Ultra-Performance Liquid Chromatography-Mass Spectrometry-Based Untargeted Metabolomics Reveals the Key Potential Biomarkers for Castor Meal-Induced Enteritis in Juvenile Hybrid Grouper (♀ × . ♂).

The intensification of aquaculture to help kerb global food security issues has led to the quest for more economical new protein-rich ingredients for the feed-based aquaculture since fishmeal (FM, the ingredient with the finest protein and lipid profile) is losing its acceptability due to high cost and demand. Although very high in protein, castor meal (CM), a by-product after oil-extraction, is disposed-off due to the high presence of toxins. Concurrently, the agro-industrial wastes' consistent production and disposal are of utmost concern; however, having better nutritional profiles of these wastes can lead to their adoption.

Influence of different oil sources on growth, disease resistance, immune response and immune-related gene expression on the hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatu), to Vibrio parahaemolyticus challenge.

The aim of this study was to investigate the effects of feeding alternative dietary oils to hybrid grouper fish (♀Epinephelus fuscoguttatus × ♂E. lanceolatu) on their growth, histological morphology of hepatocytes, disease resistance, immune response, and expression of immune-related genes. Seven experimental fish meal-based isonitrogenous and isolipidic diets were formulated containing 5% fish oil (FO; acting as controls) and various vegetable oils (VOs): corn oil (CO), sunflower oil (SO), tea oil (TO), olive oil (OO), rice oil (RO), and mixed oil (MO); comprising equal amounts of these oils).

Entanglement optimization of filtered output fields in cavity optomechanics.

Output entanglement is a key element in quantum information processing. Here, we show how to obtain optimal entanglement between two filtered output fields in a three-mode optomechanical system. First, we obtain the key analytical expression of optimal time delay between the two filtered output fields, from which we can obtain the optimal coupling for output entanglement without time delay.

Recurrence of Giant Cell Tumor of the Spine after Resection: A Report of 10 Cases.

Objective: To review the clinical details and further treatments for recurrent spinal giant cell tumors (SGCT), and to analyze the risk factors of recurrence and shed new light on the treatment options and prognosis of recurrent SGCT.

Methods: A retrospective analysis of recurrent SGCT between April 2003 and January 2014 was performed. A total of 10 patients comprising 3 men and 7 women with a mean age of 28.

Prevalence and Related Factors for Myopia in School-Aged Children in Qingdao.

Purpose: To investigate the prevalence and related factors for myopia in school-aged children in the Economic and Technological Development Zone of Qingdao, Eastern China.

Methods: A total of 4890 (aged 10 to 15 years) students were initially enrolled in this study. 3753 (76.

Open Surgery for Osteoid Osteoma with Three Dimensional C-arm Scan under the Guidance of Computer Navigation.

Objective: To evaluate the clinical outcomes of open surgery for osteoid osteoma with three-dimensional (3-D) C-arm scan under the guidance of computer navigation.

Methods: The clinical data of 14 patients who had undergone 3-D C-arm scan under the guidance of computer navigation during open surgery for osteoid osteoma from March 2012 to June 2015 were analyzed retrospectively. There were nine male and five female subjects aged from 9 to 55 years (mean, 26 years).

Clinical and Radiographic Results of Reconstruction with Fibular Autograft for Distal Radius Giant Cell Tumor.

Objective: To evaluate the result of en bloc resection and reconstruction of the distal radius with a non-vascularized fibular autograft for giant cell tumor (GCT) of bone.

Methods: Between 2005 and 2015, 12 eligible patients (seven males, five females, mean age 31.3 years) with grade III GCT of the distal radius were treated by en bloc resection and reconstruction with non-vascularized proximal fibular autografts in four Chinese institutions (members of Giant Cell Tumor Team of China).

[Factors related to therapeutic outcomes of intravenous thrombolysis in stroke patients with different severity].

Objective: To investigate the factors related to therapeutic outcomes of intravenous thrombolysis in patients with acute ischemic stroke (AIS) of different severity.

Methods: Clinical data of patients with AIS treated with intravenous thrombolysis in the Second Affiliated Hospital, Zhejiang University School of Medicine between June 2009 and December 2013 were retrospectively reviewed. According to National Institutes of Health Stroke Scale (NIHSS), patients were categorized as mild stroke (≤8, n=134), moderate stroke (9-15, n=121) and severe stroke(≥16, n=110).

Cancer prediction based on radical basis function neural network with particle swarm optimization.

This paper addresses cancer prediction based on radial basis function neural network optimized by particle swarm optimization. Today, cancer hazard to people is increasing, and it is often difficult to cure cancer. The occurrence of cancer can be predicted by the method of the computer so that people can take timely and effective measures to prevent the occurrence of cancer.

Coherent perfect absorption, transmission, and synthesis in a double-cavity optomechanical system.

We study a double-cavity optomechanical system in which a movable mirror with perfect reflection is inserted between two fixed mirrors with partial transmission. This optomechanical system is driven from both fixed end mirrors in a symmetric scheme by two strong coupling fields and two weak probe fields. We find that three interesting phenomena: coherent perfect absorption (CPA), coherent perfect transmission (CPT), and coherent perfect synthesis (CPS) can be attained within different parameter regimes.

Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: the role of Akt and nuclear factor-kappaB.

Genistein, a nontoxic flavonoid compound, has potent antitumor activity in various cancer cell lines. This study was designed to investigate whether combination therapy with gemcitabine and genistein enhances antitumor efficacy in osteosarcoma cell lines (MG-63 and U2OS). Our results show that significant reduction in cell viability and corresponding induction of apoptosis were observed with combination treatment in both cell lines.

Caspase-8 dependent osteosarcoma cell apoptosis induced by proteasome inhibitor MG132.

Many researchers have reported that proteasome inhibitors could induce apoptosis in a variety of cancer cells, such as breast cancer cell, lung cancer cell, and lymphoma cell. However, the effect of proteasome inhibitors on osteocsarcoma cells and the mechanisms are seldom studied. In this study, we found proteasome inhibitor MG132 was an effective inducer of apoptosis in human osteosarcoma MG-63 cells.