiving coil.

Quantitative multivoxel proton MR spectroscopy study of brain metabolites in patients with amnestic mild cognitive impairment: a pilot study.

Introduction: The purpose of this study is to investigate brain metabolic changes in patients with amnestic mild cognitive impairment (aMCI) using multivoxel proton MR spectroscopy ((1)H-MVS).

Methods: Fourteen aMCI patients and fifteen healthy control subjects participated in this experiment. All MR measurements were acquired using a 1.

[Relationship between temperature range and wavelength bandwidth for multi band pyrometry].

In the present paper, based on the linearity spectral emissivity model with two parameters in the narrow investigated waveband, we extend tri-wavelength pyrometry to tri-band pyrometry through waveband measurements of radiation temperature. In tri-band pyrometry, in order to realize the non-distortion measurement, considering the effect of the dynamic range and the minimum sensibility of the sensor on the coupling relation of multi-channel signals, the restriction condition of the effective temperature measurement range is discussed. However, under the assumption of the fixed sensor parameters, the measurement bandwidth of the sensor is an important influencing factor to the effective temperature measurement range in applications of tri-band pyrometry.

[Analyses of spectral emissivity in radiation temperature measurement].

The complexity of the spectral emissivity of actual surfaces is the key point in the research and applications of radiation temperature measurement, resulting in the difficulty in the achievement of the temperature measurement. In the present paper, based on the discussions of the Taylor expansion, the non-dimension wavelength and the exponent, the authors describe the mathematical expression of the spectral emissivity of actual surfaces, and establish the general spectral emissivity function. Through the fitting of experimental data of the spectral emissivities of different metals at different temperatures, the applicability of the spectral emissivity function is verified which especially becomes the fundamental in the research of primary spectrum pyrometry.

[The temperature field partition for primary spectrum pyrometry].

In the applications of primary spectrum pyrometry to the detection of temperature, through the analysis of the coupled multi-channel signals, the authors investigated the necessary condition under which all temperatures can be measured simultaneously and effectively. For the case not satisfying the above condition, the authors put forward the concept of temperature field partition. And the process of the temperature field partition is detailedly described, and the simulation results are given.

[Optimization analysis based on wavelength bandwidth for multi-band pyrometry].

The present paper establishes the optimization criteria for achieving the optimum measurements in three-band pyrometry under the assumption of linear emissivity model and the sensor design with Gaussian distribution. By varying the FWHM of Gaussian distribution, the optimization analysis is investigated with the choice of the wavelength bandwidth in three-band pyrometry. For specific cases, the simulation results present the optimum bandwidth distribution.

[Theoretical analysis of wavelength choice in tri-wavelength method of temperature measurement].

In this paper, a non-dimensional emissivity model with universality is established. For the tri-wavelength method of temperature measurement, based on the non-dimensional emissivity, the applicable measurement condition and theoretical analysis of wavelength choice are mainly introduced. In the discussion of theoretical analysis of wavelength choice, by optimizing the analysis of measurement method and the concept of isothermal line induced by the measurement coordinates, two kinds of ideal choice rules of measurement wavelength are put forward, which will be necessary to the technology application of this tri-wavelength method.

Two new benzopyran derivatives from Mallotus apelta.

From the leaves of Mallotus apelta two new benzopyran compounds (1,2) were obtained and their structures were determined using spectroscopic methods.