Terahertz Wave Alleviates Comorbidity Anxiety in Pain by Reducing the Binding Capacity of Nanostructured Glutamate Molecules to GluA2.

Comorbid anxiety in chronic pain is clinically common, with a comorbidity rate of over 50%. The main treatments are based on pharmacological, interventional, and implantable approaches, which have limited efficacy and carry a risk of side effects. Here, we report a terahertz (THz, 10 Hz) wave stimulation (THS) technique, which exerts nonthermal, long-term modulatory effects on neuronal activity by reducing the binding between nano-sized glutamate molecules and GluA2, leading to the relief of pain and comorbid anxiety-like behaviors in mice.

0-Dimensional/1-dimensional S-scheme AgS/BiSI hetero-structured photocatalyst for superb Cr(VI) reduction under full spectrum irradiation.

Developing ultraviolet (UV), visible (Vis) and near-infrared (NIR) responsive photocatalysts for Cr(VI) reduction is valuable. Herein, a 0-dimensional/1-dimensional (0D/1D) S-scheme AgS/BiSI hetero-structured photocatalyst was successfully synthesized, which displays greatly enhanced Cr(VI) removal activity either under UV, Vis or NIR light irradiation. In-situ characterization technique and theoretical calculation confirm that an internal electric field (IEF), directing from AgS to BiSI, exists between the interface, which facilitates the spatial-oriented separation of photoirradiated carriers.

Service quality evaluation of county-level public hospitals in Chongqing under smart healthcare.

Background: This study explores patients' perceptions and expectations of smart healthcare services from the perspective of patient experience.The aim is to provide insights for the development of smart healthcare services in hospitals.

Methods: A cluster sampling method was used to select 10 public county-level hospitals from October to November 2021 in a municipality in southwestern China.

Evaluating the Efficacy of the Male Annihilation Technique in Managing Oriental Fruit Fly (Diptera: Tephritidae) Populations through Microscopic Assessment of Female Spermathecae.

The male annihilation technique (MAT) plays a crucial role in the pest management program of the oriental fruit fly, (Hendel) (Diptera: Tephritidae). However, a suitable method for real-time and accurate assessment of MAT's control efficiency has not been established. Laboratory investigations found that motile sperms can be observed clearly under the microscope when the spermathecae dissected from mated females were torn, and no sperms were found in the spermathecae of virgin females.

Whole-Genome Sequencing of the Entomopathogenic Fungus KMZW-1 and Its Efficacy Against .

KMZW-1 is recognized for its potential as a biocontrol agent against agricultural and forestry pests, particularly due to its compatibility with integrated pest management (IPM) strategies. This study aimed to investigate the complete genome of KMZW-1 and assess its pathogenicity against . Whole-genome sequencing revealed a genome size of 47,239,278 bp, comprising 27 contigs, with a GC content of 51.

Clinicopathological Factors and Nomogram Construction for Lymph Node Metastasis in Locally Advanced Gastric Cancer.

Background: The research on lymph node metastasis (LNM) in locally advanced gastric cancer (LAGC) infiltrating the subserous tissue and serous membrane (T3-4a) is significantly inadequate. This study aims to explore the clinicopathological factors related to LNM in stages T3 and T4a LAGC, while also developing predictive nomograms.

Methods: After systematic searching and rigorous screening, 1995 T3 and 1244 T4a LAGC cases who underwent surgery without neoadjuvant or perioperative chemotherapy were selected.

Inoculation of multi-metal-resistant Bacillus sp. to a hyperaccumulator plant Sedum alfredii for facilitating phytoextraction of heavy metals from contaminated soil.

Co-contamination of soil by multiple heavy metals is a significant global challenge. An effective strategy to address this issue involves using hyperaccumulators such as Sedum alfredii (S. alfredii).

Multi-omics Approach Reveals Influenza-A Virus Target Genes Associated Genomic, Clinical and Immunological Characteristics in Cancers.

Objective: To examine the precise function of influenza A virus target genes (IATGs) in malignancy.

Methods: Using multi-omics data from the TCGA and TCPA datasets, 33 tumor types were evaluated for IATGs. IATG expression in cancer cells was analyzed using transcriptome analysis.

Research Progress on the Preparation of Manganese Dioxide Nanomaterials and Their Electrochemical Applications.

Manganese dioxide (MnO) nanomaterials have shown excellent performance in catalytic degradation and other fields because of their low density and great specific surface area, as well as their tunable chemical characteristics. However, the methods used to synthesize MnO nanomaterials greatly affect their structures and properties. Therefore, the present work systematically illustrates common synthetic routes and their advantages and disadvantages, as well as examining research progress relating to electrochemical applications.

A robust multi-scale feature extraction framework with dual memory module for multivariate time series anomaly detection.

Although existing reconstruction-based multivariate time series anomaly detection (MTSAD) methods have shown advanced performance, most assume the training data is clean. When faced with noise or contamination in training data, they can also reconstruct the anomaly well, weakening the distinction between normal and anomaly. Some probabilistic generation-based methods have been used to address this issue because of their implicit robust structure to noise, but the training process and suppression of anomalous generalization are not stable.

Blocking HR signal aggravates atherosclerosis by promoting inflammation and foam cell formation.

Atherosclerosis (AS) is a chronic inflammatory arterial disease, in which abnormal lipid metabolism and foam cell formation play key roles. Histamine is a vital biogenic amine catalyzed by histidine decarboxylase (HDC) from L-histidine. Histamine H1 receptor (HR) antagonist is a commonly encountered anti-allergic agent in the clinic.

Selective impact of three homogenous polysaccharides with different structural characteristics from Grifola frondosa on human gut microbial composition and the structure-activity relationship.

Natural polysaccharides interact with gut microbes to enhance human well-being. Grifola frondosa is a polysaccharides-rich edible and medicinal mushroom. The prebiotic potential of G.

Research progress on insect visual electrophysiological techniques.

Insect visual electrophysiological techniques are important to study the electrical characteristics of photoreceptor cells and visual neurons in insects, including electroretinography (ERG) and microelectrode intracellular recording (MIR). ERG records the changes of voltage or electric current in the retina of insects in response to different light stimuli, which occurs outside the cell. MIR records the changes in individual photoreceptor cells or visual neurons of an insect exposed to different lights, which occurs inside the cell.

Using the i-PARIHS theoretical framework to develop evidence implementation strategies for central venous catheter maintenance: a multi-site quality improvement project.

Introduction: Evidence-based nursing practice can reduce complications associated with central venous catheters (CVCs). In this project, the Integrated Promoting Action on Research Implementation in Health Services (i-PARIHS) framework was considered an ideal theoretical instrument to identify facilitators and barriers to implementing evidence-based practice.

Methods: The project was conducted in pediatric intensive care units in six Chinese tertiary children's hospitals.

Irreversible Transmural Intestinal Necrosis in Acute Mesenteric Ischemia: Retrospective Cohort Study from a High-Volume Hospital.

Owing to the low incidence rate and nonspecific symptoms of acute mesenteric ischemia (AMI), the identification and prediction of irreversible transmural intestinal necrosis (ITIN) and extensive bowel resection (≥100 cm) (EBR) are difficult and critical. This study aimed to investigate the risk factors for ITIN and EBR in patients with AMI. The clinical data of 254 AMI patients were retrospectively analyzed.

Cellular communication among smooth muscle cells: The role of membrane potential via connexins.

Communication via action potentials among neurons has been extensively studied. However, effective communication without action potentials is ubiquitous in biological systems, yet it has received much less attention in comparison. Multi-cellular communication among smooth muscles is crucial for regulating blood flow, for example.

HNCS-1: a biocontrol bacterium against tea plant diseases.

As a biocontrol bacteria, has been the subject of extensive research for agricultural applications. Antibacterial peptides (AMPs) are the main antibacterial products of . This study isolated a strain of HNCS-1 from tea garden soil, and the strain has an antagonistic effect against five types of pathogens of tea diseases, namely sp.

Disruption of Histamine-HR signaling exacerbates cardiac microthrombosis after periodontal disease via TLR4/NFκB-p65 pathway.

Periodontal disease is a chronic inflammatory disease that is highly correlated with cardiovascular disease(CVD). Histamine has been proven to participate in the pathophysiological processes of cardiovascular disease and oral inflammation. However, the role of histamine in the development of cardiac microthrombosis caused by periodontal disease has not been fully elucidated.

Rapid cold hardening and cold acclimation promote cold tolerance of oriental fruit fly, (Hendel) by physiological substances transformation and cryoprotectants accumulation.

Insect response to cold stress is often associated with adaptive strategies and chemical variation. However, low-temperature domestication to promote the cold tolerance potential of and transformation of main internal substances are not clear. Here, we use a series of low-temperature exposure experiments, supercooling point (SCP) measurement, physiological substances and cryoprotectants detection to reveal that pre-cooling with milder low temperatures (5 and 10°C) for several hours (rapid cold hardening) and days (cold acclimation) can dramatically improve the survival rate of adults and pupae under an extremely low temperature (-6.

Degradation of sulfamethoxazole by super-hydrophilic MoS sponge co-catalytic Fenton: Enhancing Fe/Fe cycle and mass transfer.

To promote the cycle of Fe/Fe in co-catalytic Fenton and enhance mass transfer in an external circulation sequencing batch packed bed reactor (ECSPBR), super-hydrophilicity MoS sponge (TMS) modified by tungstosilicic acid (TA) was prepared for efficiently degrading sulfamethoxazole (SMX) antibiotics in aqueous solution. The influence of hydrophilicity of co-catalyst on co-catalytic Fenton and the advantages of ECSPBR were systematically studied through comparative research methods. The results showed that the super hydrophilicity increased the contact between Fe and Fe with TMS, then accelerated Fe/Fe cycle.

Leveraging twitter data to understand nurses' emotion dynamics during the COVID-19 pandemic.

The nursing workforce is the largest discipline in healthcare and has been at the forefront of the COVID-19 pandemic response since the outbreak of COVID-19. However, the impact of COVID-19 on the nursing workforce is largely unknown as is the emotional burden experienced by nurses throughout the different waves of the pandemic. Conventional approaches often use survey question-based instruments to learn nurses' emotions, and may not reflect actual everyday emotions but the beliefs specific to survey questions.

High-efficient degradation of chloroquine phosphate by oxygen doping MoS co-catalytic Fenton reaction.

To degrade the antiviral and antimalarial drug chloroquine phosphate (CQP), an oxygen doping MoS nanoflower (O-MoS-230) co-catalyst was prepared by a hydrothermal method to construct an O-MoS-230 co-catalytic Fenton system (O-MoS-230/Fenton) without pH adjustment (initial pH 5.4). Remarkable CQP degradation efficiency (99.