Pressure-induced polymerization (PIP) of aromatic molecules has emerged as an effective method for synthesizing various carbon-based materials. The selection of suitable functionalized molecular precursors is crucial for obtaining the desired structures and functions. In this work, 1,4-difluorobenzene (1,4-DFB) was selected as the building block for PIP.
View Article and Find Full Text PDFBackground: Microbubble enhanced ultrasound (MEUS) can augment tissue perfusion by angiogenesis yet the best treatment ultrasound power in the initial ischemia period is uncertain.
Purpose: Considering the mechanical index (MI) is the most commonly used parameter for regulating diagnostic ultrasound power, here, we explored the effects of MEUS mediated by different MI on perfusion and sought to characterize the angiogenesis in the early stage of ischemia.
Methods: Experiments were conducted on hind limb ischemia mouse model (HLI) and MEUS was administrated in the first week every other day following induction of HLI for four times.
Background: To prevent loss of peritoneal function caused by persistent abdominal inflammation, the guidelines recommend early extubation in patients with refractory peritoneal dialysis (PD)-associated peritonitis (rPDAP). In attempt to pinpoint high-risk patient cohorts that did not respond to treatment for refractory peritonitis, we created a model to predict the effectiveness of peritonitis treatment.
Methods: This observational cohort study included PD patients from 1 January 2011 to 31 December 2020.
China has vast proven coal reserves, encompassing a wide variety of types. However, traditional coal classification methods have limitations, often leading to inaccurate classification and inefficient utilization of coal resources. To address this issue, this paper introduces the Extreme Learning Machine (ELM) as a novel coal classification method, based on the near-infrared reflectance spectroscopy (NIRS) of coal.
View Article and Find Full Text PDFObjective: The aim of this study was to develop and validate an intestinal stenosis prediction model for postoperative newborns with neonatal necrotizing enterocolitis (NEC).
Methods: Clinical information was collected on neonates who had undergone anastomosis or enterostomy because of NEC. The least absolute shrinkage and selection operator regression was applied to identify risk factors included in the model for postoperative intestinal stenosis.
Single-photon lidar stands out as a promising technology for long-distance lidar applications, owing to its attributes of single-photon sensitivity and high repetition rate. Existing single-photon lidar systems typically rely on single-point scanning for positioning and tracking, necessitating intricate and precise scanning control. In pursuit of a more concise and efficient positioning, we incorporate the four-quadrant theory to articulate the signal formula of photon detection, and propose a novel single-photon four-quadrant positioning method.
View Article and Find Full Text PDFAluminum (Al) toxicity in acidic soils leads to a considerable reduction in crop yields. MicroRNAs play essential roles in abiotic stress responses, but little is known of their role in the response of peanut (Arachnis hypogea L.) to Al stress.
View Article and Find Full Text PDFROS/redox signaling plays an important role in the regulation of signal transduction and acclimation pathways activated by multiple abiotic stresses and leaf senescence. However, the regulatory events that produce ROS under different stimuli are far from clear. Here, we report the elucidation of the molecular mechanism of an h type thioredoxin, AhTRX h2, positively regulates Al sensitivity and leaf senescence by promoting ROS.
View Article and Find Full Text PDFLeuk Res
December 2024
Ethnopharmacological Relevance: Haizao, Sargassum, is widely used to treat goiter. Gancao, Glycyrrhizae radix et rhizome, is renowned for reducing toxicity or increasing effects in traditional Chinese medicine. As a classic herb pair, Haizao-Gancao (HG) is a commonly used and effective combined therapy for goiter.
View Article and Find Full Text PDFAluminum (Al) toxicity in acidic soils reduces root growth and can lead to a considerable reduction in peanut plants ( L.). The caseinolytic protease (Clp) system plays the key role in abiotic stress response.
View Article and Find Full Text PDFThe toxicity of aluminum (Al) in acidic soil inhibits plant development and reduces crop yields. Programmed cell death (PCD) is one of the important mechanisms in the plant response to Al toxicity. However, it is yet unknown if S-nitrosoglutathione reductase (GSNOR) provides Al-PCD.
View Article and Find Full Text PDFSenescence is a cell fate driven by different types of stress that results in exit from the cell cycle and expression of an inflammatory senescence-associated secretory phenotype (SASP). Here, we demonstrate that stable overexpression of miR-96-5p was sufficient to induce cellular senescence in the absence of genotoxic stress, inducing expression of certain markers of early senescence including SASP factors while repressing markers of deep senescence including LINE-1 and type 1 interferons. Stable miR-96-5p overexpression led to genome-wide changes in heterochromatin followed by epigenetic activation of p16, p21, and SASP expression, induction of a marker of DNA damage, and induction of a transcriptional signature similar to other senescent lung and endothelial cell types.
View Article and Find Full Text PDFBackground And Aims: For patients with obesity and metabolic syndrome, bariatric procedures such as vertical sleeve gastrectomy (VSG) have a clear benefit in ameliorating metabolic dysfunction-associated steatohepatitis (MASH). While the effects of bariatric surgeries have been mainly attributed to nutrient restriction and malabsorption, whether immuno-modulatory mechanisms are involved remains unclear.
Approach And Result: Using murine models, we report that VSG ameliorates MASH progression in a weight loss-independent manner.
Background: Encapsulation of bioactive compounds within protein-based nanoparticles has garnered considerable attention in the food and pharmaceutical industries because of its potential to enhance stability and delivery. Soy protein isolate (SPI) has emerged as a promising candidate, prompting the present study aiming to modify its properties through controlled thermal and trypsin treatments for improved encapsulation efficiency (EE) of lutein and its storage stability.
Results: The EE of lutein nanoparticles encapsulated using SPI trypsin hydrolysates (SPIT) with three varying degrees of hydrolysis (4.
Background: Chronic Myeloid Leukemia (CML) is a blood cancer that remains challenging to cure due to drug resistance and side effects from current BCR-ABL inhibitors. There is an urgent need for novel and more effective BCR-ABL targeting inhibitors and therapeutic strategies to combat this deadly disease.
Method: We disclose an "OH-implant" strategy to improve a noncovalent BCR-ABL inhibitor, PPY-A, by adding a hydroxyl group to its scaffold.
Flowering is critical to the success of plant propagation. The MYB family transcription factor () is an essential component of the core loop of the circadian clock and plays a crucial role in regulating plant flowering time. In this study, we found that photoperiod affects the expression pattern and expression level of , which is delayed flowering time under short-day conditions in Pak-choi [ (.
View Article and Find Full Text PDFLamiales, comprising over 23,755 species across 24 families, stands as a highly diverse and prolific plant group, playing a significant role in the cultivation of horticultural, ornamental, and medicinal plant varieties. Whole-genome duplication (WGD) and its subsequent post-polyploid diploidization (PPD) process represent the most drastic type of karyotype evolution, injecting significant potential for promoting the diversity of this lineage. However, polyploidization histories, as well as genome and subgenome fractionation following WGD events in Lamiales species, are still not well investigated.
View Article and Find Full Text PDFDeveloping light yet strong aluminum (Al)-based alloys has been attracting unremitting efforts due to the soaring demand for energy-efficient structural materials. However, this endeavor is impeded by the limited solubility of other lighter components in Al. Here, we propose to surmount this challenge by converting multiple brittle phases into a ductile solid solution in Al-based complex concentrated alloys (CCA) by applying high pressure and temperature.
View Article and Find Full Text PDFIntroduction: Osteoporosis, characterized by dysregulation of osteoclastic bone resorption and osteoblastic bone formation, severely threatens human health during aging. However, there is still no good therapy for osteoporosis, so this direction requires our continuous attention, and there is an urgent need for new drugs to solve this problem.
Methods: Traditional Chinese Medicine Salvia divinorum monomer pomolic acid (PA) could effectively inhibit osteoclastogenesis and ovariectomized osteoporosis.