miR-375 upregulates lipid metabolism and inhibits cell proliferation involved in chicken fatty liver formation and inheritance via targeting recombination signal binding protein for immunoglobulin kappa J region (RBPJ).

Poultry is susceptible to fatty liver which lead to decrease egg production and increase mortality. But the potential molecular mechanisms remain largely unclear. In the current study, in combination with transcriptome sequencing and miRNA sequencing data analysis from F1 generation of the normal liver and fatty liver tissues, the differentially expressed miR-375 and its target gene RBPJ were screened and verified.

Quantum teleportation between the narrow armchair graphene nanoribbons with zigzag ends.

We study quantum teleportation between the narrow armchair graphene nanoribbons (GNRs) with zigzag ends. Several influences including Coulomb repulsion among electrons, temperature and ribbon length on the output state and teleportation fidelity are discussed in detail. Moreover, we derive the entanglement of the output state and corresponding fidelity as a function of the input and channel entanglement.

Pancreaticojejunostomy Conducive to Biological Healing in Minimally Invasive Pancreaticoduodenectomy.

Background: Pancreaticojejunostomy, an independent risk factor for pancreatic fistula, is the cause of several postoperative complications of pancreaticoduodenectomy. As suturing in minimally invasive surgery is difficult to perform, more simplified methods are needed to guarantee a safe pancreatic anastomosis. The concept of "biological healing" proposed in recent years has changed the conventional understanding of the anastomosis, which recommends rich blood supply, low tension, and loose sutures in the reconstruction of the pancreatic outflow tract.

miR-375 Induced the Formation and Transgenerational Inheritance of Fatty Liver in Poultry by Targeting .

The liver of poultry is the primary site of lipid synthesis. The excessive production of lipids accumulates in liver tissues causing lipid metabolism disorders, which result in fatty liver disease and have a transgenerational effect of acquired phenotypes. However, its specific mechanisms have not yet been fully understood.

Dynamics of quantum entanglement in a zigzag graphene nanoribbon.

We study the dynamics of entanglement between two edge spins in a zigzag graphene nanoribbon (ZGNR) which is thermalized with a reservoir at temperature. The results show that the entanglement evolution displays oscillating behaviors in the presence of an external magnetic field. Such oscillating behaviors of entanglement strongly depend on the field frequency and relative location between two inter-edge coupled spins.

The Ras-ERK signaling pathway regulates acetylated activating transcription factor 2 via p300 in pancreatic cancer cells.

Background: Activating transcription factor 2 (ATF2) regulates the expression of downstream target genes and is phosphorylated by the Ras-extracellular-signal-regulated kinase (ERK) pathway. Acetylation of ATF2 is necessary for this type of regulation. However, the molecular mechanism by which the Ras-ERK pathway mediates the regulation of acetylated ATF2 is unknown.

The Ras-ERK1/2 signaling pathway regulates H3K9ac through PCAF to promote the development of pancreatic cancer.

Aims: The regulation of the Ras-ERK pathway is the crucial point in pancreatic carcinogenesis, and the Ras kinase is an essential regulatory upstream signal molecule of the ERK1/2 pathway. H3K9ac is a vital histone modification, but its specific role in pancreatic cancer remains unclear. This research aims to study whether the modification level of H3K9ac can regulate the characteristic phenotype of the pancreatic cancer cells by affecting the downstream expression, proliferation, migration, and other related genes.

Thermal quantum correlations in zigzag graphene nanoribbons.

Based on the effective spin-ladder model, we compute the negativity and geometric quantum discord (GQD) between two edge spins in zigzag graphene nanoribbons (ZGNRs) thermalized with a reservoir at temperature T (canonical ensemble). The results show that the entanglement only exists in antiferromagnetically coupled spin pairs, and completely vanishes between any two spins at the same ribbon edge. Intriguingly, the dominant entanglement always occurs in the nearest inter-edge coupled spin pairs, which is very robust even at room temperature.

Synergism of PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells.

Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are promising targeted therapeutics for breast and ovarian cancers bearing a germline mutation ( ), and several have already received regulatory approval in the United States. In patients with a cancer, PARPi can increase the burden of unrepaired DNA double-strand breaks by blocking PARP activity and trapping PARP1 onto damaged DNA. Resistance to PARP inhibitors can block the formation of DNA double-strand breaks through BRCA-related DNA repair pathway.

Quantum dissonance in chiral graphene nanoribbons.

Based on the effective spin-ladder model, we study the properties of quantum dissonance (Q) between two edge spins in chiral graphene nanoribbons (CGNRs) thermalized with a reservoir at temperature T, and discuss the influences of relative location between two edge spins, ribbon width, temperature, and on-site Coulomb repulsion (U) on Q. The results show that Q is widely present in Wannier edge states. For intra-edge coupled spin pairs, quantum entanglement (E) is zero, but there still exists considerable value of Q.

Healthy aging: A bibliometric analysis of the literature.

Due to dramatic growth of the aging population worldwide, there has been an urgent call for a public health strategy to manage healthy aging, with the ultimate goal being advancement of aging research. Considerable progress has been made in uncovering the mystery of aging process using multidisciplinary methods. There is a growing consensus in the field that aging traits which were originally thought to be disparate are likely to be interconnected.

[Surveillance and risk assessment system of schistosomiasis epidemic focus in Hankou marshland of Wuhan City].

Objective: To construct a monitoring and risk assessment system of schistosomiasis epidemic focus in marshland, so as to grasp the risk of schistosomiasis transmission, and to provide the technical support for targeted prevention and control measures.

Methods: The crowd and the risk source of schistosomiasis in Hankou marshland in Wuhan City were monitored to grasp the risk factors of schistosomiasis. The risk level was evaluated by the three-dimensional risk matrix and three-dimensional visualization method.

Chinese version of the clinical learning environment comparison survey: Assessment of reliability and validity.

Background: Simulation is recommended as a substitute for clinical practice among nursing students. No current guidelines exist regarding the accurate percentage of simulation hours versus clinical practice hours. Comparing simulation with clinical practice is needed so that both strategies can be optimally combined in nursing education.

Efficacy and Safety of Acupuncture for Essential Hypertension: A Meta-Analysis.

BACKGROUND The aim of this study was to assess the efficacy and safety of acupuncture therapy for patients with hypertension. MATERIAL AND METHODS We searched PubMed, Embase, the Cochrane Library, the Chinese Biomedical Literature Database, the Chinese National Knowledge Infrastructure, and the Wan-fang Data Database from inception through 29 April 2017. Randomized controlled trials investigating acupuncture therapy for hypertension were included.

[Practice of engineering management and its effect on schistosomiasis control in Hankou marshland, Wuhan City].

Objective: To investigate the snail control effect of schistosomiasis control engineering in marshland within Wuhan City.

Methods: The engineering measures including surface barrier removal, molluscicide, flatting surface, topsoil stripping, topsoil covering and ditch renovation were applied to transform Hankou marshland. Then the corresponding technical parameters of engineering measures were put forward.

Surface Energy and Surface Stability of Ag Nanocrystals at Elevated Temperatures and Their Dominance in Sublimation-Induced Shape Evolution.

The surface energy and surface stability of Ag nanocrystals (NCs) are under debate because the measurable values of the surface energy are very inconsistent, and the indices of the observed thermally stable surfaces are apparently in conflict. To clarify this issue, a transmission electron microscope is used to investigate these problems in situ with elaborately designed carbon-shell-capsulated Ag NCs. It is demonstrated that the {111} surfaces are still thermally stable at elevated temperatures, and the victory of the formation of {110} surfaces over {111} surfaces on the Ag NCs during sublimation is due to the special crystal geometry.

A novel model for identification of prognostic indicator for clinical outcome of squamous cell lung carcinoma.

Squamous cell carcinoma of the lung (SCCL) is the most common and aggressive lung tumor with poor clinical outcome. Identification and development of potential genes in prognostic process could be beneficial for clinical management. Sequencing data of 300 SCCL samples at level 3 were downloaded from The Cancer Genome Atlas (TCGA) data portal.

Quantum correlations in chiral graphene nanoribbons.

We compute the entanglement and the quantum discord (QD) between two edge spins in chiral graphene nanoribbons (CGNRs) thermalized with a reservoir at temperature T (canonical ensemble). We show that the entanglement only exists in inter-edge coupled spin pairs, and there is no entanglement between any two spins at the same ribbon edge. By contrast, almost all edge spin pairs can hold non-zero QD, which strongly depends on the ribbon width and the Coulomb repulsion among electrons.

Seven protective miRNA signatures for prognosis of cervical cancer.

Cervical cancer is the second cause of cancer death in females in their 20s and 30s, but there were limited studies about its prognosis. This study aims to identify miRNA related to prognosis and study their functions. TCGA data of patients with cervical cancer were used to build univariate Cox's model with single clinical parameter or miRNA expression level.

Spin susceptibilities in armchair graphene nanoribbons with Rashba spin-orbit coupling.

Based on linear response theory, we studied the spin susceptibilities of armchair graphene nanoribbons (AGNRs) with Rashba spin-orbit coupling (RSOC) in an oscillating magnetic field. It is shown that by tuning the field frequency, RSOC or ribbon width to satisfy the resonance condition, the spins in AGNRs will be effectively magnetized at room temperature due to the electron transitions between RSOC-induced spin-split subbands. Moreover, in this process the magnitude of spin magnetization can also be flexibly manipulated by selecting different resonant frequency or RSOC.