Single gold nanowire-nanoparticles conjugated system: Fabrication and sensing application.

Single-entity-based sensing platform has many advantages for real-time assays, such as single-molecule analysis, or targets detection in confined environment. In this contribution, a new single Au nanowire (NW) - Au@Pt/Au nanoparticles (Au@Pt/Au NPs) conjugated system was established and used for the detection of thrombin by using surface-enhanced Raman spectroscopy (SERS) technique. This method was mainly based on electrostatic attraction between the capture (thrombin aptamer) and probe molecules (crystal violet, CV) on the surface of Au NW - Au@Pt/Au NPs conjugation, reducing the adsorption of CV molecules on conjugation surface, and resulting the decrease of SERS signals.

SERS and electrochemical dual-mode detection of miRNA-141 by using single Au@Ag nanowire as a new platform.

As biomarkers of cancer, the accurate and sensitive detection of microRNAs is of great significance. Therefore, we proposed a surface-enhanced Raman scattering (SERS)/electrochemical (EC) dual-mode nanosensor for sensitively detecting miRNA-141. The nanosensor uses Au@Ag nanowires as a novel SERS/EC sensing platform, which has the advantages of good biocompatibility, fast response, and high sensitivity.

New nanosensor fabricated on single nanopore electrode filled with prussian blue and graphene quantum dots coated by polypyrrole for hydrogen peroxide sensing.

Hydrogen peroxide (HO) is a common oxidant that plays an important role in many biological processes and is also an important medium analysis in various fields. In this work, a new electrochemical nanosensor capable of detecting and quantifying hydrogen peroxide was introduced. This nanosensor was fabricated by electrodepositing prussian blue (PB)/graphene quantum dots (GQDs)/polypyrrole (PPy) on single nanopore electrode etched from single gold nanoelectrode.